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Advertisement * * news * careers * commentary * Journals * Covid-19 * * * Log in * Subscribe science science advances science immunology science robotics science signaling science translational medicine science partner journals Quick Search anywhere Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Quick Search in Journals Enter Search Term Searching: Anywhere AnywhereScienceScience AdvancesScience ImmunologyScience RoboticsScience SignalingScience Translational Medicine Advanced Search Search TRENDING TERMS: * covid-19 * climate * monkeypox * abortion * perovskite Log In Subscribe Quick Search anywhere Enter Search Term science.org * news * careers * commentary * Journals * science * science advances * science immunology * science robotics * science signaling * science translational medicine * science partner journals * Custom publishing * collections * videos * podcasts * blogs * visualizations * prizes and awards * authors & reviewers * librarians * advertisers * about * help * * * * * * * Terms of Service * Privacy Policy * Accessibility * News * Careers * Commentary * Journals * Covid-19 GET OUR E-ALERTS Science Signaling16 May 2023 TOXIN-INDUCED JUNCTION DYSFUNCTION * Shuang Sun * Zhaoyang Xu * et al. A Bacillus cereus toxin compromises epithelial cell junctions by perturbing microtubule dynamics. Science Immunology12 May 2023 TRANSCRIPTIONAL REGULATION OF CD4 TRM By * Quynh P. Nguyen * Kennidy K. Takehara * et al. Science Translational Medicine10 May 2023 A COVID-19 VACCINE GENERATES NEUTRALIZING ANTIBODIES AGAINST SARBECOVIRUSES By * Yupeng Feng * Meng Yuan * et al. Science11 May 2023 FREE-DIVING SHARKS By * Mark Meekan * Adrian Gleiss Science Advances10 May 2023 SECURELY STORING DATA AS DNA IN A HYDROGEL By * Zhongjie Fei * Nupur Gupta * et al. Science Robotics10 May 2023 RECORDING CORTICAL BRAIN ACTIVITY WITH EVERTING ELECTRODES By * Maria Asplund LATEST NEWS 17 May 2023 Watch this spider crawl like an ant to avoid being eaten 16 May 2023 Failed cancer therapy revived as powerful tumor killer when combined with newer drugs 16 May 2023 Damage delays restart of Italy’s giant gravitational wave detector 16 May 2023 After outcry, disgraced sexual harasser removed from astronomy manuscript 15 May 2023 Weird alien world may be a planetary sauna 15 May 2023 Biden nominates Monica Bertagnolli to lead National Institutes of Health … science is what we know now, the product of the work of many people over time … * Editor’s Blog * 11 May 2023 * H. Holden Thorp ADVERTISEMENT ADVERTISEMENT FIRST RELEASE Science Immunology16 May 2023 EFFICACY OF MRNA-1273 AND NOVAVAX ANCESTRAL OR BA.1 SPIKE BOOSTER VACCINES AGAINST SARS-COV-2 BA.5 INFECTION IN NON-HUMAN PRIMATES Science11 May 2023 CONSTRAINTS ON THE HUBBLE CONSTANT FROM SUPERNOVA REFSDAL’S REAPPEARANCE Science11 May 2023 CORRELATED INSULATOR OF EXCITONS IN WSE2/WS2 MOIRÉ SUPERLATTICES Science4 May 2023 FEMTOSECOND SYMMETRY BREAKING AND COHERENT RELAXATION OF METHANE CATIONS VIA X-RAY SPECTROSCOPY Science4 May 2023 DISCOVERY OF TARGET GENES AND PATHWAYS AT GWAS LOCI BY POOLED SINGLE-CELL CRISPR SCREENS Science Immunology14 Jun 2022 VACCINE BREAKTHROUGH HYPOXEMIC COVID-19 PNEUMONIA IN PATIENTS WITH AUTO-ABS NEUTRALIZING TYPE I IFNS SCIENCE * Volume 380 * Issue 6645 * May 2023 View Cover COVER Scalloped hammerhead sharks (Sphyrna lewini) form daytime schools near the ocean’s surface and, at night, dive into cold, deep waters to hunt deep-sea prey. They keep warm while deep diving by closing their gills—effectively holding their breath. This foraging strategy is similar to strategies used by deep-diving marine mammals. See pages 583 and 651. Photo: Brandon Cole Research ArticlesBy * I. Liodakis * K. I. I. Koljonen * et al. OPTICAL POLARIZATION FROM COLLIDING STELLAR STREAM SHOCKS IN A TIDAL DISRUPTION EVENT Research ArticlesBy * Reshma Anna-Thomas * Liam Connor * et al. MAGNETIC FIELD REVERSAL IN THE TURBULENT ENVIRONMENT AROUND A REPEATING FAST RADIO BURST Research ArticlesBy * Elke Zeller * Axel Timmermann * et al. HUMAN ADAPTATION TO DIVERSE BIOMES OVER THE PAST 3 MILLION YEARS Working LifeBy * Alex Hubert SPACE TO MEDITATE View Table of Contents SCIENCE ADVANCES * Volume 9 * Issue 19 * May 2023 View Cover ONLINE COVER Light refracted from a single spherulite composed of many lamellar structures and millions of unit cells. Semicrystalline polymers, such as polyethylene oxide (PEO), are only supposed to flow above their melting point, which affects how these materials, and by extension, the technologies that use them are processed and produced. Tu et al. demonstrate that by using capillary action, these polymers can be made to flow below their melting point, while still preserving the polymer crystallites. The unexpected enhancement in flow is important in the design of new polymer processing conditions applicable at low temperatures, for instance, in organic electronics. Credit: Chien-Hua Tu Biomedicine and Life SciencesBy * Max A. Winkelman * Guohao Dai BIOENGINEERED PERFUSED HUMAN BRAIN MICROVASCULAR NETWORKS ENHANCE NEURAL PROGENITOR CELL SURVIVAL, NEUROGENESIS, AND MATURATION Physical and Materials SciencesBy * Chika Imaoka * Tasuku Nakajima * et al. INVERSE MECHANICAL-SWELLING COUPLING OF A HIGHLY DEFORMED DOUBLE-NETWORK GEL Social and Interdisciplinary SciencesBy * Aparna Balagopalan * David Madras * et al. JUDGING FACTS, JUDGING NORMS: TRAINING MACHINE LEARNING MODELS TO JUDGE HUMANS REQUIRES A MODIFIED APPROACH TO LABELING DATA Social and Interdisciplinary SciencesBy * Tobias Haueise * Fritz Schick * et al. ANALYSIS OF VOLUME AND TOPOGRAPHY OF ADIPOSE TISSUE IN THE TRUNK: RESULTS OF MRI OF 11,141 PARTICIPANTS IN THE GERMAN NATIONAL COHORT View Table of Contents SCIENCE IMMUNOLOGY * Volume 8 * Issue 83 * May 2023 View Cover ONLINE COVER Advances in Understanding Allergic Asthma. This month’s cover features a photograph of a young man using an inhaler. Inhaled drugs are widely used by patients with allergic asthma to treat disease exacerbations after aeroallergen exposure. Alladina and Smith et al. used segmental allergen challenge of volunteers with either allergic asthma or just allergy to compare the responses of airway cells collected 24 hours after intrapulmonary allergen challenge. Single-cell profiling identified distinct cellular circuits in the allergic controls without asthma group that provide clues as to how these individuals can tolerate allergen exposure, avoiding activation of pathogenic TH2 cells and progression to impaired airway function. The potential application of these findings to the design of therapeutic interventions for asthma patients is discussed in an accompanying Focus by Gay and Nawijn. Credit: SeventyFour/Shutterstock Editors' ChoiceBy * Thomas Guy * Shiv Pillai “AGE COULD NOT WITHER HER…” BECAUSE OF HER CYTOTOXIC CD4+ T CELLS? Research ArticlesBy * Lihong Wang-Bishop * Blaise R. Kimmel * et al. STING-ACTIVATING NANOPARTICLES NORMALIZE THE VASCULAR-IMMUNE INTERFACE TO POTENTIATE CANCER IMMUNOTHERAPY FocusBy * Aurore C. A. Gay * Martijn C. Nawijn SEE NO ALLERGEN, HEAR NO ALLERGEN, SPEAK NO ALLERGEN! Research ArticlesBy * Anis Barmada * Jon Klein * et al. CYTOKINOPATHY WITH ABERRANT CYTOTOXIC LYMPHOCYTES AND PROFIBROTIC MYELOID RESPONSE IN SARS-COV-2 MRNA VACCINE–ASSOCIATED MYOCARDITIS View Table of Contents SCIENCE ROBOTICS * Volume 8 * Issue 78 * May 2023 View Cover ONLINE COVER Special issue on brain-inspired and brain-interfacing robots. The ability of robots to recognize places is crucial for interacting with their environment. Inspired by the multimodal sensory processing by the brain, Fangwen Yu et al. have developed a general place recognition system that relies on multiple sensors, in combination with multimodal hybrid neural network, and neuromorphic computing. The system was deployed on a legged robot and shown to be capable of accurately recognizing places indoors and outdoors. This month’s cover is an image of the place recognition system onboard a legged robot in a forest. Credit: Luping et al./Science Robotics FocusBy * Maria Asplund ACCESSING THE BRAIN WITH SOFT DEPLOYABLE ELECTROCORTICOGRAPHY ARRAYS Research ArticlesBy * Fangwen Yu * Yujie Wu * et al. BRAIN-INSPIRED MULTIMODAL HYBRID NEURAL NETWORK FOR ROBOT PLACE RECOGNITION Research ArticlesBy * Sukho Song * Florian Fallegger * et al. DEPLOYMENT OF AN ELECTROCORTICOGRAPHY SYSTEM WITH A SOFT ROBOTIC ACTUATOR View Table of Contents SCIENCE SIGNALING * Volume 16 * Issue 785 * May 2023 View Cover ONLINE COVER This week, Sun et al. report that the Bacillus cereus toxin alveolysin compromises the intestinal epithelial barrier by interfering with cell junctions. The image shows disrupted villi in the intestine of a mouse orally inoculated with B. cereus strain Bc-5. Credit: Sun et al./Science Signaling Editors' ChoiceBy * Amy E. Baek NEURONAL-GLIOMA CROSS-TALK Research ArticleBy * Shuang Sun * Zhaoyang Xu * et al. THE BACILLUS CEREUS TOXIN ALVEOLYSIN DISRUPTS THE INTESTINAL EPITHELIAL BARRIER BY INDUCING MICROTUBULE DISORGANIZATION THROUGH CFAP100 View Table of Contents SCIENCE TRANSLATIONAL MEDICINE * Volume 15 * Issue 695 * May 2023 View Cover ONLINE COVER Improving ICIs. This image of a tumor biopsy from a patient with triple negative breast cancer shows increased presence of CD8+ T cells (yellow) and proliferating cells (purple) after treatment with a combination of RO7122290 and the immune checkpoint inhibitor (ICI) atezolizumab. Melero et al. performed a first-in-human study of RO7122290, a bispecific antibody-like protein that targets fibroblast activation protein-α (FAP) and functions as a 4-1BB agonist designed to co-stimulate CD8+ T cells within the tumor. Patients with advanced or metastatic solid tumors expressing FAP were treated with RO7122290 either as a single agent or in combination with atezolizumab, which resulted in an increase in proliferating and activated CD8+ T cells in the blood and tumor tissue. Eleven patients achieved a complete or partial response, supporting further study of RO7122290 in combination with ICIs to treat solid tumors. Credit: Melero et al./Science Translational Medicine Research ArticlesBy * Ignacio Melero * Tamara Tanos * et al. A FIRST-IN-HUMAN STUDY OF THE FIBROBLAST ACTIVATION PROTEIN–TARGETED, 4-1BB AGONIST RO7122290 IN PATIENTS WITH ADVANCED SOLID TUMORS Research ArticlesBy * Elmira Esmaeilzadeh * Behzad Etemad * et al. AUTOLOGOUS NEUTRALIZING ANTIBODIES INCREASE WITH EARLY ANTIRETROVIRAL THERAPY AND SHAPE HIV REBOUND AFTER TREATMENT INTERRUPTION Research ArticlesBy * Michiyo Iba * Changyoun Kim * et al. INHIBITION OF P38Α MAPK RESTORES NEURONAL P38Γ MAPK AND AMELIORATES SYNAPTIC DEGENERATION IN A MOUSE MODEL OF DLB/PD Research ArticlesBy * Wei Shi * Yin Wang * et al. IMMUNE CHECKPOINT B7-H3 IS A THERAPEUTIC VULNERABILITY IN PROSTATE CANCER HARBORING PTEN AND TP53 DEFICIENCIES View Table of Contents Skip slideshow CUSTOM PUBLISHING SPONSORED webinar Go with the flow: Advancing cell and gene therapy with flow cytometry By * Erika Gebel Berg, Ph.D. * , et al. SPONSORED webinar A transfer of power: The cell-to-cell exchange of mitochondria in obesity and aging By * Erika Gebel Berg, Ph.D. * , et al. SPONSORED webinar Single cell in situ spatial profiling reveals novel insights into cellular and molecular dysregulation in pulmonary fibrosis By * Jackie Oberst, Ph.D. * , et al. SPONSORED webinar Using single-cell and spatial transcriptomics to dissect cellular heterogeneity during melanoma growth and metastasis By * Jackie Oberst, Ph.D. * , et al. 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