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INNOVATION IN MITOCHONDRIAL HEALTH


Take Our Survey

WHAT WE DO


OUR VALUE PROPOSITIONS.




Click on each of our three value propositions below to find out more about our
offering and how it may be of benefit to you.

N

OVER 100 MITOCHONDRIAL HEALTH PARAMETERS

Comprehensive reports covering many aspects of mitochondrial health enable
informed decisions to be made.

Learn More
N

IMPROVED TRANSLATION CONFIDENCE

The use of patient-derived cells are accurate disease relevant models, improving
confidence in translation.

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N

VALUABLE IND APPLICATION EVIDENCE

Efficacy data in accurate human cell based models can provide valuable evidence
for an IND application.

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A COMPREHENSIVE EVALUATION OF MITOCHONDRIAL HEALTH





Our state of the art techniques offer miniaturisation of complex biological
assays in patient-derived cells enabling us to run high throughput screens to
measure hundreds of mitochondrial health parameters.

We can measure function, morphology, localisation, mtDNA, mitochondria
interactions with other organelles and mitochondrial ROS production in 1536 well
plates in patient cells.

Further exploration of respiration, fuel consumption, mitophagy and many other
aspects of mitochondrial biology can be investigated in in-depth screens in
primary cells and induced cell types such as iNeurons and iAstrocytes.

We can also provide data on cell health, including cell viability, morphology
and apoptotic markers.

This enables customers to confidently make well informed decisions about
compound progression and stop compounds that would often be identified as
ineffective at later stages of discovery. This will save time and money.

Why settle for less when you can have more for the same price?

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TRANSLATION





Complex diseases such as neurodegeneration are incredibly hard to replicate in
the lab. Patient-derived cells provide the closest representative model of these
diseases.

The use of patient-derived cells enables the collection of data for IND
applications and reduces the use of animal models, presenting a more ethical
option.

Compound efficacy in patient-derived cell lines improves the confidence that the
compound will be successful in patients.

At mitotype, we use patient-derived cells in early drug discovery enabling rapid
termination of ineffective compounds saving companies money.

Our screening in patient-derived cells is as fast as other conventional generic
cell models.

Patient-derived cells can also be reprogrammed to enable the production of cell
types that cannot be biopsied.

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INVESTIGATIONAL NEW DRUG APPLICATION





The FDA Modernization Act 2.0, passed in 2022, authorises the use of cell-based
models instead of animal models to investigate drug safety and effectiveness

Our patient-derived cells provide strong models to collect data proving compound
mechanisms and effectiveness for IND applications.

Our in-depth analysis would provide comprehensive reports for approval.

The use of cell models dramatically reduces the use of animals presenting a more
ethical option.

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GET IN TOUCH WITH OUR TEAM!




If you would like any further information please get in touch via the form below
or email tjburgess1@sheffield.ac.uk

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Mitotype Precision Labs 2024
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