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PIONEERING INVESTIGATIVE TOXICOLOGY FOR SAFER, FASTER DRUG DEVELOPMENT

Inotiv's investigative toxicology expertise drives safe, effective therapies.
Our advanced tools minimize development risks, maximize regulatory success, and
accelerate time to market.
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IMMUNODEFICIENT MOUSE MODELS TO SUPPORT PROLONGED ENGRAFTMENT OF HUMAN NK AND
TUMOR CELLS

Explore how the B-NDG mouse model supports prolonged engraftment of human cells
for research. Learn about its immunodeficient features and applications in tumor
and stem cell studies. Watch the webinar now!
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TEKLAD TEK TALK WESTERN DIET VIDEO

The Western diet is known for developing phenotypes such as hepatic ballooning,
steatosis, increased focal lobular inflammation, and increased chemokines.
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DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY AND PATHOLOGY

Learn how to evaluate drug effects on fertility and reproduction in a webinar by
Inotiv. Discover how pathology findings inform DART and JAS for improved drug
evaluation.
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WEBINAR—SOD1G93A RAT MODEL OF ALS

Discover how the SOD1G93A rat aids ALS drug discovery. Learn about its
development, motor phenotypes, and biomarkers in this webinar from Inotiv and
Taconic.
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PROPHYLACTIC AND THERAPEUTIC BETA-HYDROXYBUTYRATE IMPROVED MOTOR DYSFUNCTION AND
CORTICAL DAMAGE IN A MOUSE MODEL OF TRAUMATIC BRAIN INJURY

Prophylactic and Therapeutic Beta-Hydroxybutyrate Improved Motor Dysfunction and
Cortical Damage in a Mouse Model of Traumatic Brain Injury
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A TRANSGENIC RAT EXPRESSING THE SOD1-G93A MUTATION EXHIBITS ALS-LIKE PHENOTYPES,
RENDERING IT AN EFFECTIVE TRANSLATIONAL MODEL FOR DRUG DEVELOPMENT

Discover how a transgenic rat model expressing the SOD1-G93A mutation mirrors
ALS-like symptoms, making it a valuable tool for drug development research.
Explore the poster for insights on disease phenotypes and study design.
Scientific Poster
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MULTIDISCIPLINARY APPROACHES OPTIMIZE CONTRACT DRUG DISCOVERY

Tired of siloed drug development? Inotiv integrates pharmacology, toxicology,
and pathology for a more efficient and cost-effective process. We help you
understand your drug's mechanism of action & potential risks early on.
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ENHANCED DETECTION SENSITIVITY IN NONCLINICAL CARDIOVASCULAR TELEMETRY STUDIES:
IMPACT OF A CHARACTERIZED FACILITY

Enhanced Detection Sensitivity in Nonclinical Cardiovascular Telemetry Studies:
Impact of a Characterized Facility
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ASSESSMENT OF FACTORS IMPACTING DUPLEXSEQ LIBRARY PERFORMANCE

Assessment of Factors Impacting DuplexSeq Library Performance
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USING HIGH-RESOLUTION MASS SPECTROMETRY AND SOFTWARE AIDED METABOLITE ASSESSMENT
FOR CYTOCHROME P450 REACTION PHENOTYPING OF LOW CLEARANCE SMALL MOLECULE DRUGS

Using High-Resolution Mass Spectrometry and Software Aided Metabolite Assessment
for Cytochrome P450 Reaction Phenotyping of Low Clearance Small Molecule Drugs
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THINKING BEYOND CYTOCHROME P450 INACTIVATION KINETICS ENHANCED UNDERSTANDING OF
THE MECHANISM OF TUCATINIB INTERACTION WITH CYP3A4

Tucatinib is effective against HER2+ breast cancer, including brain metastases.
In vitro studies identified time-dependent inhibition of CYP3A4 by tucatinib,
though with low inactivation efficiency. Poster highlights mechanism.
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