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EXPLORE


Weight Loss Treatments

THROUGH HERS

Find your custom medication kitIdentify your eating patternLearn evidence-based
skillsGet a free weight loss assessment

MEDICATIONS

GLP-1 injectionsRXNEWBupropionRXMetforminRXTopiramateRXNaltrexoneRX

GET STARTED

Start your free weight loss assessment


EXPLORE


Anxiety

Depression

All Medication

GET SUPPORT FOR

Stress & BurnoutTrouble FocusingGeneral worryDifficulty sleeping

MEDICATIONS

Generic for Lexapro®RXPopular
Escitalopram
Generic for Wellbutrin XL®RXPopular
Bupropion XL
Generic for Zoloft®RX
Sertraline
Generic for Prozac®RX
Fluoxetine
Generic for Effexor®RX
Venlafaxine
Generic for Buspar®RX
Buspirone
See all Medication

PERFORMANCE ANXIETY

PropranololRX

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Get personalized support for your mental health


THICKER, FULLER HAIR THIS WAY


About Hers Hair

Hair loss treatments

Hair BlendsRXNEW

TYPES OF HAIR THINNING

Overall thinningStress related thinningAging and hormonesMenopausal

CUSTOM HAIR BLENDS

Hair Vitamins + MinoxidilRXNEWBiotin + MinoxidilRXNEWPostmenopausal Hair Loss
SprayRX

GENERIC OPTIONS

Oral MinoxidilRXMinoxidil SolutionMinoxidil FoamLatisse®RX
for Lashes

HAIR CARE KITS

Triple Threat shampoo & conditionerFull Volume shampoo & conditioner

STRENGTHENING HAIR CARE

Biotin Builder GummiesTriple Threat ShampooTriple Threat Conditioner Full Volume
ShampooNEWFull Volume ConditionerNEW

GET STARTED

Take the free hair quiz


EXPLORE


Supplements

Sex

PLEASURE

Omg RingRoller CoasterGlide aloe veraLuxe condoms and lube

SEXUAL HEALTH

Birth control pillsRXDesire libido gummiesSee all

SKIN

Triple Plump Hyaluronic SerumNEWAnti-agingAcneSkincare essentialsSee all

SUPPLEMENTS

Desire libido pillsDesire libido gummiesDetox gut healthSee all



PRESCRIPTION WEIGHT LOSS THAT PUTS YOU FIRST

Personalized, doctor-trusted treatment plans



GLP-1s and medication kits tailored to your unique needs



Ongoing care and check-ins included, 100% online

Get started
See if treatment is right for me

Prescription products require an online consultation with a healthcare provider
who will determine if a prescription is appropriate.




PRESCRIPTION INGREDIENTS
FOR PERSONALIZED CARE

Get access to treatment options like custom medication kits and GLP-1s, if a
provider determines they’re right for you.

Start your free assessment

GLP-1 INJECTIONS

New

Doctor-trusted options, injected weekly and starting at $199/mo

See if GLP-1s are right for me

COMPOUNDED SEMAGLUTIDE

In stock

Starting at $199/mo

Important safety information

OZEMPIC®

Out of stock

Starting at $1,899/mo

Important safety information

WEGOVY®

Out of stock

Starting at $2,599/mo

Important safety information


A healthcare provider may prescribe a compounded drug if determined that it is
medically appropriate and necessary for you. Compounded semaglutide is not
approved nor evaluated for safety, efficacy, or quality by FDA. Wegovy® is
FDA-approved for weight loss. Ozempic® is FDA-approved for type 2 diabetes
treatment but may be prescribed off-label for weight loss at a healthcare
provider's discretion. GLP-1 results are contingent upon a reduced-calorie meal
plan and increased physical activity. Cessation of GLP-1s has been found to
result in weight gain.

MEDICATION KITS

Custom oral medication kits, taken daily and starting at just $79/mo

Find my medication kit

BUPROPION

Important safety information

METFORMIN

Important safety information

TOPIRAMATE

Important safety information

VITAMIN B12

Cyanocobalamin

Important safety information

NALTREXONE

Important safety information

Start your free assessment

Hers Weight Loss custom medication kits are prescribed based on what your
provider determines is medically appropriate and necessary for you. This may
include prescribing generic drug products, and/or compounded products if
appropriate and necessary. Compounded drug products are not approved nor
evaluated for safety, efficacy, or quality by FDA.





A MIND-BODY BALANCE

These personalized plans are based on your lifestyle, eating pattern, health
history, and weight loss goals.

Get started

MEDICATION TO
REDUCE APPETITE

REALISTIC
NUTRITION PRINCIPLES

TIPS TAILORED TO YOUR
EATING PROFILE

SUPPORT FOR
BETTER SLEEP

CUSTOM IN-APP TOOLS
AND TRACKING

MADE TO FIT
YOUR LIFESTYLE

DESIGNED BY
SPECIALISTS

PLANS STARTING
AT $79/MONTH

MEDICATION TO
REDUCE APPETITE

REALISTIC
NUTRITION PRINCIPLES

TIPS TAILORED TO YOUR
EATING PROFILE

SUPPORT FOR
BETTER SLEEP

CUSTOM IN-APP TOOLS
AND TRACKING

MADE TO FIT
YOUR LIFESTYLE

DESIGNED BY
SPECIALISTS

PLANS STARTING
AT $79/MONTH

Get started



HERS CAN HELP


BREAK THE CYCLE



Instead of treating the surface level ups and downs of weight loss, our plans go
deeper to address the underlying factors affecting you.


FEEL LIKE YOURSELF



Get your confidence back with treatment that’s made for you and made to help you
feel like you.


LIVE YOUR LIFE



Say yes with no stress and keep up with your kids, friends, and family.


IMPROVE YOUR HEALTH



If you’re at risk for certain medical conditions or concerns, healthy weight
loss can help.

Find my treatment



WHY WOMEN CHOOSE HERS

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TRUSTED
MEDICATIONS

GLP-1s and medication kits tailored to your unique goals, so you have all the
support you need to feel your best

ACCESS TO
THE EXPERTS

Programs developed with industry specialists who have decades of experience with
weight loss

FOCUSED ON
ALL OF YOU

Holistic care including nutritional principles, behavioral programs, and custom
lessons in the Hers app

ONGOING
SUPPORT

Check-ins, medication adjustments, and answers to questions—100% online and at
no additional cost


Get started


FREQUENTLY ASKED QUESTIONS

See if you qualify


WHAT ARE MY WEIGHT LOSS TREATMENT OPTIONS THROUGH HERS?



Hers offers customized weight loss plans designed to meet your unique weight
loss goals. Your provider may recommend a combination of medications, such as
GLP-1 injections and oral medication kits.

We also offer evidence-based content, tips and tricks, and convenient recipes
that will help you achieve the results you’re looking for.

Get started now


DO YOU PRESCRIBE GLP-1S?



Hers offers access to compounded semaglutide (a compounded GLP-1) as well as
name brand options like Ozempic® and Wegovy®, which are all injected weekly, if
prescribed by a licensed provider.

Get started now


WHAT OTHER MEDICATIONS DO YOU OFFER?



Hers also offers personalized medication kits that can include a combination of
metformin, bupropion, topiramate, vitamin B12, and naltrexone. Taken as a once
or twice daily pill, these medications work together to support your weight loss
goals.

Your provider will help you find the right medication based on your medication
history and custom weight loss profile.

Get started now


HOW MUCH DO COMPOUNDED GLP-1S COST AT HERS?



Pricing for our compounded GLP-1 injections start at $199/month. Total pricing
varies at checkout.

Get started now


HOW DO I GET STARTED WITH MY WEIGHT LOSS TREATMENT?



You’ll begin by answering questions about your medical history and weight loss
goals to create your custom profile. A licensed provider will then review your
information 100% online to determine if treatment is right for you. If
prescribed, you’ll receive a message from a provider with information about your
personalized plan.

Get started now


ARE VIDEO VISITS WITH A DOCTOR REQUIRED?



No video visit is required; a provider will review your information 100% online.
If prescribed, you’ll get unlimited online access to message your provider as
needed for follow-ups, adjustments, and answers to your questions.

Get started now


IS INSURANCE REQUIRED?



No, Hers does not require insurance. We have a straight-forward approach to
pricing and billing, as well as affordable generic options to make taking care
of yourself as simple as possible.

Get started now


CAN I PAY WITH AN FSA OR HSA?



Hers does not take FSA or HSA as payment at this time.

Get started now


WHAT IS COMPOUNDED SEMAGLUTIDE?



Working with a licensed compounding pharmacy, Hers is able to provide
medications to meet our patients’ unique needs. Hers offers compounded
semaglutide, a GLP-1 injection with the same active ingredient as Wegovy® and
Ozempic®.

This differs from brand-name weight loss injections, which typically come in a
preloaded injection pen. But don’t worry, Hers will show you exactly how to take
your injection, and you’ll have access to unlimited messaging.

Get started now


HOW MUCH WEIGHT CAN I LOSE WITH WEIGHT LOSS MEDICATIONS?



As a science-backed weight loss program that’s been developed by experts, your
unique treatment plan is designed to support healthy, sustainable results.

Studies show that GLP-1 injections can result in about 1 in 3 adults achieving
20% weight loss*

Because everyone’s weight loss journey is different, the timeline for results
may vary from person to person.

In general, it’s important to:

 * Take your medication as directed
 * Support your progress with healthy nutrition
 * Incorporate consistent, moderate exercise into your routine

*Results are contingent upon a reduced-calorie meal plan and increased physical
activity. Individual results may vary. Please consult with health care provider
to determine eligibility and discuss a goal weight that is healthy and realistic
for you. Cessation of semaglutide treatment has been found to result in weight
gain.

Source. According to a 68-week placebo-controlled study of 1,961 obese and
overweight non-diabetic adults with weight related medical problem conditions,
30% of the treatment group lost 20% or more weight compared to 2% of the placebo
group. Both groups were prescribed a reduced-calorie diet, increased physical
activity, and monthly nutritional counseling. Starting semaglutide (Wegovy)
dosage was 0.25mg per week and increased up to 2.4mg. The trial was overseen,
designed, and sponsored by Novo Nordisk.

Get started now


HOW IS HERS DEALING WITH GLP-1 SHORTAGES?



Hers is working closely with trusted partners to support our customers in
accessing the weight loss treatment that is right for them.

While name-brand medications like Ozempic® and Wegovy® are currently in short
supply, Hers also provides compounded GLP-1s formulated with the same active
ingredient. This means you can start your weight loss journey with confidence.

Get started now


WHO QUALIFIES FOR COMPOUNDED GLP-1S AT HERS?



A provider will review your health history, weight loss goals, as well as your
BMI to see if you qualify for treatment.

Get started now


ARE GLP-1S AVAILABLE IN ALL STATES?



Unfortunately, GLP-1s are not yet available in all 50 states; however, Hers is
working to expand our offering as soon as possible.

Get started now
See if you qualify



HEAR IT FROM HER

Kristie B.



“I LOVE BEING ABLE TO TRACK MY MEDICATIONS, MOVEMENT, DIET, SLEEP, AND WATER
INTAKE ALL IN ONE PLACE. IT’S TAKING MY PERSONAL HEALTH TO A BETTER PLACE AND I
HAVE A GOOD WEIGHT LOSS PLAN THAT I CAN CONTINUE TO FOLLOW.”

Real Hers customer

Courtney B.

 

“THEY TOOK THE TIME TO UNDERSTAND MY PERSONAL EXPERIENCE, HABITS, TRIGGERS, AND
HEALTH HISTORY BEFORE DETERMINING WHICH COMBINATION OF MEDICATIONS WAS RIGHT FOR
ME.”

Real Hers customer

Misty K.



“THE APP MAKES THE MEDICATION INFORMATION EASY TO UNDERSTAND. MY EXPERIENCE WITH
HERS HAS BEEN WONDERFUL AND IT'S GREAT KNOWING THERE ACTUALLY IS A SOLUTION TO
MY PROBLEM."

Real Hers customer

Lola M.

 

“IT WAS SO SIMPLE TO SIGN UP—ANSWER A FEW QUESTIONS AND THEN YOU GET A RESPONSE
REALLY QUICKLY AND BEFORE YOU KNOW IT, YOUR MEDS ARE ON THE WAY! BEST THING I
HAVE DONE FOR MYSELF IN A LONG TIME!"

Real Hers customer

Jessica B.



“I LOOKED INTO OTHER PROGRAMS AND THE COST WAS MONTHLY WHAT HERS WAS FOR 6
MONTHS. I WAS SOLD! SIGN UP AND CONSULTATION WERE SO SIMPLE AND I RECEIVED MY
SHIPMENT WITHIN A WEEK.”

Real Hers customer

 

 

READY TO BEGIN YOUR WEIGHT LOSS JOURNEY?

Get started today


See if treatment is right for me

Medications are part of the Hers Weight Loss program, which also includes a
reduced calorie diet and increased physical activity. Customer was compensated
for their opinion. Results shared by customers who have purchased varying
products, including prescription based products. Customer's results have not
been independently verified. Individual results will vary.





HOW IT WORKS

Get started today

Medical intake

Answer some questions about your health history, lifestyle, and goals,
100% online.

Provider evaluation

A medical professional will review your intake and determine what’s right
for you.

Personalized plan

If prescribed, you’ll get a customized holistic plan designed to work for you.

Ongoing support

Get unlimited online access to follow-ups, adjustments, and answers to
questions.

Get started today



DESIGNED BY DOCTORS,
SHAPED BY YOU

Free assessment by a medical professional through Hers



No in-person visit or insurance required



Personalized to your unique needs

Get started

1 & 2. Source. In a placebo-controlled study of fifteen normal weight adult men,
metformin reduced hunger induced by hypoglycemia, a major short-term regulator
of hunger.

3. In a meta-analysis of 21 studies, participants prescribed metformin saw a BMI
reduction

4. Placebo-controlled study of 3,234 participants, who were prescribed a
lifestyle intervention, placebo, or 1,700 mg/day of metformin.

Go back


5. Based on a 6-month placebo-controlled study of 1,289 adults with obesity. All
participants also participated in a weight-loss program

6. Compared to placebo group which lost only 1.7%. Participants were prescribed
96 mg/day of topiramate. All 1,289 participants also participated in a weight
loss program

7. Source. Topiramate acts on both GABA-A and glutamate receptors in the brain,
which augment appetite suppression and satiety enhancement

Go back


8. Source. Based on a placebo-controlled study of 390 adults with type 2
diabetes showing that long-term metformin use significantly reduced B12 levels.
Source. A B12 supplement (1 to 2 mg/day) can help protect against the effects of
vitamin B12 deficiency.

Go back


9. Based on a 56-week placebo controlled study of Naltrexone and Bupropion in
combination

10. Compared to 15% of placebo group. Daily dosage of bupropion ranged between
200 and 400 mg. All 50 participants were prescribed a 1,600 kcal/day balanced
diet

Go back


Important Safety Information

NALTREXONE + VITAMIN B12 is a compounded product and is not FDA-approved. The
FDA does not verify the safety or effectiveness of compounded drugs
NALTREXONE is a prescription medication that is FDA approved to: treat alcohol
dependence prevent relapse to opioid dependence, after opioid detoxification.
VITAMIN B12 is a dietary supplement utilized in many areas of the body
principally for the proper function of your red blood cells, nerve cells, energy
levels and mood. Additionally it is used to supplement B12 when other drugs may
possibly decrease its level.
NALTREXONE + VITAMIN B12 is a prescription medicine that is prescribed off-label
and may help some adults with overweight and obesity lose weight and keep the
weight off.
IMPORTANT SAFETY INFORMATION NALTREXONE + VITAMIN B12 can cause serious side
effects, including:
 * Risk of opioid overdose. You can accidentally overdose in two ways.
   * NALTREXONE + VITAMIN B12 blocks the effects of opioids, such as heroin or
     opioid pain medicines, examples include, but are not limited to; morphine
     (MS Contin), hydrocodone (Vicodin), oxycodone (Oxycontin), hydromorphone
     (Percocet), codeine, or tramadol. Do not try to overcome this blocking
     effect by taking large amounts of opioids—this can lead to serious injury,
     coma, or death.
   * After you receive a dose of NALTREXONE + VITAMIN B12, its blocking effect
     slowly decreases and completely goes away over time. If you have used
     opioid street drugs or opioid-containing medicines in the past, using
     opioids in amounts that you used before treatment with NALTREXONE + VITAMIN
     B12 can lead to overdose and death. You may also be more sensitive to the
     effects of lower amounts of opioids:
     * after you have gone through detoxification
     * when your next NALTREXONE + VITAMIN B12 dose is due
     * if you miss a dose of NALTREXONE + VITAMIN B12
     * after you stop NALTREXONE + VITAMIN B12 treatment
 * Tell your family and the people closest to you of this increased sensitivity
   to opioids and the risk of overdose.

Talk to your healthcare provider about naloxone, a medicine that is available to
patients for the emergency treatment of an opioid overdose. Call 911 or get
emergency medical help right away in all cases of known or suspected opioid
overdose, even if naloxone is administered.
 * Sudden opioid withdrawal. To avoid sudden opioid withdrawal, you must stop
   taking any type of opioid, including street drugs; prescription pain
   medicines; cough, cold, or diarrhea medicines that contain opioids; or
   opioid-dependence treatments, including buprenorphine or methadone, for at
   least 7 to 14 days before starting NALTREXONE + VITAMIN B12. Sudden opioid
   withdrawal can be severe and may require hospitalization.
 * Liver damage or hepatitis. NALTREXONE + VITAMIN B12 can cause liver damage or
   hepatitis. Tell your healthcare provider if you have any of these symptoms
   during treatment with NALTREXONE + VITAMIN B12:
   * stomach area pain lasting more than a few days
   * dark urine
   * yellowing of the whites of your eyes
   * tiredness
 * Your healthcare provider may need to stop treating you with NALTREXONE +
   VITAMIN B12 if you get signs or symptoms of a serious liver problem.

You must stop taking opioids before you start taking NALTREXONE + VITAMIN B12.
It is not known if NALTREXONE + VITAMIN B12 is safe and effective in children.
Who should not take NALTREXONE + VITAMIN B12?
Do not take NALTREXONE + VITAMIN B12 if you:
 * are using or have a physical dependence on opioid-containing medicines, such
   as but not limited to, morphine (MS Contin), hydrocodone (Vicodin), oxycodone
   (Oxycontin), hydromorphone (Percocet), codeine, or tramadol. or opioid street
   drugs, such as heroin.
 * are having opioid withdrawal symptoms. Opioid withdrawal symptoms may happen
   when you have been taking opioid containing medicines or opioid street drugs
   regularly and then stop. Symptoms of opioid withdrawal may include: anxiety,
   sleeplessness, yawning, fever, sweating, teary eyes, runny nose, goosebumps,
   shakiness, hot or cold flushes, muscle aches, muscle twitches, restlessness,
   nausea and vomiting, diarrhea, or stomach cramps.
 * are allergic to NALTREXONE + VITAMIN B12 or any of the inactive ingredients
   in NALTREXONE + VITAMIN B12. See the medication guide for the full list of
   ingredients.

What should I tell my healthcare provider before taking NALTREXONE + VITAMIN
B12? Before you take NALTREXONE + VITAMIN B12, tell your healthcare provider if
you:
 * have liver problems, use or abuse street (illegal) drugs, have hemophilia or
   other bleeding problems, have kidney problems, or have any other medical
   conditions.
 * are pregnant or plan to become pregnant. It is not known if NALTREXONE +
   VITAMIN B12 will harm your unborn baby. are breastfeeding. NALTREXONE +
   VITAMIN B12 passes into breast milk. Talk - to your healthcare provider about
   whether you will breastfeed or take NALTREXONE + VITAMIN B12. You should not
   do both.

Tell your healthcare provider about all the medicines you take, including
prescription and non-prescription medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you take any opioid-containing
medicines for pain, cough or colds, or diarrhea.
What are other possible serious side effects of NALTREXONE + VITAMIN B12?
NALTREXONE + VITAMIN B12 can cause serious side effects, including:
Depressed mood. Sometimes this leads to suicide, or suicidal thoughts, and
suicidal behavior. Tell your family members and people closest to you that you
are taking NALTREXONE + VITAMIN B12.
Pneumonia. Some people receiving NALTREXONE + VITAMIN B12 treatment have had a
type of pneumonia that is caused by an allergic reaction. If this happens to
you, you may need to be treated in the hospital.
Serious allergic reactions. Serious allergic reactions can happen during or soon
after an injection of NALTREXONE + VITAMIN B12. Tell your healthcare provider or
get medical help right away if you have any of these symptoms:
 * skin rash
 * swelling of your face, eyes, mouth, or tongue
 * trouble breathing or wheezing
 * chest pain
 * feeling dizzy or faint

Common side effects of NALTREXONE + VITAMIN B12 may include:
 * nausea
 * sleepiness
 * headache
 * dizziness
 * vomiting
 * decreased appetite
 * painful joints
 * muscle cramps
 * cold symptoms
 * trouble sleeping
 * toothache

These are not all the side effects of NALTREXONE + VITAMIN B12. Tell your
healthcare provider if you have any side effect that bothers you or that does
not go away. You are encouraged to report all side effects to the FDA. Visit
www.fda.gov/medwatch, or call 1-800-FDA-1088. This is only a summary of the most
important information about NALTREXONE + VITAMIN B12.
Need more information? Ask your healthcare provider or pharmacist.


Important Safety Information

TOPIRAMATE + VITAMIN B12 is a compounded product and is not FDA-approved. The
FDA does not verify the safety or effectiveness of compounded drugs.
TOPIRAMATE (Topamax®) is FDA approved to:
 * to treat certain types of seizures (partial-onset seizures and primary
   generalized tonic-clonic seizures) in adults and children 2 years and older,
 * with other medicines to treat certain types of seizures (partial-onset
   seizures, primary generalized tonic-clonic seizures, and seizures associated
   with Lennox-Gastaut syndrome) in adults and children 2 years and older,
 * to prevent migraine headaches in adults and adolescents 12 years and older.

VITAMIN B12 is a dietary supplement utilized in many areas of the body
principally for the proper function of your red blood cells, nerve cells, energy
levels and mood. Additionally it is used to supplement B12 when other drugs may
possibly decrease its level.
TOPIRAMATE + VITAMIN B12 is prescribed off-label and may help some adults with
overweight and obesity lose weight and keep the weight off.
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about TOPIRAMATE + VITAMIN
B12?
TOPIRAMATE + VITAMIN B12 may cause eye problems. Serious eye problems include:
 * Any sudden decrease in vision with or without eye pain and redness.
 * A blockage of fluid in the eye causing increased pressure in the eye
   (secondary angle closure glaucoma).

These eye problems can lead to permanent loss of vision if not treated.
You should call your healthcare provider right away if you have any new eye
symptoms, including any new problems with your vision.
TOPIRAMATE + VITAMIN B12 may cause decreased sweating and increased body
temperature (fever). People, especially children, should be watched for signs of
decreased sweating and fever, especially in hot temperatures. Some people may
need to be hospitalized for this condition. If a high fever, a fever that does
not go away, or decreased sweating develops, call your healthcare provider right
away.
TOPIRAMATE + VITAMIN B12 can increase the level of acid in your blood (metabolic
acidosis). If left untreated, metabolic acidosis can cause brittle or soft bones
(osteoporosis, osteomalacia, osteopenia), kidney stones, can slow the rate of
growth in children, and may possibly harm your baby if you are pregnant.
Metabolic acidosis can happen with or without symptoms. Sometimes people with
metabolic acidosis will:
 * Feel tired
 * Not feel hungry (loss of appetite)
 * Feel changes in heartbeat
 * Have trouble thinking clearly

Your healthcare provider should do a blood test to measure the level of acid in
your blood before and during your treatment with TOPIRAMATE + VITAMIN B12. If
you are pregnant, you should talk to your healthcare provider about whether you
have metabolic acidosis.
Like other antiepileptic drugs, TOPIRAMATE + VITAMIN B12 may cause suicidal
thoughts or actions in a very small number of people, about 1 in 500. Call a
healthcare provider right away if you have any of these symptoms, especially if
they are new, worse, or worry you:

• Thoughts about suicide or dying• Feeling agitated or restless• Attempts to
commit suicide• Trouble sleeping (insomnia)• New or worse depression• New or
worse irritability• New or worse anxiety• Acting aggressive, being angry or
violent• Panic attacks• Acting on dangerous impulses• An extreme increase in
activity and talking (mania)• Other unusual changes in behavior or mood

TOPIRAMATE + VITAMIN B12 may lower bone mineral density. TOPIRAMATE + VITAMIN
B12 may decrease the density of bones when used over a long period.
TOPIRAMATE + VITAMIN B12 may have negative effects on growth in children
TOPIRAMATE + VITAMIN B12 may slow height increases and weight gain in children
and adolescents when used over a long period
Do not stop TOPIRAMATE + VITAMIN B12 without first talking to a healthcare
provider.
 * Stopping TOPIRAMATE + VITAMIN B12 suddenly can cause serious problems.
 * Suicidal thoughts or actions can be caused by things other than medicines. If
   you have suicidal thoughts or actions, your healthcare provider may check for
   other causes.
 * If you have epilepsy and you stop taking TOPIRAMATE + VITAMIN B12 suddenly,
   you may have seizures that do not stop. Your healthcare provider will tell
   you how to stop taking TOPIRAMATE + VITAMIN B12 slowly.
 * If you miss a single dose of TOPIRAMATE + VITAMIN B12, take it as soon as you
   can. However, if you are within 6 hours of taking your next scheduled dose,
   wait until then to take your usual dose of TOPIRAMATE + VITAMIN B12 and skip
   the missed dose. Do not double your dose. If you have missed more than one
   dose, you should call your healthcare provider for advice.

How can I watch for early symptoms of suicidal thoughts and actions?
 * Pay attention to any changes, especially sudden changes, in mood, behaviors,
   thoughts, or feelings.
 * Keep all follow-up visits with your healthcare provider as scheduled.
 * Call your healthcare provider between visits as needed, especially if you are
   worried about symptoms.

TOPIRAMATE + VITAMIN B12 can harm your unborn baby.
 * If you take TOPIRAMATE + VITAMIN B12 during pregnancy, your baby has a higher
   risk for birth defects called cleft lip and cleft palate. These defects can
   begin early in pregnancy, even before you know you are pregnant.
 * Cleft lip and cleft palate may happen even in children born to women who are
   not taking any medicines and do not have other risk factors.
 * There may be other medicines to treat your condition that have a lower chance
   of birth defects.
 * All women of childbearing age should talk to their healthcare providers about
   using other possible treatments instead of TOPIRAMATE + VITAMIN B12. If the
   decision is made to use TOPIRAMATE + VITAMIN B12, you should use effective
   birth control (contraception) unless you are planning to become pregnant. You
   should talk to your doctor about the best kind of birth control to use while
   you are taking TOPIRAMATE + VITAMIN B12.
 * Tell your healthcare provider right away if you become pregnant while taking
   TOPIRAMATE + VITAMIN B12. You and your healthcare provider should decide if
   you will continue to take TOPIRAMATE + VITAMIN B12 while you are pregnant.
 * If you take TOPIRAMATE + VITAMIN B12 during pregnancy, your baby may be
   smaller than expected at birth. The long-term effects of this are not known.
   Talk to your healthcare provider if you have questions about this risk during
   pregnancy.
 * Metabolic acidosis may have harmful effects on your baby. Talk to your
   healthcare provider if TOPIRAMATE + VITAMIN B12 has caused metabolic acidosis
   during your pregnancy.
 * Pregnancy Registry: If you become pregnant while taking TOPIRAMATE + VITAMIN
   B12, talk to your healthcare provider about registering with the North
   American Antiepileptic Drug Pregnancy Registry. You can enroll in this
   registry by calling 1-888-233-2334. The purpose of this registry is to
   collect information about the safety of TOPIRAMATE + VITAMIN B12 and other
   antiepileptic drugs during pregnancy.

Before taking TOPIRAMATE + VITAMIN B12, tell your healthcare provider about all
of your medical conditions, including if you:
 * Have or have had depression, mood problems, or suicidal thoughts or behavior
 * Have kidney problems, have kidney stones, or are getting kidney dialysis
 * Have a history of metabolic acidosis (too much acid in the blood)
 * Have liver problems
 * Have weak, brittle, or soft bones (osteomalacia, osteoporosis, osteopenia, or
   decreased bone density)
 * Have lung or breathing problems
 * Have eye problems, especially glaucoma
 * Have diarrhea
 * Have a growth problem
 * Are on a diet high in fat and low in carbohydrates, which is called a
   ketogenic diet
 * Are having surgery
 * Are pregnant or plan to become pregnant
 * Are breastfeeding or plan to breastfeed? TOPIRAMATE + VITAMIN B12 passes into
   breast milk. Breastfed babies may be sleepy or have diarrhea. It is not known
   if the TOPIRAMATE + VITAMIN B12 that passes into breast milk can cause
   serious harm to your baby. Talk to your healthcare provider about the best
   way to feed your baby if you take TOPIRAMATE + VITAMIN B12.

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.
TOPIRAMATE + VITAMIN B12 and other medicines may affect each other causing side
effects. Especially tell your healthcare provider if you take:
 * Valproic acid (such as Depakene® or Depakote®).
 * Any medicines that impair or decrease your thinking, concentration, or muscle
   coordination.
 * Birth control that contains hormones (such as pills, implants, patches or
   injections). TOPIRAMATE + VITAMIN B12 may make your birth control less
   effective. Tell your healthcare provider if your menstrual bleeding changes
   while you are using birth control and TOPIRAMATE + VITAMIN B12.

Ask your healthcare provider if you are not sure if your medicine is listed
above. Know the medicines you take. Keep a list of them to show your healthcare
provider and pharmacist each time you get a new medicine. Do not start a new
medicine without talking with your healthcare provider.
How should I take TOPIRAMATE + VITAMIN B12?
 * Take TOPIRAMATE + VITAMIN B12 exactly as prescribed.
 * Your healthcare provider may change your dose. Do not change your dose
   without talking to your healthcare provider.
 * Take TOPIRAMATE + VITAMIN B12 tablets whole. Do not chew the tablets. They
   may leave a bitter taste.
 * TOPIRAMATE + VITAMIN B12 can be taken before, during, or after a meal. Drink
   plenty of fluids during the day. This may help prevent kidney stones while
   taking TOPIRAMATE + VITAMIN B12.
 * If you take too much TOPIRAMATE + VITAMIN B12, call your healthcare provider
   right away or go to the nearest emergency room.
 * If you miss a single dose of TOPIRAMATE + VITAMIN B12, take it as soon as you
   can. However, if you are within 6 hours of taking your next scheduled dose,
   wait until then to take your usual dose of TOPIRAMATE + VITAMIN B12 and skip
   the missed dose. Do not double your dose. If you have missed more than one
   dose, you should call your healthcare provider for advice.
 * Do not stop taking TOPIRAMATE + VITAMIN B12 without talking to your
   healthcare provider. Stopping TOPIRAMATE + VITAMIN B12 suddenly may cause
   serious problems. If you have epilepsy and you stop taking TOPIRAMATE +
   VITAMIN B12 suddenly, you may have seizures that do not stop. Your healthcare
   provider will tell you how to stop taking TOPIRAMATE + VITAMIN B12 slowly.
 * Your healthcare provider may do blood tests while you take TOPIRAMATE +
   VITAMIN B12.

What should I avoid while taking TOPIRAMATE + VITAMIN B12?
 * You should not drink alcohol while taking TOPIRAMATE + VITAMIN B12.
   TOPIRAMATE + VITAMIN B12 and alcohol can affect each other, causing side
   effects such as sleepiness and dizziness.
 * Do not drive a car or operate machinery until you know how TOPIRAMATE +
   VITAMIN B12 affects you. TOPIRAMATE + VITAMIN B12 can slow your thinking and
   motor skills, and may affect vision.

Even when taking TOPIRAMATE + VITAMIN B12 or other antiepileptic medicines, some
people with epilepsy will continue to have unpredictable seizures. Therefore,
use caution and talk to your doctor before beginning any activities where loss
of consciousness could result in serious danger to you or those around you
(including swimming, driving a car, climbing in high places, etc.).
What are the possible side effects of TOPIRAMATE + VITAMIN B12?
TOPIRAMATE + VITAMIN B12 may cause serious side effects including:
See “What is the most important information I should know about TOPIRAMATE +
VITAMIN B12?”
High blood ammonia levels. High ammonia in the blood can affect your mental
activities, slow your alertness, make you feel tired, or cause vomiting. This
has happened when TOPIRAMATE + VITAMIN B12 is taken with a medicine called
valproic acid (Depakene® or Depakote®).
Effects on thinking and alertness. TOPIRAMATE + VITAMIN B12 may affect how you
think and cause confusion, problems with concentration, attention, memory, or
speech. TOPIRAMATE + VITAMIN B12 may cause depression or mood problems,
tiredness, and sleepiness.
Dizziness or loss of muscle coordination.
Serious skin reactions. TOPIRAMATE + VITAMIN B12 may cause a severe rash with
blisters and peeling skin, especially around the mouth, nose, eyes, and genitals
(Stevens-Johnson syndrome). TOPIRAMATE + VITAMIN B12 may also cause a rash with
blisters and peeling skin over much of the body that may cause death (toxic
epidermal necrolysis). Call your healthcare provider right away if you develop a
skin rash or blisters.
Kidney stones. Drink plenty of fluids when taking TOPIRAMATE + VITAMIN B12 to
decrease your chances of getting kidney stones.
Low body temperature. Taking TOPIRAMATE + VITAMIN B12 when you are also taking
valproic acid can cause a drop in body temperature to less than 95°F, feeling
tired, confusion, or coma.
Call your healthcare provider right away if you have any of the symptoms above.
The most common side effects of TOPIRAMATE + VITAMIN B12 include:

• Tingling of the arms and legs (paresthesia)• Dizziness• Not feeling hungry•
Sleepiness/drowsiness• Nausea• Slow reactions• A change in the way foods taste•
Difficulty with memory• Diarrhea• Pain in the abdomen• Weight loss• Fever•
Nervousness• Abnormal vision• Upper respiratory tract infection• Decreased
feeling or sensitivity, especially in the skin• Speech problems• Tiredness

Tell your healthcare provider about any side effect that bothers you or that
does not go away. You are encouraged to report all side effects to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
These are not all the possible side effects of TOPAMAX


Important Safety Information

METFORMIN XR is a prescription medicine that is FDA approved to treat Type 2
diabetes mellitus when hyperglycemia cannot be managed with diet and exercise
alone.
When prescribed off-label METFORMIN XR may help some adults with overweight or
obesity lose weight and keep the weight off.
IMPORTANT SAFETY INFORMATION What is the most important information I should
know about METFORMIN XR tablets?
Lactic Acidosis. Metformin, the medicine in METFORMIN XR tablets, can cause a
rare, but serious, side effect called lactic acidosis (a build-up of lactic acid
in the blood) that can cause death. Lactic acidosis is a medical emergency and
must be treated in a hospital.
Stop taking METFORMIN XR tablets and call your healthcare provider right away if
you get any of the following symptoms of lactic acidosis:
 * feel very weak and tired
 * have unusual (not normal) muscle pain
 * have trouble breathing
 * have unusual sleepiness or sleep longer than usual
 * have unexplained stomach or intestinal problems with nausea and vomiting, or
   diarrhea
 * feel cold, especially in your arms and legs
 * feel dizzy or lightheaded
 * have a slow or irregular heartbeat

You have a higher chance of getting lactic acidosis if you:
 * have kidney problems. People whose kidneys are not working properly should
   not take METFORMIN XR tablets.
 * have liver problems.
 * have congestive heart failure that requires treatment with medicines.
 * drink a lot of alcohol (very often or short-term "binge" drinking).
 * get dehydrated (lose a large amount of body fluids). This can happen - if you
   are sick with a fever, vomiting, or diarrhea. Dehydration can also happen
   when you sweat a lot with activity or exercise and do not drink enough
   fluids.
 * have certain x-ray tests with injectable dyes or contrast agents.
 * have surgery.
 * have a heart attack, severe infection, or stroke.
 * are 80 years of age or older and have not had your kidney function tested.

Do not take METFORMIN XR tablets if you:
 * have kidney problems
 * are allergic to the metformin in METFORMIN XR tablets or any of the
   ingredients in METFORMIN XR tablets. See the medication guide for the full
   list of ingredients.
 * are going to get an injection of dye or contrast agents for an x-ray
   procedure or if you are going to have surgery and not able to eat or drink
   much. In these situations, METFORMIN XR tablets will need to be stopped for a
   short time. Talk to your healthcare provider about when you should stop
   METFORMIN XR tablets and when you should start METFORMIN XR tablets again.

What should I tell my healthcare provider before taking METFORMIN XR tablets?
Before taking METFORMIN XR tablets, tell your healthcare provider if you:
 * have type 1 diabetes. METFORMIN XR tablets should not be used to treat people
   with type 1 diabetes.
 * have a history or risk for diabetic ketoacidosis (high levels of certain
   acids, known as ketones, in the blood or urine). METFORMIN XR tablets should
   not be used for the treatment of diabetic ketoacidosis.
 * have kidney problems.
 * have liver problems.
 * have heart problems, including congestive heart failure.
 * are older than 80 years. If you are over 80 years old you should not take
   METFORMIN XR tablets unless your kidneys have been checked and they are
   normal.
 * drink alcohol very often, or drink a lot of alcohol in short-term "binge"
   drinking.
 * are taking insulin.
 * have any other medical conditions.
 * are pregnant or plan to become pregnant. It is not known if metformin will
   harm your unborn baby. If you are pregnant, talk with your healthcare
   provider about the best way to control your blood sugar while you are
   pregnant.
 * are breast-feeding or plan to breast-feed. It is not known if metformin
   passes into your breast milk. Talk with your healthcare provider about the
   best way to feed your baby while you take METFORMIN XR tablets. Tell your
   healthcare provider about all the medicines you take, including prescription
   and nonprescription medicines, vitamins, and herbal supplements. Know the
   medicines you take. Keep a list of them to show your healthcare provider and
   pharmacist when you get a new medicine.
 * METFORMIN XR tablets may affect the way other medicines work, and other
   medicines may affect how METFORMIN XR tablets work.

Common side effects of METFORMIN XR tablets include diarrhea, nausea, and upset
stomach. These side effects generally go away after you take the medicine for a
while. Taking your medicine with meals can help reduce these side effects. Tell
your healthcare provider if the side effects bother you a lot, last for more
than a few weeks, come back after they've gone away, or start later in therapy.
You may need a lower dose or need to stop taking the medicine for a short period
or for good.
About 3 out of every 100 people who take METFORMIN XR tablets have an unpleasant
metallic taste when they start taking the medicine. It lasts for a short time.
METFORMIN XR tablets rarely cause hypoglycemia (low blood sugar) by themselves.
However, hypoglycemia can happen if you do not eat enough, if you drink alcohol,
or if you take other medicines to lower blood sugar.
You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
The health information contained herein is provided for educational purposes
only and is not intended to replace discussions with a healthcare provider. All
decisions regarding patient care must be made with a healthcare provider,
considering the unique characteristics of the patient. The product information
provided is intended only for residents of the United States. The products
discussed herein may have different product labeling in different countries.


Important Safety Information

BUPROPION XL (Wellbutrin XL©) is a prescription medicine that is FDA approved to
treat adults with a certain type of depression called major depressive disorder,
and for the prevention of autumn-winter seasonal depression (seasonal affective
disorder).
When prescribed off-label Bupropion may help some adults with overweight and
obesity lose weight and keep the weight off.
IMPORTANT SAFETY INFORMATION WARNING: CHANGES IN THINKING AND BEHAVIOR,
DEPRESSION, AND SUICIDAL THOUGHTS OR ACTIONS Suicidal Thoughts or Actions and
Antidepressant Drugs Antidepressants may increase the risk of suicidal thoughts
or actions in some children, teenagers, or young adults within the first few
months of treatment. Depression or other serious mental illnesses are the most
important causes of suicidal thoughts and actions. People who have (or have a
family history of) bipolar illness or suicidal thoughts or actions may have a
particularly high risk. Pay close attention to any changes, especially sudden
changes in mood, behaviors, thoughts, or feelings. Call your healthcare provider
right away if symptoms such as anxiety, irritability, impulsivity, trouble
sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you.
BUPROPION XL has not been evaluated for use in patients under the age of 18.
Call your healthcare provider right away if you or your family member has any of
the following symptoms, especially if they are new, worse, or worry you:
 * thoughts about suicide or dying
 * attempts to commit suicide
 * new or worse depression
 * new or worse anxiety
 * feeling very agitated or restless
 * panic attacks
 * trouble sleeping (insomnia)
 * new or worse irritability
 * acting aggressive, being angry, or violent
 * acting on dangerous impulses
 * an extreme increase in activity and talking (mania)
 * other unusual changes in behavior or mood

Although BUPROPION XL is not a treatment for quitting smoking, it contains the
same active ingredient (bupropion) as ZYBAN, which is used to help patients quit
smoking.
Some people have had serious side effects while taking bupropion to help them
quit smoking, including:
New or worse mental health problems, such as changes in behavior or thinking,
aggression, hostility, agitation, depression, or suicidal thoughts or actions.
Some people had these symptoms when they began taking bupropion, and others
developed them after several weeks of treatment, or after stopping bupropion.
These symptoms happened more often in people who had a history of mental health
problems before taking bupropion than in people without a history of mental
health problems.
Stop taking BUPROPION XL and call your healthcare provider right away if you,
your family, or caregiver notice any of these symptoms. Work with your
healthcare provider to decide whether you should continue to take BUPROPION XL.
In many people, these symptoms went away after stopping BUPROPION XL, but in
some people, symptoms continued after stopping BUPROPION XL. It is important for
you to follow-up with your healthcare provider until your symptoms go away.
What Other Important Information Should I Know About BUPROPION XL? Before taking
BUPROPION XL, tell your healthcare provider if you have ever had depression or
other mental health problems. You should also tell your healthcare provider
about any symptoms you had during other times you tried to quit smoking, with or
without bupropion. What Other Important Information Should I Know About
BUPROPION XL?
 * Seizures: There is a chance of having a seizure (convulsion, fit) with
   BUPROPION XL, especially in people with certain medical problems or who take
   certain medicines. Do not take any other medicines while you are taking
   BUPROPION XL unless your healthcare provider has said it is okay to take
   them. If you have a seizure while taking BUPROPION XL, stop taking the
   tablets and call your healthcare provider right away.
 * High blood pressure (hypertension): Some people get high blood pressure that
   can be severe while taking BUPROPION XL.
 * Manic episodes: Some people may have periods of mania while taking BUPROPION
   XL. If you have any of the following symptoms of mania, call your healthcare
   provider:
   * greatly increased energy
   * severe trouble sleeping
   * racing thoughts
   * reckless behavior
   * unusually grand ideas
   * excessive happiness or irritability
   * talking more or faster than usual
 * Unusual thoughts or behaviors: Some patients may have unusual thoughts or
   behaviors while taking BUPROPION XL, including delusions (e.g., believe you
   are someone else), hallucinations (seeing or hearing things that are not
   there), paranoia (feeling that people are against you), or feeling confused.
   If this happens to you, call your healthcare provider.
 * Visual problems: Some people are at risk of glaucoma which can present as:
   eye pain, changes in vision, or swelling and redness around the eye if they
   take BUPROPION XL. You should see an eye doctor to determine whether you are
   at risk prior to starting therapy.
 * Severe allergic reactions: Some patients have severe allergic reactions to
   WELLBUTRIN XL. Stop taking BUPROPION XL and call your healthcare provider
   right away if you get a rash, itching, hives, fever, swollen lymph glands,
   painful sores in the mouth or around the eyes, swelling of the lips or
   tongue, chest pain, or have trouble breathing. These could be signs of a
   serious allergic reaction.

Do not take BUPROPION XL if you:
 * have or had a seizure disorder or epilepsy
 * have or had an eating disorder such as anorexia nervosa or bulimia - are
   taking any other medicines that contain bupropion, including WELLBUTRIN or
   WELLBUTRIN SR, APLENZIN®, ZYBAN, or FORFIVO XL. Bupropion is the same active
   ingredient that is in WELLBUTRIN XL
 * drink a lot of alcohol and abruptly stop drinking, or use medicines called
   sedatives (these make you sleepy), benzodiazepines, or anti-seizure
   medicines, and you stop using them all of a sudden
 * take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or
   pharmacist if you are not sure if you take an MAOI, including the antibiotic
   linezolid
   * do not take an MAOI within 2 weeks of stopping BUPROPION XL unless directed
     to do so by your healthcare provider
   * do not start BUPROPION XL if you stopped taking an MAOI in the last 2 weeks
     unless directed to do so by your healthcare provider
 * are allergic to the active ingredient in BUPROPION XL, bupropion, or to any
   of the inactive ingredients

Although BUPROPION XL is not a treatment for quitting smoking, it contains the
same active ingredient (bupropion) as ZYBAN, which is used to help patients quit
smoking. Before taking BUPROPION XL, tell your healthcare provider if you have
ever had depression, suicidal thoughts or actions, or other mental health
problems or any symptoms you had during other times you tried to quit smoking
with or without bupropion. Also, tell your healthcare provider about your other
medical conditions, including if you:
 * have liver problems, especially cirrhosis of the liver
 * have kidney problems
 * have, or have had, an eating disorder such as anorexia nervosa or bulimia
 * have had a head injury
 * have had a seizure (convulsion, fit)
 * have a tumor in your nervous system (brain or spine)
 * have had a heart attack, heart problems, or high blood pressure
 * are a diabetic taking insulin or other medicines to control your blood sugar
 * drink alcohol
 * abuse prescription medicines or street drugs
 * are pregnant or plan to become pregnant. Talk to your healthcare provider
   about the risk to your unborn baby if you take BUPROPION XL during pregnancy,
   and about registering with the National Pregnancy Registry by calling
   1-844-405-6185
 * are breastfeeding. BUPROPION XL passes into your milk in small amounts

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.
Many medicines increase your chances of having seizures or cause other serious
side effects if you take them while you are using BUPROPION XL.
The most common side effects of BUPROPION XL include: trouble sleeping, stuffy
nose, dry mouth, dizziness, feeling anxious, nausea, constipation, and joint
aches.
These are not all the side effects of BUPROPION XL. You are encouraged to report
negative side effects of prescription drugs to the FDA. Visit
www.fda.gov/medwatch or call 1-800-FDA-1088.
The health information contained herein is provided for educational purposes
only and is not intended to replace discussions with a healthcare provider. All
decisions regarding patient care must be made with a healthcare provider,
considering the unique characteristics of the patient. The product information
provided is intended only for residents of the United States. The products
discussed herein may have different product labeling in different countries.


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