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POST //primeinc.org/virtual/new-evidence-hypertrophic-cardiomyopathy-examining-implications-managed-care?utm_campaign=17VS212&utm_source=prime&utm_medium=email&hr=prime&action=reg&mh=d9d3de510378e6ffc0b6f8a4ba7965db

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        <p>What question(s) do you have for the expert faculty about the diagnosis, treatment, or management of patients with HCM? We will use these questions to tailor our content to your needs.</p>
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POST //primeinc.org/virtual/new-evidence-hypertrophic-cardiomyopathy-examining-implications-managed-care?utm_campaign=17VS212&utm_source=prime&utm_medium=email&hr=prime&action=reg&mh=d9d3de510378e6ffc0b6f8a4ba7965db

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              <input id="s1923_ans69691" name="answer[14004][multi-select][]" type="checkbox" value="69691"> <span class="answer" data-id="69691">
                <p>Safety/risk management</p>
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              <input id="s1923_ans69692" name="answer[14004][multi-select][]" type="checkbox" value="69692"> <span class="answer" data-id="69692">
                <p>Coordination of care or care transitions</p>
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        <p>The most common pathogenic variants (ie, mutations) implicated in HCM affect which of the following proteins?</p>
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                <p>Cardiac ryanodine receptor</p>
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                <p>Voltage-gated sodium channels</p>
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                <p>Cardiac sarcomere</p>
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              <input id="s1923_ans69711" name="answer[14009][single-select][]" type="radio" value="69711"> <span class="answer" data-id="69711">
                <p>Voltage-gated potassium channels</p>
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          <div>
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              <input id="s1923_ans69712" name="answer[14009][single-select][]" type="radio" value="69712"> <span class="answer" data-id="69712">
                <p>Endothelial nitric oxide synthase</p>
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      </div><!-- .answer-area -->
    </div>
    <div id="questionblock1923_14010" class="questionblock " data-section="" data-sectiontitle="" style="display: none;">
      <input type="hidden" class="skipme" name="skipme[14010]" value="0">
      <div class="question ">
        <p>Which of the following statements best represents your interpretation of new data from the EXPLORER-HCM cardiovascular outcomes trial?</p>
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      <div class="answerarea">
        <fieldset>
          <legend class="sr-only" style="visibility: hidden;">Which of the following statements best represents your interpretation of new data from the EXPLORER-HCM cardiovascular outcomes trial?</legend>
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            <label for="s1923_ans69713" class="single single-select">
              <input id="s1923_ans69713" name="answer[14010][single-select][]" type="radio" value="69713"> <span class="answer" data-id="69713">
                <p>Although left ventricular outflow tract (LVOT) obstruction was improved, there was no clear benefit on functional capacity for patients treated with mavacamten</p>
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          <div>
            <label for="s1923_ans69714" class="single single-select">
              <input id="s1923_ans69714" name="answer[14010][single-select][]" type="radio" value="69714"> <span class="answer" data-id="69714">
                <p>There was no significant difference in LVOT or functional status between the treatment arms</p>
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          <div>
            <label for="s1923_ans69715" class="single single-select">
              <input id="s1923_ans69715" name="answer[14010][single-select][]" type="radio" value="69715"> <span class="answer" data-id="69715">
                <p>Although mavacamten showed benefit in exercise capacity, I have concerns about overall cardiovascular risk reduction</p>
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          </div>
          <div>
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              <input id="s1923_ans69716" name="answer[14010][single-select][]" type="radio" value="69716"> <span class="answer" data-id="69716">
                <p>Improvement in LVOT obstruction, NYHA functional class, and health status was demonstrated with mavacamten treatment</p>
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          <div>
            <label for="s1923_ans69717" class="single single-select">
              <input id="s1923_ans69717" name="answer[14010][single-select][]" type="radio" value="69717"> <span class="answer" data-id="69717">
                <p>Given the short trial duration and narrow inclusion criteria, more data are needed to support the usefulness of mavacamten</p>
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      </div><!-- .answer-area -->
    </div>
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      <div class="question ">
        <p>Rate your level of confidence in differentiating conventional and emerging therapies for HCM.</p>
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        <fieldset>
          <legend class="sr-only" style="visibility: hidden;">Rate your level of confidence in differentiating conventional and emerging therapies for HCM.</legend>
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                <p>Very high</p>
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              <input id="s1923_ans69719" name="answer[14011][single-select][]" type="radio" value="69719"> <span class="answer" data-id="69719">
                <p>High</p>
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              <input id="s1923_ans69720" name="answer[14011][single-select][]" type="radio" value="69720"> <span class="answer" data-id="69720">
                <p>Moderate</p>
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              <input id="s1923_ans69721" name="answer[14011][single-select][]" type="radio" value="69721"> <span class="answer" data-id="69721">
                <p>Low</p>
              </span> </label>
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              <input id="s1923_ans69722" name="answer[14011][single-select][]" type="radio" value="69722"> <span class="answer" data-id="69722">
                <p>Very low</p>
              </span> </label>
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        <p>Aside from cost, what are the top two factors you consider when differentiating among available and emerging therapies for HCM? (Select 2)</p>
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          <legend class="sr-only" style="visibility: hidden;">Aside from cost, what are the top two factors you consider when differentiating among available and emerging therapies for HCM? (Select 2)</legend>
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              <input id="s1923_ans69723" name="answer[14012][multi-select][]" type="checkbox" value="69723"> <span class="answer" data-id="69723">
                <p>Extent of symptomatic relief</p>
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          <div>
            <label for="s1923_ans69724" class="multi multi-select">
              <input id="s1923_ans69724" name="answer[14012][multi-select][]" type="checkbox" value="69724"> <span class="answer" data-id="69724">
                <p>Targeting disease-specific mechanisms</p>
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                <p>Risk reduction of sudden cardiac death (SCD)</p>
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              <input id="s1923_ans69726" name="answer[14012][multi-select][]" type="checkbox" value="69726"> <span class="answer" data-id="69726">
                <p>Impact on healthcare utilization</p>
              </span> </label>
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              <input id="s1923_ans69727" name="answer[14012][multi-select][]" type="checkbox" value="69727"> <span class="answer" data-id="69727">
                <p>Impact on New York Heart Association (NYHA) functional class</p>
              </span> </label>
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              <input id="s1923_ans69728" name="answer[14012][multi-select][]" type="checkbox" value="69728"> <span class="answer" data-id="69728">
                <p>Impact on patient quality of life</p>
              </span> </label>
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        <p>What do you foresee will be the greatest barrier for payers regarding the use of emerging therapies for HCM?</p>
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        <fieldset>
          <legend class="sr-only" style="visibility: hidden;">What do you foresee will be the greatest barrier for payers regarding the use of emerging therapies for HCM?</legend>
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              <input id="s1923_ans69735" name="answer[14014][single-select][]" type="radio" value="69735"> <span class="answer" data-id="69735">
                <p>Overcoming inertia to changing current practices</p>
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              <input id="s1923_ans69736" name="answer[14014][single-select][]" type="radio" value="69736"> <span class="answer" data-id="69736">
                <p>Overcoming efficacy and safety concerns</p>
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              <input id="s1923_ans69737" name="answer[14014][single-select][]" type="radio" value="69737"> <span class="answer" data-id="69737">
                <p>Defining patient eligibility for formulary management</p>
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              <input id="s1923_ans69738" name="answer[14014][single-select][]" type="radio" value="69738"> <span class="answer" data-id="69738">
                <p>Defining step therapy requirements</p>
              </span> </label>
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              <input id="s1923_ans69739" name="answer[14014][single-select][]" type="radio" value="69739"> <span class="answer" data-id="69739">
                <p>Demonstrating cost-effectiveness</p>
              </span> </label>
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                <p>Other</p>
              </span>: </label><input id="1923_ans69740" class="form-control free freesingle" name="answer[14014][free-response][69740]" type="text">
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NEW EVIDENCE IN HYPERTROPHIC CARDIOMYOPATHY: EXAMINING IMPLICATIONS FOR MANAGED
CARE



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VIRTUAL SYMPOSIUM SNAPSHOT

Activity Type:
Virtual Symposium
Duration:
1 hours 15 minutes
Intended Location:
Denver, CO
Total Price:
Free

Broadcast Date:
 * Monday, Oct 18, 2021 at 7:15 PM Mountain


Continuing Education Credits:
 * 1.25 CME/CE for Physicians (ACCME)
 * 1.25 CME/CE for Physician Assistants (AAPA)
 * 1.25 CH/CE for Nurse Practitioners (AANP)
 * 1.25 CPE for Pharmacists (ACPE + NABP)
 * 1.25 CNE for Nurses (ANCC)


FACULTY


EDWARD A GILL, MD, FASE, FAHA, FACC, FACP, FNLA

Speaker


Professor of Medicine, Division of Cardiology
Director, Interventional Echocardiography
University of Colorado School of Medicine
Aurora, CO





STEVE R OMMEN, MD, FACC, FAHA

Speaker


Professor of Medicine
Department of Cardiovascular Diseases
Director, Hypertrophic Cardiomyopathy Clinic
Mayo Clinic College of Medicine
Rochester, MN





PATTY TADDEI-ALLEN, PHARMD, MBA, BCACP, BCGP

Moderator


Vice President, Clinical Programs and Services
WellDyneRx
Lakeland, FL





DONNA M CHIEFARI, BSC (PHARM), PHARMD, RPH, FASHP

Planner

Adjunct Faculty & Preceptor
Albany College of Pharmacy
Albany, NY





JUDITH R SANDS, RN, MSL, BSN, CCM, CPHQ, CPHRM, ARM

Planner

Clinical Consultant
Raleigh, NC





HENRY A SOLOMON, MD, FACP, FACC

Peer Reviewer

Cardiologist and Internal Medicine Physician
New York, NY





AGENDA

 I.   HCM Disease Progression: Journey of the Patient
 II.  Latest Clinical Evidence on Current and Emerging Therapies in HCM
 III. Applications of New Clinical Data for Managed Care Decision-Making
 IV.  Managed Care Strategies for Quality, Equitable Care to Optimize HCM
      Treatment Outcomes


LEARNING OBJECTIVES

 * Summarize recent clinical findings on pathophysiological mechanisms that
   underlie disease progression in hypertrophic cardiomyopathy (HCM)
 * Differentiate the utility of therapies for HCM based on mechanisms of action
   and clinical data on efficacy and safety
 * Align decision-making with current evidence, treatment guidelines, and
   patient factors to ensure appropriate patient selection and prompt access to
   HCM therapies

 * Overview
 * CE Details & Instructions
 * Faculty Disclosures



Intended Audience: Managed Care Pharmacy Directors, Medical Directors,
Pharmacists, and Medication Therapy Management (MTM) Nurses (pharmacists,
physicians, nurses)



Hypertrophic cardiomyopathy (HCM) is currently managed through symptomatic
treatment or surgical intervention. Join leading managed care and HCM experts as
they discuss the latest clinical data on emerging therapies and applications for
managed care decision-making to optimize outcomes for patients with this
devastating disease.

Don't miss this opportunity to:

 * Hear about new clinical data on emerging therapies in HCM
 * Learn about applications of new evidence on managed care decision-making for
   patients with HCM
 * Engage in live Q&A with renowned experts in HCM

This can't-miss live session is designed to provide extensive interactive
learning, peer discussion, and dedicated time for Q&A.






ACCREDITATION INFORMATION


JOINT ACCREDITATION STATEMENT

In support of improving patient care, PRIME® is jointly accredited by the
Accreditation Council for Continuing Medical Education (ACCME), the
Accreditation Council for Pharmacy Education (ACPE), and the American Nurses
Credentialing Center (ANCC) to provide continuing education for the healthcare
team.


INTERPROFESSIONAL TEAMS

This activity was planned by and for the healthcare team, and learners will
receive 1.25 Interprofessional Continuing Education (IPCE) credits for learning
and change.


PHYSICIAN CREDIT DESIGNATION STATEMENT

PRIME® designates this Live activity for a maximum of 1.25 AMA PRA Category 1
Credits™. Physicians should claim only credit commensurate with the extent of
their participation in the activity.


MOC POINTS

Successful completion of this CME activity, which includes participation in the
evaluation component, enables the participant to earn up to 1.25 Medical
Knowledge MOC points in the American Board of Internal Medicine's (ABIM)
Maintenance of Certification (MOC) program. Participants will earn MOC points
equivalent to the amount of CME credits claimed for the activity. It is the CME
activity provider's responsibility to submit participant completion information
to ACCME for the purpose of granting ABIM MOC credit.




PHYSICIAN ASSISTANT ACCREDITATION STATEMENT

PRIME® has been authorized by the American Academy of PAs (AAPA) to award AAPA
Category 1 CME credits for activities planned in accordance with AAPA CME
Criteria. This activity is designated for 1.25 AAPA Category 1 CME credits. PAs
should only claim credit commensurate with the extent of their participation.


NURSE PRACTITIONER ACCREDITATION STATEMENT

PRIME Education is accredited by the American Association of Nurse Practitioners
as an approved provider of nurse practitioner continuing education. Provider
number: 060815. This activity is approved for 1.25 contact hours (which includes
0.7 hour of pharmacology).


PHARMACIST ACCREDITATION STATEMENT

This Application-based activity has been approved for 1.25 contact hours (0.125
CEUs) by PRIME® for pharmacists. The Universal Activity Number for this activity
is JA0007144-0000-21-167-L01-P . Pharmacy CE credits can be submitted to the
NABP upon successful completion of the activity by providing your NABP ID & DOB,
which must be submitted within 60 days of completion. Pharmacists with questions
can contact NABP customer service (help@nabp.pharmacy).




NURSE ACCREDITATION STATEMENT

PRIME® designates this activity for 1.25 contact hours.


OBTAINING CE CREDIT

 1. Register using the online form
 2. Complete the pre-registration survey
 3. Attend the live program in its entirety
 4. Complete an online evaluation and post-test
 5. Download and/or print a certificate of completion and/or submit CE credits
    electronically

Instructions to access CME/CE credit options will be provided at the end of the
program.


METHOD OF PARTICIPATION

This live CME/CE activity requires attendance of the participant during the
entire program and completion of learner assessment tools. The learner will then
receive instructions on how to download and/or print a certificate of completion
and/or submit CE credits electronically.


DEVICE REQUIREMENTS

 * Hardware: an Internet-enabled computer, smartphone, tablet, or mobile device
   with audio capabilities and Internet connectivity
 * Software: the installation of software such as GoToWebinar may be required

The following individuals have no relevant financial relationships with
commercial interests to disclose:

 * Edward A Gill, MD, FASE, FAHA, FACC, FACP, FNLA (Speaker)
 * Steve R Ommen, MD, FACC, FAHA (Speaker)
 * Patty Taddei-Allen, PharmD, MBA, BCACP, BCGP (Moderator)
 * Henry A Solomon, MD, FACP, FACC (Reviewer)
 * Donna M Chiefari, BSc (Pharm), PharmD, RPh, FASHP (Planner)
 * Judith R Sands, RN, MSL, BSN, CCM, CPHQ, CPHRM, ARM (Planner)

All PRIME staff participating in planning and content development have no
relevant financial relationships with commercial interests to disclose.




FUNDING DISCLOSURE

This activity is provided by PRIME Education. There is no fee to participate.
This activity is supported by an educational grant from Bristol Myers Squibb.




ACCESSIBILITY STATEMENT

At PRIME, we are committed to ensuring that individuals with disabilities can
access all of the content offered by PRIME through our website and other
properties. If you are having trouble accessing primeinc.org, please email
legal@ziffdavis.com for assistance. Please put "ADA Inquiry" in the subject line
of your email.


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REGISTRATION PRE-SURVEY

To confirm your registration, please complete this short survey.


0%

Approximately how many patients with hypertrophic cardiomyopathy (HCM) does your
organization impact monthly?

Approximately how many patients with hypertrophic cardiomyopathy (HCM) does your
organization impact monthly?

Number of patients

:

Please indicate your work setting:

Please indicate your work setting:

Health plan

Specialty pharmacy

Pharmacy benefit manager

Employer

Government program

Health system or academia

Health outcomes

Managed care support service

Other

:

What is your role? (Select all that apply)

What is your role? (Select all that apply)

Medication eligibility determination

Review of treatment guidelines or new therapies

Formulary decision-making

Medication counseling for providers/patients

Medication reconciliation

Safety/risk management

Coordination of care or care transitions

Other

:

Which of the following treatments selectively inhibits cardiac myosin ATPase?

Which of the following treatments selectively inhibits cardiac myosin ATPase?

Bisoprolol

Verapamil

Diltiazem

Mavacamten

Disopyramide

Rate your level of agreement with the following statement: There is an unmet
disease burden for hypertrophic cardiomyopathy (HCM) in the context of available
therapeutic options.

Rate your level of agreement with the following statement: There is an unmet
disease burden for hypertrophic cardiomyopathy (HCM) in the context of available
therapeutic options.

Strongly agree

Agree

Neutral

Disagree

Strongly disagree

What question(s) do you have for the expert faculty about the diagnosis,
treatment, or management of patients with HCM? We will use these questions to
tailor our content to your needs.

What question(s) do you have for the expert faculty about the diagnosis,
treatment, or management of patients with HCM? We will use these questions to
tailor our content to your needs.

Questions

:


No questions


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JOIN THE LIVE WEBINAR

Please complete this short survey before joining.


0%

Approximately how many patients with hypertrophic cardiomyopathy (HCM) does your
organization impact monthly?

Approximately how many patients with hypertrophic cardiomyopathy (HCM) does your
organization impact monthly?

Number of patients

:

Please indicate your work setting:

Please indicate your work setting:

Health plan

Specialty pharmacy

Pharmacy benefit manager

Employer

Government program

Health system or academia

Health outcomes

Managed care support service

Other

:

What is your role? (Select all that apply)

What is your role? (Select all that apply)

Medication eligibility determination

Review of treatment guidelines or new therapies

Formulary decision-making

Medication counseling for providers/patients

Medication reconciliation

Safety/risk management

Coordination of care or care transitions

Other

:

The most common pathogenic variants (ie, mutations) implicated in HCM affect
which of the following proteins?

The most common pathogenic variants (ie, mutations) implicated in HCM affect
which of the following proteins?

Cardiac ryanodine receptor

Voltage-gated sodium channels

Cardiac sarcomere

Voltage-gated potassium channels

Endothelial nitric oxide synthase

Which of the following statements best represents your interpretation of new
data from the EXPLORER-HCM cardiovascular outcomes trial?

Which of the following statements best represents your interpretation of new
data from the EXPLORER-HCM cardiovascular outcomes trial?

Although left ventricular outflow tract (LVOT) obstruction was improved, there
was no clear benefit on functional capacity for patients treated with mavacamten

There was no significant difference in LVOT or functional status between the
treatment arms

Although mavacamten showed benefit in exercise capacity, I have concerns about
overall cardiovascular risk reduction

Improvement in LVOT obstruction, NYHA functional class, and health status was
demonstrated with mavacamten treatment

Given the short trial duration and narrow inclusion criteria, more data are
needed to support the usefulness of mavacamten

Rate your level of confidence in differentiating conventional and emerging
therapies for HCM.

Rate your level of confidence in differentiating conventional and emerging
therapies for HCM.

Very high

High

Moderate

Low

Very low

Aside from cost, what are the top two factors you consider when differentiating
among available and emerging therapies for HCM? (Select 2)

Aside from cost, what are the top two factors you consider when differentiating
among available and emerging therapies for HCM? (Select 2)

Extent of symptomatic relief

Targeting disease-specific mechanisms

Risk reduction of sudden cardiac death (SCD)

Impact on healthcare utilization

Impact on New York Heart Association (NYHA) functional class

Impact on patient quality of life

What do you foresee will be the greatest barrier for payers regarding the use of
emerging therapies for HCM?

What do you foresee will be the greatest barrier for payers regarding the use of
emerging therapies for HCM?

Overcoming inertia to changing current practices

Overcoming efficacy and safety concerns

Defining patient eligibility for formulary management

Defining step therapy requirements

Demonstrating cost-effectiveness

Other

:


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Service apply.

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Federal Government
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Specialty…Family Medicine Neurology Internal Medicine Hematology / Oncology
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Pain Management Med / Surg Allergy / Immunology Pulmonology Rheumatology
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Ophthalmology Pathology Hepatology Urology Genetic Disorders Neonatal /
Perinatal Otolaryngology Oncology Other None
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