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SERVING THE IO AND CELL THERAPY COMMUNITY 

 * Webcasts
 * Immuno-Oncology and Cell Therapy


FIRESIDE CHAT: THE FUTURE OF CAR-T, CELL THERAPY, T-CELL ENGAGERS AND SYNTHETIC
IMMUNITY

This fireside chat webcast will delve into the distinct contrasts in
functionality and future prospects of CAR-T and T-Cell Engagers (TCE) as single
agents and in combination therapies.

January 23, 2024, 12:00 PM

Register Now

Registration is complimentary and required to attend.

Synthetic immune approaches remain at the forefront, offering precise and
powerful strategies for targeting and eliminating cancer cells. This webcast
will delve into the distinct contrasts in functionality and future prospects of
CAR-T and T-Cell Engagers (TCE) as single agents and in combination therapies.
Exploring how these approaches function, the discussion will focus on shedding
light on the unique features of CAR-T and TCE and what lies ahead for their
application in the evolving landscape of cancer treatment, particularly in
addressing solid tumors. While both utilize a T cell’s killing machinery,
understanding these contrasts is crucial for shaping the future of cancer
immunotherapy.


Learning Objectives:

 * Gain insights into the shared and contrasting mechanisms, technologies, and
   approaches in CAR-T and TCE
 * Identify the unique features and future prospects of CAR-T and TCE as single
   agents and in combination therapies
 * Explore the implications of these contrasts in addressing the challenges of
   solid tumor treatment
 * Deepen understanding of the evolving landscape of cancer immunotherapy and
   the role of CAR-T and TCE in shaping its future



Speakers


DANIEL S CHEN, MD, PHD

Founder

Engenuity Life Sciences


DANIEL S CHEN, MD, PHD

Founder
Engenuity Life Sciences

Daniel S Chen, MD, PhD, is the founder of Engenuity Life Sciences, former Vice
President, Global Head of Cancer Immunotherapy Development at Genentech/Roche
and former Chief Medical Officer for IGM Biosciences. He received a BS degree in
Biology from the Massachusetts Institute of Technology (1990), a PhD in
Microbiology & Immunology (1996) and MD (1998) from the University of Southern
California. His PhD work and publications focused on “Early Events in
Coronavirus Infection.” Dr Chen completed an Internal Medicine Residency and
Medical Oncology Fellowship at Stanford University (2003). He went on to
complete a Post-doctoral fellowship with Mark Davis in Immunology, where he was
a Howard Hughes Medical Institute Associate. He also ran the metastatic melanoma
clinic at the Stanford Cancer Center from 2003-2006. In that time, he studied
human anti-cancer immune responses pre- and post- cancer vaccination and
cytokine administration to determine why anti-tumor immune responses were not
more clinically effective. He received a U19 grant to develop better immunologic
tools to interrogate human immune responses and ultimately patented the MHC
cellular microarray to detect and functionally characterize antigen-specific T
cell states. He continued as Adjunct Clinical Faculty at Stanford from
2006-2016, where he cared for melanoma patients. At Genentech from 2006-2018, Dr
Chen focused on the clinical development of anti-angiogenic and immune
modulatory targeted therapies in both early and late Development, as well as the
diagnostic tools to aid their development. This included leading the clinical
development for atezolizumab, a PD-L1 inhibitor, from the time the program was
in research through IND, Phase I, Phase II, Phase III, to filing and approvals
in multiple indications worldwide. At IGM Biosciences, Dr Chen focused on the
development of novel engineered multivalent and multispecific therapeutics and
helped lead this from preclinical to having multiple therapeutics in the clinic
in Phase I/II. He is a reviewer for Nature, Immunity, Journal for Immunotherapy
of Cancer and Clinical Cancer Research, served on the Board of Directors for
SITC, has been a recurring session organizer and session chair for PEGS Europe
on engineered therapeutics since 2019, gave the keynote presentation at the AACR
NCI EORTC Annual Meeting 2014 and presented at the US Congressional Briefing on
Immuno Oncology in 2017. He has continued to publish with academic and industry
collaborators in the field of cancer immunotherapy, including the
often-referenced Chen and Mellman manuscripts, “Oncology meets Immunology: the
Cancer-Immunity Cycle,” “Elements of cancer immunity and the cancer-immune set
point” and the Hegde and Chen manuscript “Top 10 Challenges in Cancer
Immunotherapy.”


CARL JUNE, MD

Richard W. Vague Professor in Immunotherapy in the Department of Pathology and
Laboratory Medicine

University of Pennsylvania


CARL JUNE, MD

Richard W. Vague Professor in Immunotherapy in the Department of Pathology and
Laboratory Medicine
University of Pennsylvania

Carl June, MD, is the Richard W. Vague Professor in Immunotherapy in the
Department of Pathology and Laboratory Medicine. He is currently director of the
Center for Cellular Immunotherapies and director of Translational Research in
the Abramson Cancer Center of the University of Pennsylvania, and is an
investigator of the Abramson Family Cancer Research Institute. He is a graduate
of the Naval Academy in Annapolis and Baylor College of Medicine in Houston,
1979. He had graduate training in immunology and malaria with Dr. Paul-Henri
Lambert at the World Health Organization, Geneva, Switzerland in 1978 and 1979,
and post-doctoral training in transplantation biology with E. Donnell Thomas and
John Hansen at the Fred Hutchinson Cancer Research Center in Seattle from 1983
to 1986. He is board certified in Internal Medicine and Medical Oncology.He
maintains a research laboratory that studies various mechanisms of lymphocyte
activation that relate to immune tolerance and adoptive immunotherapy for cancer
and chronic infection. In 2011, his research team published findings, which
represented the first successful and sustained demonstration of the use of gene
transfer therapy to treat cancer. Clinical trials utilizing this approach, in
which patients are treated with genetically engineered versions of their own
T-cells, are now underway for adults with chronic lymphocytic leukemia and
adults and children with acute lymphoblastic leukemia. Early results in that
group show that 90 percent of patients respond to the therapy, and more
recently, trials of this approach have begun for patients with other blood
cancers and solid tumors including pancreatic cancer, mesothelioma and the brain
cancer glioblastoma. In 2014, it became the first personalized cellular therapy
for the treatment of cancer therapy to receive the U.S. Food and Drug
Administration’s prestigious Breakthrough Therapy designation.He has published
more than 350 manuscripts and is the recipient of numerous prizes and honors,
including election to the Institute of Medicine in 2012, the William B. Coley
award, the Richard V. Smalley Memorial Award from the Society for Immunotherapy
of Cancer, the AACR-CRI Lloyd J. Old Award in Cancer Immunology, the Hamdan
Award for Medical Research Excellence and the Paul Ehrlich and Ludwig
Darmstaedter Prize. In 2014, he was elected to the American Academy of Arts and
Sciences.
Register Now

Registration is complimentary and required to attend.

FEATURED VIDEOS & WEBCASTS

--------------------------------------------------------------------------------

 * Fireside Chat: The Future of CAR-T, Cell Therapy, T-Cell Engagers and
   Synthetic Immunity
 * Post-DPHARM: Innovative Sources & Solutions Webcast
 * Conference Forum Announces New Website!
 * John Maraganore's Reflections on Alnylam and Conquering Delivery
 * WLIB: Understanding Your Biotech Employment Contract

UPCOMING CONFERENCES

--------------------------------------------------------------------------------

 * Immuno-Oncology 360º
 * PODD: Partnership Opportunities in Drug Delivery
 * DPHARM: Disruptive Innovations to Modernize Clinical Trials
 * CRAACO: Clinical Research as a Care Option
 * Mobile Tech in Clinical Trials
 * Patients as Partners Europe

FEATURED EDITORIAL

--------------------------------------------------------------------------------

 * Directing AstraZeneca's Oncology Strategies
 * MGH Cancer Center Breaks Down the T Cell to Better Understand Immuno-Oncology
 * How the NYU Genome Center is Making Better Cell Therapies
 * Finding Career Fulfillment Working in Immune Diagnostics
   Sponsored
 * UPenn's Dr Bruce Levine on Advancements in Cell Therapy Manufacturing

FEATURED PODCASTS

--------------------------------------------------------------------------------

 * HLA Loss and the Impact on Immunotherapy
 * Innovative CRISPR Editing to Create Off-the-Shelf Immune Cell Therapies
 * Investment and Collaboration Strategies in Cell and Gene Therapy
 * Finding a Life-Saving Nivolumab Trial After a Hodgkin's Lymphoma Diagnosis
 * Targeting TGF Beta in IO: Mechanisms, Challenges and Opportunities


UPCOMING VIDEOS & WEBCASTS

View all upcoming Videos & Webcasts


FIRESIDE CHAT: THE FUTURE OF CAR-T, CELL THERAPY, T-CELL ENGAGERS AND SYNTHETIC
IMMUNITY


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