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Upstream

RELATED TOPICS

 * Bioreactors
 * Biochemicals/Raw Materials
 * Cell Culture Media

 * Expression Platforms
 * Microbial Cell Culture
 * Perfusion Cell Culture

RECENT IN UPSTREAM

See all
BPI Theater panelists
Expression Platforms
Improving Expression and Manufacturing of Novel BiologicsImproving Expression
and Manufacturing of Novel Biologics
byBrian Gazaille
Jul 31, 2024
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Bioreactors
BPI Theater Interview: Nick Jackowetz, Senior Vice President and Principal
Scientist, Hydrosome LabsBPI Theater Interview: Nick Jackowetz, Senior Vice
President and Principal Scientist, Hydrosome Labs
byBPI Editors
Jul 31, 2024
Downstream

RELATED TOPICS

 * Chromatography
 * Filtration

 * Separation/Purification
 * Viral Clearance

RECENT IN DOWNSTREAM

See all
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Chromatography
LC-MS Detection of Host Cell Proteins: Antibody Affinity Extraction Sample
Preparation Outperforms Native DigestionLC-MS Detection of Host Cell Proteins:
Antibody Affinity Extraction Sample Preparation Outperforms Native Digestion
byAlla Zilberman, Darren Bertinand 4 more
Jul 29, 2024
Manufacturing

RELATED TOPICS

 * Biosimilars
 * Continuous Bioprocessing
 * Facility Design/Engineering
 * Formulation
 * Single Use
 * Fill/Finish

 * Information Technology
 * Process Monitoring and Controls
 * Supply Chain
 * Validation
 * CMC Forums

RECENT IN MANUFACTURING

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Bioprocess Insider
NIIMBL seeks industry guidance to enhance biomanufacturing processesNIIMBL seeks
industry guidance to enhance biomanufacturing processes
byJosh Abbott
Aug 16, 2024
2 Min Read
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Bioprocess Insider
Amgen expands global footprint with tech center in IndiaAmgen expands global
footprint with tech center in India
byShreeyashi Ojha
Aug 14, 2024
1 Min Read
Analytical

RELATED TOPICS

 * QA/QC
 * Cell Line Development
 * PAT
 * Product Characterization

 * Bioanalytical Methods
 * Process Development
 * Assays
 * Laboratory Equipment

RECENT IN ANALYTICAL

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QA/QC
[Test] video padding[Test] video padding
Aug 13, 2024
BPI Theater Panelists
Process Development
Driving Therapies Forward with the End Goal in MindDriving Therapies Forward
with the End Goal in Mind
byCheryl Scott
Jul 31, 2024
Business

RELATED TOPICS

 * Bioregions
 * Careers & Training
 * Contract Services
 * Economics

 * Pre-Clinical & Clinical Trials
 * Risk Management
 * Intellectual Property
 * Regulatory Affairs

RECENT IN BUSINESS

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Bioprocess Insider
Key strategies for effective technology evaluationKey strategies for effective
technology evaluation
byKim Bennett
Aug 8, 2024
2 Min Read
BPI Theater presenter
Risk Management
What Unseen Trouble Lies Within Your Processes?What Unseen Trouble Lies Within
Your Processes?
byBPI Editors
Jul 31, 2024
Therapeutic Modalities

RELATED TOPICS

 * Cell Therapies
 * Emerging Therapeutics
 * Gene Therapies
 * Large Molecule Development

 * MAb
 * Personalized Medicine
 * Vaccines

RECENT IN THERAPEUTIC MODALITIES

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BPI Theater presenter
Gene Therapies
Seamless Viral-Vector Technology Transfer at Any Phase: Offering Stability in
Times of ChangeSeamless Viral-Vector Technology Transfer at Any Phase: Offering
Stability in Times of Change
byBPI Editors
Jul 31, 2024
BPI Theater Panelists
Cell Therapies
The Make-or-Buy Decision for Cell and Gene Therapy Manufacturing: Implications
for Overcoming Manufacturing Bottlenecks and ChallengesThe Make-or-Buy Decision
for Cell and Gene Therapy Manufacturing: Implications for Overcoming
Manufacturing Bottlenecks and Challenges
byCheryl Scott
Jul 31, 2024
BioProcess Insider

RELATED TOPICS

 * Deal-Making
 * Facilities & Capacity
 * Global Markets
 * Regulations

 * Therapeutic Class
 * Upstream & Downstream Processing
 * Webcasts
 * BioProcess Insider Podcasts

RECENT IN BIOPROCESS INSIDER

See all
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Bioprocess Insider
NIIMBL seeks industry guidance to enhance biomanufacturing processesNIIMBL seeks
industry guidance to enhance biomanufacturing processes
byJosh Abbott
Aug 16, 2024
2 Min Read
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Bioprocess Insider
Reuters reports Repligen offer to buy Maravai LifeSciencesReuters reports
Repligen offer to buy Maravai LifeSciences
byJosh Abbott
Aug 16, 2024
1 Min Read




INSIDER NEWS


CDMO LONZA SECURES £30M SUBSIDY FOR UK BIOLOGICS SITE

Aug 16, 2024


VIR ACQUIRES SANOFI'S $100M PLATFORM, BOLSTERS CANCER PIPELINE

Aug 12, 2024


ANDELYN LICENSES BROAD INSTITUTE PLASMIDS TO BOLSTER GENE-THERAPY RESEARCH

Aug 9, 2024


RZNOMICS, SK PHARMTECO SIGN MOU TO BOLSTER GENE THERAPY DEVELOPMENT

Aug 8, 2024
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Bioregions


US–INDIA COLLABORATIVE INNOVATIONS FOR RAPID DRUG DISCOVERY


US–INDIA COLLABORATIVE INNOVATIONS FOR RAPID DRUG DISCOVERY

Jun 12, 2024
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Information Technology
Keys to Successful Technology Transfer
Keys to Successful Technology Transfer

Jun 12, 2024

stacked hands on virtual globe
Information Technology
Transforming Biopharmaceutical Research Embracing the Potential of Digital
Collaboration Platforms
Transforming Biopharmaceutical Research Embracing the Potential of Digital
Collaboration Platforms

Jun 12, 2024




LATEST ISSUE

April 2024 Issue

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Antibody Technologies

Engineering and Therapeutics



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Special Report

Enhancing Cell Viability Through Controlled Freezing



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INSIDER DAILY: BIOPROCESS INTERNATIONAL EUROPE

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Upstream Processing

Sponsored Content
Empowering Biologic Breakthroughs: Transforming Tomorrow’s Healthcare Landscape
Through Microbial-Based Development and Manufacturing
Empowering Biologic Breakthroughs: Transforming Tomorrow’s Healthcare Landscape
Through Microbial-Based Development and Manufacturing
Cell Culture Media
Development of Advanced Feed Media and Supplements (Webcast Recap)
Development of Advanced Feed Media and Supplements (Webcast Recap)

Bioreactor
Bioreactors
Lessons in Bioreactor Scale-Up: Part 1 — Exploring Introductory Principles
Lessons in Bioreactor Scale-Up: Part 1 — Exploring Introductory Principles

View More

Downstream Processing

Separation/Purification
Fc-Fusion Protein Capture Purification: Comparing an Innovative Membrane
Adsorber Against Standard Column and Resin Materials
Fc-Fusion Protein Capture Purification: Comparing an Innovative Membrane
Adsorber Against Standard Column and Resin Materials
Separation/Purification
Shear Assessment for Cell-Culture Clarification in a Disc-Stack Centrifuge
Shear Assessment for Cell-Culture Clarification in a Disc-Stack Centrifuge

Separation/Purification
Microorganism Contamination in Downstream Biopharmaceutical Processes: A
Holistic Approach to Measurement, Control, and Prevention
Microorganism Contamination in Downstream Biopharmaceutical Processes: A
Holistic Approach to Measurement, Control, and Prevention

View More

Manufacturing

Monoclonal Antibody Productivity
Single Use
A Fully Single-Use Downstream Process for Monoclonal Antibodies
A Fully Single-Use Downstream Process for Monoclonal Antibodies
Artificial intelligence
Information Technology
Using Artificial Intelligence for Monoclonal Antibody Discovery
Using Artificial Intelligence for Monoclonal Antibody Discovery

hydrogels as cell encapsulants
Cell Therapies
Characterization of Hydrogel Carriers: Improving the Efficacy of Existing Cell
Therapies
Characterization of Hydrogel Carriers: Improving the Efficacy of Existing Cell
Therapies

View More


Analytical

Cell Therapies
Analytical Considerations for Gene-Modified Hematopoietic Stem and Progenitor
Cell Therapies: Part 1 — In-Process and Drug Product Control
Analytical Considerations for Gene-Modified Hematopoietic Stem and Progenitor
Cell Therapies: Part 1 — In-Process and Drug Product Control
QA/QC
Practical Applications of Process Capability Indices in the Biopharmaceutical
Industry: A Simulation-Based Study
Practical Applications of Process Capability Indices in the Biopharmaceutical
Industry: A Simulation-Based Study

Corrective and preventive actions
QA/QC
Determining Sample Size for Demonstrating Zero Failures: Ensuring the
Effectiveness of Corrective and Preventive Actions
Determining Sample Size for Demonstrating Zero Failures: Ensuring the
Effectiveness of Corrective and Preventive Actions

View More

Business

scientist at computer
Bioregions
US–India Collaborative Innovations for Rapid Drug Discovery
US–India Collaborative Innovations for Rapid Drug Discovery
Outsourcing — India's Burgeoning Biologics CDMO Marketplace eBook Cover
Sponsored Content
eBook: Outsourcing — India's Burgeoning Biologics CDMO Marketplace
eBook: Outsourcing — India's Burgeoning Biologics CDMO Marketplace

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Economics
Navigating Choppy Waters: Three Resilient Marketing Tactics for Biotechnology
Companies amid Market Turmoil
Navigating Choppy Waters: Three Resilient Marketing Tactics for Biotechnology
Companies amid Market Turmoil

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Therapeutic Modalities

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Cell Therapies
Elevating the CGT Manufacturing Game: How Outsourcing Enables Success
Elevating the CGT Manufacturing Game: How Outsourcing Enables Success
Allogeneic Cell Therapy eBook cover
Sponsored Content
eBook: Allogeneic Cell Therapy — From Clinical Concept to Viable Product
eBook: Allogeneic Cell Therapy — From Clinical Concept to Viable Product

Macroscopic macrophage image
Emerging Therapeutics
A Milestone in Macrophage-Based Cancer Treatment: Leveraging Chimeric Antigen
Receptors To Address Solid Tumors
A Milestone in Macrophage-Based Cancer Treatment: Leveraging Chimeric Antigen
Receptors To Address Solid Tumors

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LATEST EBOOKS

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Fill/FinisheBook: Drug Delivery — New Formats for Novel BiopharmaceuticalseBook:
Drug Delivery — New Formats for Novel Biopharmaceuticals



Cell TherapieseBook: Allogeneic Cell Therapy — From Clinical Concept to Viable
ProducteBook: Allogeneic Cell Therapy — From Clinical Concept to Viable Product



Sponsored ContenteBook: Process Intensification — Driving Efficiencies Across
the Spectrum of BiomanufacturingeBook: Process Intensification — Driving
Efficiencies Across the Spectrum of Biomanufacturing






Special Reports


Sponsored Content
Empowering Biologic Breakthroughs: Transforming Tomorrow’s Healthcare Landscape
Through Microbial-Based Development and ManufacturingEmpowering Biologic
Breakthroughs: Transforming Tomorrow’s Healthcare Landscape Through
Microbial-Based Development and Manufacturing

Microbial expression systems are crucial in developing innovative medicines and
expanding development pipelines due to the broad range of molecule formats that
can be obtained using this technology. However, this approach can be challenging
as it requires a variety of manufacturing processes to handle these diverse
molecule formats. This is where collaboration with an experienced organization
comes into play. Boehringer Ingelheim, known for its proficiency in this
technical domain, has a proven track record with 19 commercial microbial
products and successful audits and regulatory compliance. The company's
commitment to quality and flexibility in implementing production processes make
it a reliable partner. Its technology-platform neutrality also simplifies
technology and process transfers. Fill out the form below to read the full
report.

Sponsored Content
Vaccine Downstream Production: Purification Tools for Various ModalitiesVaccine
Downstream Production: Purification Tools for Various Modalities

As vaccine modalities abound, this special report provides a consolidated
overview of a variety of chromatographic purification tools for various vaccine
modalities, such as virus-like particles (VLPs), viral vectors, recombinant
protein subunits, and mRNA-based vaccines. This includes a successful
protein-based malaria vaccine production process highlighting the use of the
C-tag affinity tag system as a versatile tool for the detection and purification
of therapeutic recombinant proteins. Next, it explores the scalable purification
of mRNA-based vaccines, such as those deployed against COVID-19, with the
application of POROS(TM) Oligo(dT)25 affinity resin. Further, cation exchange
chromatography tools are highlighted by the purification of VLPs against human
papillomavirus (HPV) using POROS(TM) HS50 resin. Additionally, the baculovirus
expression vector system (BEVS) for insect-cell expression of recombinant
proteins is presented, with a focus on VLP manufacturing and purification tools,
showcasing the c...

See all

Ask the Expert Webcasts


Sponsored Content
Highly Efficient Perfusion Processes Using XCell® ATF 2 and ATF 6 Single-Use
Devices for 50 DaysHighly Efficient Perfusion Processes Using XCell® ATF 2 and
ATF 6 Single-Use Devices for 50 Days

This webcast features: Jan Ott , Research Associate, ZHAW Life Sciences and
Facility Management. The current focus in industry and research is on the
process intensification of biopharmaceutical production processes. In the
upstream process, one promising approach is to switch from fed-batch to
perfusion mode, which promises higher productivity. In this collaboration
project, an XCell® ATF 6 Single-Use Device operated with the XCell® LS
Controller was combined with the Thermo Scientific 50 L HyPerforma™ DynaDrive™
Single-Use Bioreactor. To demonstrate the scalability, the process was also
carried out in a 2 L glass bioreactor with an XCell® ATF 2 Single-Use Device.
Both cultivations were fully automated regarding bleed, harvest, and glucose
control. In summary, the results presented show how highly productive production
processes are possible with modern cell retention methods and innovative
bioreactors. The scale transfer from laboratory to pilot scale was carried out
successfully and comparable results...

Sponsored Content
Real-Time Monitoring of AAV CQAs in a Chromatographic Polishing StepReal-Time
Monitoring of AAV CQAs in a Chromatographic Polishing Step

This webcast features: F. Michael Haller, PhD, Principal Scientist , Lonza
Biologics & Dan Some, PhD, Senior Principal Scientist , Waters | Wyatt
Technology. Downstream purification and enrichment of full capsids for AAV-based
gene therapy products, along with aggregate removal, is typically accomplished
by ion-exchange chromatography (IEX). Development of this process usually
requires sending multiple fractions for offline analysis for each iteration of
process conditions, creating a bottleneck that holds back time-to-market and
burdens both the development and analytical teams. Real-time multi-angle light
scattering (RT-MALS) is a process analytical technique that quantifies
biophysical attributes of AAVs including Vg/Cp, titer and aggregation. RT-MALS
provides immediate, high-density feedback on critical quality attributes (CQAs)
during the chromatography run, eliminating burdensome offline analyses, and
enables optimized control over the collection of purified product. This webcast
will present RT-...

See all

White Papers

Valgenesis transforming pharmaceutical development
Sponsored Content
Transforming Pharmaceutical Development: Combining Digital Platforms and QbD
Principles
Transforming Pharmaceutical Development: Combining Digital Platforms and QbD
Principles


Thermo Fisher Scientific TrypLE
Sponsored Content
Gibco TrypLE Select Enzyme: An Alternative to Animal Trypsin for Cell
Dissociation
Gibco TrypLE Select Enzyme: An Alternative to Animal Trypsin for Cell
Dissociation

Sponsored Content
Single-Use Upstream Processing: Ultimus® Film Delivers Comparable Cell Growth
Performance To Glass
Single-Use Upstream Processing: Ultimus® Film Delivers Comparable Cell Growth
Performance To Glass
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Posters

Accelerating Cell Line Development with an Efficient, Combined Platform Approach
Sponsored Content
Accelerating Cell Line Development with an Efficient, Combined Platform Approach
Accelerating Cell Line Development with an Efficient, Combined Platform Approach
Evaluation Of a New Glucose Control Strategy Using CITSens Bio APC (Automated
Process Control) for CHO Fed-Batch Application
Sponsored Content
Evaluation Of a New Glucose Control Strategy Using CITSens Bio APC (Automated
Process Control) for CHO Fed-Batch Application
Evaluation Of a New Glucose Control Strategy Using CITSens Bio APC (Automated
Process Control) for CHO Fed-Batch Application



High Productivity and Process Economy in GxP Applications with the Octet™
Platform
Sponsored Content
High Productivity and Process Economy in GxP Applications with the Octet™
Platform
High Productivity and Process Economy in GxP Applications with the Octet™
Platform
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Videos

Sponsored Content
Accelerating Process Development Through Rapid Aggregate Screening
Accelerating Process Development Through Rapid Aggregate Screening

View More

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