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Pancreas Carcinoma

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PANCREAS CARCINOMA

By Eva Karamitopoulou-Diamantis July 10, 2021June 11, 2022


WELCOME TO PANCREAS CARCINOMA


RECENT PROJECTS

In general, our research projects are focused on understanding how the immune
response patterns within the microenvironment of pancreatic cancer shape and are
shaped by the genetic alterations and the transcriptional activity of the tumor
cells. Our objective is to provide biomarkers, which would serve as targets in
order to enhance the power of immunotherapy and/or conventional therapy for
pancreatic cancer and improve patient outcomes.

Eva Karamitopoulou-DiamantisMay 2, 2023


PATHOLOGY OF THE PANCREAS – SPRINGER NATURE

Pathology of the Pancreas is a new encyclopedia volume covering the complete
field of pancreatic pathology, edited by Irene Esposito and Eva
Karamitopoulou-Diamantis. The book, published by Springer Nature in November
2022, comprises 230 pagesContinue readingPancreas Carcinoma

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Eva Karamitopoulou-DiamantisMay 2, 2023


SPATIALLY RESTRICTED TUMOUR-ASSOCIATED AND HOST-ASSOCIATED IMMUNE DRIVERS
CORRELATE WITH THE RECURRENCE SITES OF PANCREATIC CANCER

This study published in Gut journal investigated the spatially organised immune
determinants of pancreatic ductal adenocarcinoma (PDAC) recurrence. The study
analyzed PDACs from 284 patients and classified them according to recurrence
sites. Spatial compartments wereContinue readingPancreas Carcinoma

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Eva Karamitopoulou-DiamantisMay 2, 2022


TUMOR MUTATIONAL BURDEN IN PANCREATIC CANCER

Programmed death receptor-1/ligand 1 (PD-1/L1) antibodies can induce durable
remissions and improved outcomes in many malignancies. However, response rates
are low in unselected patients, as compared with selected groups such as
patients with microsatellite instability–highContinue readingPancreas Carcinoma

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Eva Karamitopoulou-DiamantisMarch 16, 2022


PD-1/PD-L1 IMMUNOARCHITECTURAL PATTERNS IN PANCREATIC CANCER

Pancreatic ductal adenocarcinoma (PDAC) is considered immunologically “cold” and
treatment with immune checkpoint blockade targeting PD-1/PD-L1 is only effective
in a subset of patients. Here we used an automated system, in addition to
next-generation sequencing,Continue readingPancreas Carcinoma

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Eva Karamitopoulou-DiamantisMarch 16, 2022


MOLECULAR PATHOLOGY OF PANCREATIC CANCER

Pancreatic ductal adenocarcinoma (PDAC) is a biologically aggressive malignancy
showing a remarkable resistance to existing therapies and is often diagnosed at
an advanced stage, leaving only about 15–20% of patients with an option for
surgicalContinue readingPancreas Carcinoma

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