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Learn how AbbVie could help you save on SKYRIZI.
Call 1.866.SKYRIZI or click tap to learn more ▸



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 * Important Safety Information
 * Full Prescribing Information & Patient Information
    * Full Prescribing Information (English)
    * Medication Guide

 * Healthcare Professionals Site

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    * Moderate to Severe Plaque Psoriasis
    * Active Psoriatic Arthritis
    * Moderate to Severe Crohn's Disease
    * Moderate to Severe Ulcerative Colitis

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CHOOSE YOUR CONDITION


CHOOSE YOUR CONDITION

Moderate to SeverePlaque Psoriasis
ActivePsoriatic Arthritis
Moderate to SevereCrohn’s Disease
NOW APPROVED Moderate to Severe Ulcerative Colitis


DISCOVER SKYRIZI: A TREATMENT WITH PROVEN RESULTS

SKYRIZI can help deliver
symptom relief in 4 conditions.
See if it may be right for you.




ABOUT SKYRIZI

SKYRIZI is a biologic that has been prescribed to more than 200,000 patients in
the USA.*


*Includes adults with: Plaque Psoriasis, Psoriatic Arthritis, and Crohn’s
disease. Data is sourced from Symphony Health (PatientSource®) and SKYRIZI
Bridge Program data from April 2019 through September 2023.


YOU COULD GET SKYRIZI FOR AS LITTLE AS $0† PER DOSE

With the Skyrizi Complete Savings Card, you may pay as little as $0 per dose if
you are an eligible, commercially insured patient. More than just savings,
Skyrizi Complete offers resources, including the Skyrizi Complete App, to help
you start and stay on track with your prescribed treatment plan. You’ll also get
dedicated 1-to-1 support to help you navigate your insurance or get answers to
questions about your condition.

Discover Ways to Save and More

†For eligible, commercially insured patients only.
Please see Terms and Conditions. $0 per dose for SKYRIZI.



With the Skyrizi Complete Savings Card, you may pay as little as $0 per dose if
you are an eligible, commercially insured patient. More than just savings,
Skyrizi Complete offers resources, including the Skyrizi Complete App, to help
you start and stay on track with your prescribed treatment. You’ll also get
dedicated 1-to-1 support to help you navigate your insurance or get answers to
questions about your condition.

Discover Ways to Save and More

*For eligible, commercially insured patients only.
Please see Terms and Conditions. $0 per dose for SKYRIZI.



Looking for more information on SKYRIZI?

Get the information you need delivered straight to your inbox.

Sign Up for SKYRIZI Info

Already on SKYRIZI?

Make the most of resources available to you through Skyrizi Complete, including
savings support.

Log In or Sign Up for Skyrizi Complete


USES

SKYRIZI is a prescription medicine used to treat adults with:

 * moderate to severe plaque psoriasis who may benefit from taking injections or
   pills (systemic therapy) or treatment using ultraviolet or UV light
   (phototherapy).
 * active psoriatic arthritis.
 * moderate to severe Crohn's disease.
 * moderate to severe ulcerative colitis.


IMPORTANT SAFETY INFORMATION

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT SKYRIZI®
(RISANKIZUMAB-RZAA)?

SKYRIZI IS A PRESCRIPTION MEDICINE THAT MAY CAUSE SERIOUS SIDE EFFECTS,
INCLUDING:

SERIOUS ALLERGIC REACTIONS:

 * Stop using SKYRIZI and get emergency medical help right away if you get any
   of the following symptoms of a serious allergic reaction:
   * - fainting, dizziness, feeling lightheaded
     (low blood pressure)
   * - swelling of your face, eyelids, lips, mouth,
     tongue, or throat
   * - trouble breathing or throat tightness
   * - chest tightness
   * - skin rash, hives
   * - itching

INFECTIONS:

SKYRIZI may lower the ability of your immune system to fight infections and may
increase your risk of infections. Your healthcare provider should check you for
infections and tuberculosis (TB) before starting treatment with SKYRIZI and may
treat you for TB before you begin treatment with SKYRIZI if you have a history
of TB or have active TB. Your healthcare provider should watch you closely for
signs and symptoms of TB during and after treatment with SKYRIZI.

 * Tell your healthcare provider right away if you have an infection or have
   symptoms of an infection, including:
   * - fever, sweats, or chills
   * - cough
   * - shortness of breath
   * - blood in your mucus (phlegm)
   * - muscle aches
   * - warm, red, or painful skin
     or sores on your body different from your psoriasis
   * - weight loss
   * - diarrhea or stomach pain
   * - burning when you urinate or urinating more often than normal

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the
ingredients in SKYRIZI. See the Medication Guide or Consumer Brief Summary for a
complete list of ingredients.

BEFORE USING SKYRIZI, TELL YOUR HEALTHCARE PROVIDER ABOUT ALL OF YOUR MEDICAL
CONDITIONS, INCLUDING IF YOU:

 * have any of the conditions or symptoms listed in the section "What is the
   most important information I should know about SKYRIZI?"
 * have an infection that does not go away or that keeps coming back.
 * have TB or have been in close contact with someone with TB.
 * have recently received or are scheduled to receive an immunization (vaccine).
   Medicines that interact with the immune system may increase your risk of
   getting an infection after receiving live vaccines. You should avoid
   receiving live vaccines right before, during, or right after treatment with
   SKYRIZI. Tell your healthcare provider that you are taking SKYRIZI before
   receiving a vaccine.
 * are pregnant or plan to become pregnant. It is not known if SKYRIZI can harm
   your unborn baby.
 * are breastfeeding or plan to breastfeed. It is not known if SKYRIZI passes
   into your breast milk.
 * become pregnant while taking SKYRIZI. You are encouraged to enroll in the
   Pregnancy Registry, which is used to collect information about the health of
   you and your baby. Talk to your healthcare provider or call 1-877-302-2161 to
   enroll in this registry.

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.

WHAT ARE THE POSSIBLE SIDE EFFECTS OF SKYRIZI?

SKYRIZI may cause serious side effects. See "What is the most important
information I should know about SKYRIZI?"

Liver problems may happen while being treated for Crohn's disease or ulcerative
colitis: A person with Crohn's disease who received SKYRIZI through a vein in
the arm developed changes in liver blood tests with a rash that led to
hospitalization. Your healthcare provider will do blood tests to check your
liver before, during, and at least up to 12 weeks of treatment, and may stop
treatment with SKYRIZI if you develop liver problems. Tell your healthcare
provider right away if you notice any of the following symptoms: unexplained
rash, nausea, vomiting, stomach (abdominal) pain, tiredness (fatigue), loss of
appetite, yellowing of the skin and eyes (jaundice), and dark urine.

The most common side effects of SKYRIZI in people treated for Crohn’s disease
and ulcerative colitis include: upper respiratory infections, headache, joint
pain, stomach (abdominal) pain, injection site reactions, low red blood cells
(anemia), fever, back pain, urinary tract infection, and rash.

The most common side effects of SKYRIZI in people treated for plaque psoriasis
and psoriatic arthritis include: upper respiratory infections, headache, feeling
tired, injection site reactions, and fungal skin infections.

These are not all the possible side effects of SKYRIZI. Call your doctor for
medical advice about side effects.

Use SKYRIZI exactly as your healthcare provider tells you to use it.

SKYRIZI (risankizumab-rzaa) is available in a 150 mg/mL prefilled syringe and
pen, a 600 mg/10 mL vial for intravenous infusion, and a 180 mg/1.2 mL or 360
mg/2.4 mL single-dose prefilled cartridge with on-body injector.

USES

SKYRIZI is a prescription medicine used to treat adults with:

 * moderate to severe plaque psoriasis who may benefit from taking injections or
   pills (systemic therapy) or treatment using ultraviolet or UV light
   (phototherapy).
 * active psoriatic arthritis.
 * moderate to severe Crohn's disease.
 * moderate to severe ulcerative colitis.

US-SKZ-240065

Please see the Full Prescribing Information, including the Medication Guide, for
SKYRIZI.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to
help.
Visit AbbVie.com/PatientAccessSupport to learn more.

Legal Notices. © 2024 AbbVie. All rights reserved. If you have any questions
about AbbVie’s SKYRIZI.com website that have not been answered, click here. This
website and the information contained herein is intended for use by US residents
only, is provided for informational purposes only and is not intended to replace
a discussion with a healthcare provider. All decisions regarding patient care
must be made with a healthcare provider and consider the unique characteristics
of each patient.

Skyrizi Complete Savings Card Terms & Conditions

Eligibility: Available to patients with commercial insurance coverage for
SKYRIZI® (risankizumab-rzaa) who meet eligibility criteria. This co-pay
assistance program is not available to patients receiving prescription
reimbursement under any federal, state, or government-funded insurance programs
(for example, Medicare [including Part D], Medicare Advantage, Medigap,
Medicaid, TRICARE, Department of Defense, or Veterans Affairs programs) or where
prohibited by law. Offer subject to change or termination without notice.
Restrictions, including monthly maximums, may apply. This is not health
insurance. For full Terms and Conditions, visit SKYRIZISavingsCard.com or call
1.866.SKYRIZI for additional information. For full Terms and Conditions for
SKYRIZI Crohn’s Disease and Ulcerative Colitis patients, visit
www.skyrizi.com/savings-card-terms or call 1.866.SKYRIZI for additional
information.  To learn about AbbVie’s privacy practices and your privacy
choices, visit https://abbv.ie/corpprivacy.

SKYRIZI (RISANKIZUMAB-RZAA)

 * Moderate to Severe Plaque Psoriasis
 * Active Psoriatic Arthritis
 * Moderate to Severe Crohn’s Disease
 * Moderate to Severe Ulcerative Colitis
 * About Skyrizi Complete

IMPORTANT SAFETY INFORMATION FOR PATIENTS

 * Important Safety Information
 * Medication Guide
 * Full Prescribing Information

INFORMATION FROM ABBVIE

 * Healthcare Professionals Site
 * Accessibility Statement
 * Contact Us
 * Terms of Use
 * Privacy Notice
 * Consumer Health Data Privacy Notice
 * Cookies Settings
 * Your Privacy Choices



US-SKZ-230238 v1









Leaving AbbVie Web Site

You are leaving the SKYRIZI site and connecting to a site that is not under the
control of AbbVie. AbbVie is not responsible for the contents of any such site
or any further links from such site. AbbVie is providing these links to you only
as a convenience and the inclusion of any link does not imply the endorsement of
the linked site by AbbVie. You should also be aware that the linked site may be
governed by its own set of terms and conditions and privacy policy for which
AbbVie has no responsibility.

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI.com or AbbVie.

Do you wish to leave this site?

Yes
No

US-SKZ-220373

Leaving AbbVie Web Site

You are leaving the SKYRIZI (risankizumab-rzaa) site and connecting to a site
that is not under the control of AbbVie. AbbVie is not responsible for the
contents of any such site or any further links from such site. AbbVie is
providing these links to you only as a convenience and the inclusion of any link
does not imply the endorsement of the linked site by AbbVie. You should also be
aware that the linked site may be governed by its own set of terms and
conditions and privacy policy for which AbbVie has no responsibility.

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090

Leaving AbbVie Web Site

You are about to enter a site that is for US healthcare professionals only. By
continuing, you certify that you are a healthcare professional and that you wish
to proceed to the healthcare professionals section of this site. Products or
treatments described on this site are available in the US but may not be
available in all other countries.

Iam a licensed healthcare professional and wish to proceed to the healthcare
professionals section of this site.

Yes
No

US-RISN-190090

Leaving AbbVie Web Site

You are leaving the SKYRIZI (risankizumab-rzaa) site and connecting to a site
that is not under the control of AbbVie. AbbVie is not responsible for the
contents of any such site or any further links from such site. AbbVie is
providing these links to you only as a convenience and the inclusion of any link
does not imply the endorsement of the linked site by AbbVie. You should also be
aware that the linked site may be governed by its own set of terms and
conditions and privacy policy for which AbbVie has no responsibility.

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090

Leaving AbbVie Web Site

You are leaving the SKYRIZI (risankizumab-rzaa) site and connecting to a site
that is not under the control of AbbVie. AbbVie is not responsible for the
contents of any such site or any further links from such site. AbbVie is
providing these links to you only as a convenience and the inclusion of any link
does not imply the endorsement of the linked site by AbbVie. You should also be
aware that the linked site may be governed by its own set of terms and
conditions and privacy policy for which AbbVie has no responsibility.

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090

Leaving AbbVie Web Site

You are leaving the SKYRIZI (risankizumab-rzaa) site and connecting to a site
that is not under the control of AbbVie. AbbVie is not responsible for the
contents of any such site or any further links from such site. AbbVie is
providing these links to you only as a convenience and the inclusion of any link
does not imply the endorsement of the linked site by AbbVie. You should also be
aware that the linked site may be governed by its own set of terms and
conditions and privacy policy for which AbbVie has no responsibility.

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090



Leaving AbbVie Website

You are leaving the SKYRIZI site and connecting to a site that is not under the
control of AbbVie. AbbVie is not responsible for the contents of any such site
or any further links from such site. AbbVie is providing these links to you only
as a convenience and the inclusion of any link does not imply the endorsement of
the linked site by AbbVie. You should also be aware that the linked site may be
governed by its own set of terms and conditions and privacy policy for which
AbbVie has no responsibility.

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI.com or AbbVie.

Do you wish to leave this site?

Yes
No

US-SKZ-230238 v1

Leaving AbbVie Web Site

You are leaving the SKYRIZI (risankizumab-rzaa) site and connecting to a site
that is not under the control of AbbVie. AbbVie is not responsible for the
contents of any such site or any further links from such site. AbbVie is
providing these links to you only as a convenience and the inclusion of any link
does not imply the endorsement of the linked site by AbbVie. You should also be
aware that the linked site may be governed by its own set of terms and
conditions and privacy policy for which AbbVie has no responsibility.

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090

Leaving AbbVie Web Site

You are leaving the SKYRIZI (risankizumab-rzaa) site and connecting to a site
that is not under the control of AbbVie. AbbVie is not responsible for the
contents of any such site or any further links from such site. AbbVie is
providing these links to you only as a convenience and the inclusion of any link
does not imply the endorsement of the linked site by AbbVie. You should also be
aware that the linked site may be governed by its own set of terms and
conditions and privacy policy for which AbbVie has no responsibility.

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090

Important Updates to the Medication Guide for
SKYRIZI® (risankizumab-rzaa) injection, for subcutaneous use

On January 21, 2022, the SKYRIZI (risankizumab-rzaa) Prescribing Information and
Medication Guide were updated to include new information about serious allergic
reactions. 

The following describes the recent changes to the SKYRIZI Medication Guide.
Please refer to the full Prescribing Information and Medication Guide for
additional safety information.

The following serious side effects were added to the section “What is the most
important information I should know about SKYRIZI?”

SKYRIZI may cause serious side effects, including: 

Serious allergic reactions. Stop using SKYRIZI and get emergency medical help
right away if you get any of the following symptoms of a serious allergic
reaction:

 * fainting, dizziness, feeling lightheaded (low blood pressure)
 * swelling of your face, eyelids, lips, mouth, tongue, or throat
 * trouble breathing or throat tightness
 * chest tightness
 * skin rash, hives
 * itching

Who should not use SKYRIZI?

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the
ingredients in SKYRIZI. See the end of the Medication Guide for a complete list
of ingredients in SKYRIZI here.

This is not a complete list of all the changes made to the Prescribing
Information and Medication Guide for SKYRIZI. Please refer to the full
Prescribing Information and Medication Guide for additional safety information.

INDICATIONS1

SKYRIZI is a prescription medicine used to treat adults: 

• with moderate to severe plaque psoriasis who may benefit from taking
injections or pills (systemic therapy) or treatment using ultraviolet or UV
light (phototherapy). 

• with active psoriatic arthritis (PsA).

Important Safety Information1

What is the most important information I should know about SKYRIZI®
(risankizumab-rzaa)?

SKYRIZI is a prescription medicine that may cause serious side effects,
including:

Serious allergic reactions:

• Stop using SKYRIZI and get emergency medical help right away if you get any of
the following symptoms of a serious allergic reaction:

− fainting, dizziness, feeling lightheaded (low blood pressure)

− swelling of your face, eyelids, lips, mouth, tongue, or throat

− trouble breathing or throat tightness

− chest tightness

− skin rash, hives

− itching

Infections:

SKYRIZI may lower the ability of your immune system to fight infections and may
increase your risk of infections. Your healthcare provider should check you for
infections and tuberculosis (TB) before starting treatment with SKYRIZI and may
treat you for TB before you begin treatment with SKYRIZI if you have a history
of TB or have active TB. Your healthcare provider should watch you closely for
signs and symptoms of TB during and after treatment with SKYRIZI.

• Tell your healthcare provider right away if you have an infection or have
symptoms of an infection, including:

− fever, sweats, or chills

− cough

− shortness of breath

− blood in your mucus (phlegm)

− muscle aches

− warm, red, or painful skin or sores on your body different from your psoriasis

− weight loss

− diarrhea or stomach pain

− burning when you urinate or urinating more often than normal

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the
ingredients in SKYRIZI.

Before using SKYRIZI, tell your healthcare provider about all of your medical
conditions, including if you:

• have any of the conditions or symptoms listed in the section “What is the most
important information I should know about SKYRIZI?”

• have an infection that does not go away or that keeps coming back.

• have TB or have been in close contact with someone with TB.

• have recently received or are scheduled to receive an immunization (vaccine).
Medications that interact with the immune system may increase your risk of
getting an infection after receiving live vaccines. You should avoid receiving
live vaccines right before, during, or right after treatment with SKYRIZI. Tell
your healthcare provider that you are taking SKYRIZI before receiving a vaccine.

• are pregnant or plan to become pregnant. It is not known if SKYRIZI can harm
your unborn baby.

• are breastfeeding or plan to breastfeed. It is not known if SKYRIZI passes
into your breast milk.

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of SKYRIZI?

SKYRIZI may cause serious side effects. See “What is the most important
information I should know about SKYRIZI?”

The most common side effects of SKYRIZI include upper respiratory infections,
feeling tired, fungal skin infections, headache, and injection site reactions.

These are not all the possible side effects of SKYRIZI. Call your doctor for
medical advice about side effects.

Use SKYRIZI exactly as your healthcare provider tells you to use it.

SKYRIZI is available in a 150 mg/mL prefilled syringe and pen.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to
help. Visit AbbVie.com/myAbbVieAssist to learn more.

Please see accompanying full Prescribing Information or visit
www.rxabbvie.com/pdf/skyrizi_pi.pdf.

Reference: 1. SKYRIZI [package insert]. North Chicago, IL: AbbVie Inc.
©2022 AbbVie. All rights reserved. US-SKZD-220015 January 2022

US-SKZ-220001

Leaving AbbVie Web Site

You are leaving the SKYRIZI (risankizumab-rzaa) site and connecting to a site
that is not under the control of AbbVie. AbbVie is not responsible for the
contents of any such site or any further links from such site. AbbVie is
providing these links to you only as a convenience and the inclusion of any link
does not imply the endorsement of the linked site by AbbVie. You should also be
aware that the linked site may be governed by its own set of terms and
conditions and privacy policy for which AbbVie has no responsibility.

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090





USES

SKYRIZI is a prescription medicine used to
treat adults with:

 * moderate to severe plaque psoriasis who may benefit from taking injections or
   pills (systemic therapy) or treatment using ultraviolet or UV light
   (phototherapy).

 * active psoriatic arthritis.


IMPORTANT SAFETY INFORMATION

SKYRIZI is a prescription medicine that may cause serious side effects,
including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help
right away if you get any of the following symptoms of a serious allergic
reaction:

• fainting, dizziness, feeling lightheaded (low blood pressure) • swelling of
face, eyelids, lips, mouth, tongue, or throat • trouble breathing or throat
tightness • chest tightness • skin rash, hives • itching

Infections: SKYRIZI may lower the ability of your immune system to fight
infections and may increase


IMPORTANT SAFETY INFORMATION & USES

SKYRIZI is a prescription medicine that may cause serious side effects,
including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help
right away if you develop a serious allergic reaction.

Infections: SKYRIZI may lower your ability to fight infections and may increase
risk of infections. Your healthcare provider should check you for infections and
tuberculosis (TB)


USES

SKYRIZI is a prescription medicine used to
treat adults with:

 * moderate to severe plaque psoriasis who may benefit from taking injections or
   pills (systemic therapy) or treatment using ultraviolet or UV light
   (phototherapy).

 * active psoriatic arthritis.


IMPORTANT SAFETY INFORMATION

SKYRIZI is a prescription medicine that may cause serious side effects,
including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help
right away if you get any of the following symptoms of a serious allergic
reaction:

• fainting, dizziness, feeling lightheaded (low blood pressure) • swelling of
face, eyelids, lips, mouth, tongue, or throat • trouble breathing or throat
tightness • chest tightness • skin rash, hives • itching

Infections: SKYRIZI may lower the ability of your immune system to fight
infections and may increase


IMPORTANT SAFETY INFORMATION & USES

SKYRIZI is a prescription medicine that may cause serious side effects,
including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help
right away if you develop a serious allergic reaction.

Infections: SKYRIZI may lower your ability to fight infections and may increase
risk of infections. Your healthcare provider should check you for infections and
tuberculosis (TB)


USES

SKYRIZI is a prescription medicine used to treat adults with:

 * moderate to severe plaque psoriasis who may benefit from taking injections or
   pills (systemic therapy) or treatment using ultraviolet or UV light
   (phototherapy).
 * active psoriatic arthritis.
 * moderate to severe Crohn's disease.
 * moderate to severe ulcerative colitis.


IMPORTANT SAFETY INFORMATION

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT SKYRIZI®
(RISANKIZUMAB-RZAA)?

SKYRIZI IS A PRESCRIPTION MEDICINE THAT MAY CAUSE SERIOUS SIDE EFFECTS,
INCLUDING:

SERIOUS ALLERGIC REACTIONS:

 * Stop using SKYRIZI and get emergency medical help right away if you get any
   of the following symptoms of a serious allergic reaction:
   * - fainting, dizziness, feeling lightheaded
     (low blood pressure)
   * - swelling of your face, eyelids, lips, mouth,
     tongue, or throat
   * - trouble breathing or throat tightness
   * - chest tightness
   * - skin rash, hives
   * - itching

INFECTIONS:

SKYRIZI may lower the ability of your immune system to fight infections and may
increase your risk of infections. Your healthcare provider should check you for
infections and tuberculosis (TB) before starting treatment with SKYRIZI and may
treat you for TB before you begin treatment with SKYRIZI if you have a history
of TB or have active TB. Your healthcare provider should watch you closely for
signs and symptoms of TB during and after treatment with SKYRIZI.

 * Tell your healthcare provider right away if you have an infection or have
   symptoms of an infection, including:
   * - fever, sweats, or chills
   * - cough
   * - shortness of breath
   * - blood in your mucus (phlegm)
   * - muscle aches
   * - warm, red, or painful skin
     or sores on your body different from your psoriasis
   * - weight loss
   * - diarrhea or stomach pain
   * - burning when you urinate or urinating more often than normal

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the
ingredients in SKYRIZI. See the Medication Guide or Consumer Brief Summary for a
complete list of ingredients.

BEFORE USING SKYRIZI, TELL YOUR HEALTHCARE PROVIDER ABOUT ALL OF YOUR MEDICAL
CONDITIONS, INCLUDING IF YOU:

 * have any of the conditions or symptoms listed in the section "What is the
   most important information I should know about SKYRIZI?"
 * have an infection that does not go away or that keeps coming back.
 * have TB or have been in close contact with someone with TB.
 * have recently received or are scheduled to receive an immunization (vaccine).
   Medicines that interact with the immune system may increase your risk of
   getting an infection after receiving live vaccines. You should avoid
   receiving live vaccines right before, during, or right after treatment with
   SKYRIZI. Tell your healthcare provider that you are taking SKYRIZI before
   receiving a vaccine.
 * are pregnant or plan to become pregnant. It is not known if SKYRIZI can harm
   your unborn baby.
 * are breastfeeding or plan to breastfeed. It is not known if SKYRIZI passes
   into your breast milk.
 * become pregnant while taking SKYRIZI. You are encouraged to enroll in the
   Pregnancy Registry, which is used to collect information about the health of
   you and your baby. Talk to your healthcare provider or call 1-877-302-2161 to
   enroll in this registry.

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.

WHAT ARE THE POSSIBLE SIDE EFFECTS OF SKYRIZI?

SKYRIZI may cause serious side effects. See "What is the most important
information I should know about SKYRIZI?"

Liver problems may happen while being treated for Crohn's disease or ulcerative
colitis: A person with Crohn's disease who received SKYRIZI through a vein in
the arm developed changes in liver blood tests with a rash that led to
hospitalization. Your healthcare provider will do blood tests to check your
liver before, during, and at least up to 12 weeks of treatment, and may stop
treatment with SKYRIZI if you develop liver problems. Tell your healthcare
provider right away if you notice any of the following symptoms: unexplained
rash, nausea, vomiting, stomach (abdominal) pain, tiredness (fatigue), loss of
appetite, yellowing of the skin and eyes (jaundice), and dark urine.

The most common side effects of SKYRIZI in people treated for Crohn’s disease
and ulcerative colitis include: upper respiratory infections, headache, joint
pain, stomach (abdominal) pain, injection site reactions, low red blood cells
(anemia), fever, back pain, urinary tract infection, and rash.

The most common side effects of SKYRIZI in people treated for plaque psoriasis
and psoriatic arthritis include: upper respiratory infections, headache, feeling
tired, injection site reactions, and fungal skin infections.

These are not all the possible side effects of SKYRIZI. Call your doctor for
medical advice about side effects.

Use SKYRIZI exactly as your healthcare provider tells you to use it.

SKYRIZI (risankizumab-rzaa) is available in a 150 mg/mL prefilled syringe and
pen, a 600 mg/10 mL vial for intravenous infusion, and a 180 mg/1.2 mL or 360
mg/2.4 mL single-dose prefilled cartridge with on-body injector.

USES

SKYRIZI is a prescription medicine used to treat adults with:

 * moderate to severe plaque psoriasis who may benefit from taking injections or
   pills (systemic therapy) or treatment using ultraviolet or UV light
   (phototherapy).
 * active psoriatic arthritis.
 * moderate to severe Crohn's disease.
 * moderate to severe ulcerative colitis.

US-SKZ-240065



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