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LATEST FROM BRITISH MEDICAL JOURNAL

British Medical Journal

ARTIFICIAL SWEETENERS AND RISK OF CARDIOVASCULAR DISEASES: RESULTS FROM THE
PROSPECTIVE NUTRINET-SANTÉ COHORT

In a prospective study following the diet and activity records of more than
100,000 individuals in France, artificial sweeteners were positively correlated
with cardiovascular diseases. Analyzing 900,000 person-years of data showed:
Total artificial sweetener intake was associated with CVD risk Artificial
sweeteners were more strongly associated with cerebrovascular disease Aspartame
was associated with increase cerebrovascular events Acesulfame K and sucralose
were associated with increased coronary heart disease risk

Cardiology September 13th 2022

Tags: CARDIOVASCULAR DISEASE (CVD) CARDIOVASCULAR EVENTS CLINICAL STUDY FOOD &
DIET

British Medical Journal

ASSOCIATION OF ULTRA-PROCESSED FOOD CONSUMPTION WITH COLORECTAL CANCER RISK
AMONG MEN AND WOMEN: RESULTS FROM THREE PROSPECTIVE US COHORT STUDIES

Over a 24-year-period, more than 200,000 men (n=46,341) and women (n=159,907)
had dietary intake assessments performed every four years via survey. During the
period, 3,216 CRC cancer cases were reported. Men with the highest 20% of
ultra-processed food consumption had a 29% higher risk of developing colorectal
cancer. For women, no association was seen between ultra-processed food
consumption and risk of CRC. Ready-to-eat meat products and sugar-sweetened
drinks among men and ready-to-eat/heat mixed dishes among women had the highest
risk of CRC. Yogurt and dairy-based desserts had a negative associated risk for
women.

Oncology, Medical September 12th 2022

Tags: CLINICAL STUDY COLORECTAL CANCER (CRC) FOOD & DIET

British Medical Journal

YOUNG WOMEN AND ANAL SEX

Anal intercourse is becoming more common among heterosexual couples. In the US,
30-44% of men and women report experience of anal sex. There are a host
ofnegative health implications, especially for women, that should be
communicatedespecially so patients can make truly informed decisions.

Family Medicine/General Practice August 17th 2022

Tags: PAIN SEXUAL HEALTH WOMEN'S HEALTH

British Medical Journal

RESPONSE TO ACUTE MONOTHERAPY FOR MAJOR DEPRESSIVE DISORDER IN RANDOMIZED,
PLACEBO CONTROLLED TRIALS SUBMITTED TO THE US FOOD AND DRUG ADMINISTRATION:
INDIVIDUAL PARTICIPANT DATA ANALYSIS

Study: This meta-analysis includes 232 randomized, double-blind,
placebo-controlled trials of drug monotherapy for major depressive disorder
submitted to the FDA between 1979 and 2016, and comprises nearly 75,000 adult
and child participants. Conclusion: Patients with depression are likely to
improve substantially from acute treatment of their depression with drug or
placebo. Although the mean effect of antidepressants is only a small improvement
over placebo, the effect of active drug seems to increase the probability that
any patient will benefit substantially from treatment by about 15%.

Psychiatry August 8th 2022

Tags: CLINICAL TRIALS DEPRESSION FDA

British Medical Journal

CLINICAL FEATURES AND NOVEL PRESENTATIONS OF HUMAN MONKEYPOX IN A CENTRAL LONDON
CENTRE DURING THE 2022 OUTBREAK: DESCRIPTIVE CASE SERIES

A detailed summarization of the clinical presentation of 197 individuals with
PCR-confirmed diagnosis of monkeypox in the UK. The summary documents a highly
variable prodrome in terms of prodromal symptoms and timing to eruption of
visible lesions. Systemic illness was seen in 86% of patients. After
mucocutaneous lesions, seen in 100% of patients, fever was the next most common
manifestation, seen in 62% of patients.

All Specialties August 4th 2022

Tags: CLINICAL STUDY INFECTIOUS DISEASES PUBLIC HEALTH

British Medical Journal

“NO CONVINCING EVIDENCE” THAT DEPRESSION IS CAUSED BY LOW SEROTONIN LEVELS, SAY
STUDY AUTHORS

The idea that depression is brought on by decreased serotonin activity or
concentrations is unsupported, according to the authors of a systematic umbrella
review, who also challenge the rationale behind the high rates of antidepressant
prescription. They claim that certain medical professionals continue to promote
the incorrect chemical imbalance explanation of depression, and the public as a
whole still accepts it. However, other medical professionals argue that
antidepressants continue to be a helpful treatment option for patients in
addition to other methods like talking therapy and that the idea that depression
is caused by a straightforward chemical imbalance is outdated in any case.

Psychiatry July 26th 2022

Tags: CLINICAL STUDY DEPRESSION MENTAL HEALTH
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