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BioProcess International is part of the Informa Connect Division of Informa PLC Informa PLC|ABOUT US|INVESTOR RELATIONS|TALENT This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC's registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726. BPI EventsAboutSubscribeContribute Subscribe Subscribe REGISTERSign in Upstream RELATED TOPICS * Bioreactors * Biochemicals/Raw Materials * Cell Culture Media * Expression Platforms * Microbial Cell Culture * Perfusion Cell Culture RECENT IN UPSTREAM See all Bispecific Antibodies Unleashed Sponsored Content Bispecific Antibodies UnleashedBispecific Antibodies Unleashed byBPI Contributor Nov 2, 2023 1 Min Read Working Toward an AAV Platform: Challenges, Threats, and Opportunities Sponsored Content Working Toward an AAV Platform: Challenges, Threats, and OpportunitiesWorking Toward an AAV Platform: Challenges, Threats, and Opportunities byMégane Denu, Quentin Bazotand 1 more Oct 20, 2023 Downstream RELATED TOPICS * Chromatography * Filtration * Separation/Purification * Viral Clearance RECENT IN DOWNSTREAM See all A Scalable Single-Use Two-Step Plasmid Purification Process Sponsored Content A Scalable Single-Use Two-Step Plasmid Purification ProcessA Scalable Single-Use Two-Step Plasmid Purification Process byBPI Contributor Nov 3, 2023 20 Min View Minimizing Lentiviral Vector Loss During the Purification Process Using an Innovative Nanofiber Adsorbent Sponsored Content Minimizing Lentiviral Vector Loss During the Purification Process Using an Innovative Nanofiber AdsorbentMinimizing Lentiviral Vector Loss During the Purification Process Using an Innovative Nanofiber Adsorbent byBPI Contributor Oct 31, 2023 20 Min View Manufacturing RELATED TOPICS * Biosimilars * Continuous Bioprocessing * Facility Design/Engineering * Formulation * Single Use * Fill/Finish * Information Technology * Process Monitoring and Controls * Supply Chain * Validation * CMC Forums RECENT IN MANUFACTURING See all thumbnail Bioprocess Insider Breyanzi: BMS seeking to expand outreach of lymphoma therapyBreyanzi: BMS seeking to expand outreach of lymphoma therapy byJosh Abbott Aug 22, 2024 3 Min Read thumbnail Bioprocess Insider Fujifilm expands UK manufacturing space with one eye on the futureFujifilm expands UK manufacturing space with one eye on the future byJosh Abbott Aug 22, 2024 2 Min Read Analytical RELATED TOPICS * QA/QC * Cell Line Development * PAT * Product Characterization * Bioanalytical Methods * Process Development * Assays * Laboratory Equipment RECENT IN ANALYTICAL See all Test - Juan - Article Analytical Test - Juan - ArticleTest - Juan - Article byAdrianna Milewska May 3, 2024 1 Min Read The Key Role of Analytical Methods in Technology Transfer Sponsored Content The Key Role of Analytical Methods in Technology TransferThe Key Role of Analytical Methods in Technology Transfer byOlena Chervonenko Oct 17, 2023 Business RELATED TOPICS * Bioregions * Careers & Training * Contract Services * Economics * Pre-Clinical & Clinical Trials * Risk Management * Intellectual Property * Regulatory Affairs RECENT IN BUSINESS See all thumbnail Bioprocess Insider Key strategies for effective technology evaluationKey strategies for effective technology evaluation byKim Bennett Aug 8, 2024 2 Min Read Resilience logo Sponsored Content Built to Serve Innovation: A Briefing on Commercial Readiness at ResilienceBuilt to Serve Innovation: A Briefing on Commercial Readiness at Resilience byBPI Contributor Jun 25, 2024 15 Min View Therapeutic Modalities RELATED TOPICS * Cell Therapies * Emerging Therapeutics * Gene Therapies * Large Molecule Development * MAb * Personalized Medicine * Vaccines RECENT IN THERAPEUTIC MODALITIES See all thumbnail Bioprocess Insider Biomanufacturing in space accelerating therapy development on EarthBiomanufacturing in space accelerating therapy development on Earth byJosh Abbott Jul 24, 2024 3 Min Read DNA Synthesis: Chemical, Enzymatic, or Both? Therapeutic Modalities DNA Synthesis: Chemical, Enzymatic, or Both?DNA Synthesis: Chemical, Enzymatic, or Both? byMark Behlke Oct 20, 2023 BioProcess Insider RELATED TOPICS * Deal-Making * Facilities & Capacity * Global Markets * Regulations * Therapeutic Class * Upstream & Downstream Processing * Webcasts * BioProcess Insider Podcasts RECENT IN BIOPROCESS INSIDER See all thumbnail Facilities & Capacity Symbiosis doubles Scotland footprint with $34m investmentSymbiosis doubles Scotland footprint with $34m investment byShreeyashi Ojha Sep 9, 2024 2 Min Read SmartLabs Sponsored Content Adapting to Growth: Innovative Lab Solutions for the Evolving Cell and Gene Therapy MarketAdapting to Growth: Innovative Lab Solutions for the Evolving Cell and Gene Therapy Market byBPI Contributor Sep 6, 2024 3 Min Read INSIDER NEWS ELI LILLY BOOSTS IRISH MANUFACTURING WITH $1.8BN EXPANSION Sep 13, 2024 CELLULAR AND 3P PARTNER TO BOLSTER CGT MANUFACTURING Sep 13, 2024 CATALENT PAVES THE WAY FOR NOVO’S US GLP-1 EXPANSION Sep 13, 2024 CELLARES AND SONY PARTNER TO AUTOMATE CELL THERAPY MANUFACTURING Sep 12, 2024 Read More scientist looking into microscope Continuous Bioprocessing INCREASING ACCESS THROUGH CONTINUOUS BIOMANUFACTURING INCREASING ACCESS THROUGH CONTINUOUS BIOMANUFACTURING Jul 29, 2024 scientist at tank From the Editor From the Editor: Drug Substance From the Editor: Drug Substance Jul 29, 2024 scientists in lab Emerging Therapeutics Rare-Disease Research: Its Importance for Orphan-Drug Development Success Rare-Disease Research: Its Importance for Orphan-Drug Development Success Jul 29, 2024 LATEST ISSUE July-August 2024 Issue Current Issue Read Now Raw Materials: Logistics and Analysis Featured Report Read Now Special Report From Pipettes to Infusion Pumps: Volume Accuracy in Regulated Industries and Its Critical Impact Read Now Archive Upstream Processing BPI Theater panelists Expression Platforms Improving Expression and Manufacturing of Novel Biologics Improving Expression and Manufacturing of Novel Biologics Jul 31, 2024 turbulent flow image Bioreactors Lessons in Bioreactor Scale-Up, Part 2: A Refresher on Fluid Flow and Mixing Lessons in Bioreactor Scale-Up, Part 2: A Refresher on Fluid Flow and Mixing Jun 12, 2024 Sponsored Content Empowering Biologic Breakthroughs: Transforming Tomorrow’s Healthcare Landscape Through Microbial-Based Development and Manufacturing Empowering Biologic Breakthroughs: Transforming Tomorrow’s Healthcare Landscape Through Microbial-Based Development and Manufacturing Mar 28, 2024 View More Downstream Processing quantitative venn diagram Sponsored Content LC-MS Detection of Host Cell Proteins: Antibody Affinity Extraction Sample Preparation Outperforms Native Digestion LC-MS Detection of Host Cell Proteins: Antibody Affinity Extraction Sample Preparation Outperforms Native Digestion Jul 29, 2024 Simplifying Downstream Processing: Innovative Solutions for Filtration and Chromatography Cover Sponsored Content Simplifying Downstream Processing: Innovative Solutions for Filtration and Chromatography Simplifying Downstream Processing: Innovative Solutions for Filtration and Chromatography Jun 12, 2024 Navigating Biotherapeutic Complexity: Tailored Chromatography Resins to Enable Purification Success Sponsored Content Navigating Biotherapeutic Complexity: Tailored Chromatography Resins to Enable Purification Success Navigating Biotherapeutic Complexity: Tailored Chromatography Resins to Enable Purification Success Jun 12, 2024 View More Manufacturing eBook cover Sponsored Content eBook: Drug Delivery — New Formats for Novel Biopharmaceuticals eBook: Drug Delivery — New Formats for Novel Biopharmaceuticals Jun 26, 2024 buffer design workflow Information Technology Buffer Design for Biopharmaceutical Processes: An Online Tool for Designing and Understanding Buffers Buffer Design for Biopharmaceutical Processes: An Online Tool for Designing and Understanding Buffers Jun 19, 2024 digital globe Information Technology Keys to Successful Technology Transfer Keys to Successful Technology Transfer Jun 12, 2024 View More Analytical Cell Therapies Analytical Considerations for Gene-Modified Hematopoietic Stem and Progenitor Cell Therapies: Part 1 — In-Process and Drug Product Control Analytical Considerations for Gene-Modified Hematopoietic Stem and Progenitor Cell Therapies: Part 1 — In-Process and Drug Product Control QA/QC Practical Applications of Process Capability Indices in the Biopharmaceutical Industry: A Simulation-Based Study Practical Applications of Process Capability Indices in the Biopharmaceutical Industry: A Simulation-Based Study Corrective and preventive actions QA/QC Determining Sample Size for Demonstrating Zero Failures: Ensuring the Effectiveness of Corrective and Preventive Actions Determining Sample Size for Demonstrating Zero Failures: Ensuring the Effectiveness of Corrective and Preventive Actions View More Business scientist at computer Bioregions US–India Collaborative Innovations for Rapid Drug Discovery US–India Collaborative Innovations for Rapid Drug Discovery Outsourcing — India's Burgeoning Biologics CDMO Marketplace eBook Cover Sponsored Content eBook: Outsourcing — India's Burgeoning Biologics CDMO Marketplace eBook: Outsourcing — India's Burgeoning Biologics CDMO Marketplace business man in choppy waters Economics Navigating Choppy Waters: Three Resilient Marketing Tactics for Biotechnology Companies amid Market Turmoil Navigating Choppy Waters: Three Resilient Marketing Tactics for Biotechnology Companies amid Market Turmoil View More Therapeutic Modalities handshake Cell Therapies Elevating the CGT Manufacturing Game: How Outsourcing Enables Success Elevating the CGT Manufacturing Game: How Outsourcing Enables Success Allogeneic Cell Therapy eBook cover Sponsored Content eBook: Allogeneic Cell Therapy — From Clinical Concept to Viable Product eBook: Allogeneic Cell Therapy — From Clinical Concept to Viable Product Macroscopic macrophage image Emerging Therapeutics A Milestone in Macrophage-Based Cancer Treatment: Leveraging Chimeric Antigen Receptors To Address Solid Tumors A Milestone in Macrophage-Based Cancer Treatment: Leveraging Chimeric Antigen Receptors To Address Solid Tumors View More LATEST EBOOKS See All Cell TherapieseBook: Challenges of Commerical-Scale Autologous CAR-T Cell ManufacturingeBook: Challenges of Commerical-Scale Autologous CAR-T Cell Manufacturing Fill/FinisheBook: Drug Delivery — New Formats for Novel BiopharmaceuticalseBook: Drug Delivery — New Formats for Novel Biopharmaceuticals Cell TherapieseBook: Allogeneic Cell Therapy — From Clinical Concept to Viable ProducteBook: Allogeneic Cell Therapy — From Clinical Concept to Viable Product Special Reports Sponsored Content Scaling Up mAb Production with a Platform Medium and Feed SystemScaling Up mAb Production with a Platform Medium and Feed System As the monoclonal-antibody (mAb) market continues to grow, it is becoming increasingly important for pharmaceutical and biotech companies to accelerate process development and establish a scalable manufacturing process capable of achieving high titers and consistent product quality. Central to this is a cell culture media and feed system that can provide the required nutrients for optimal cell growth, viability, and function, as well as facilitate a seamless transition from development to clinical and commercial manufacturing. However, choosing an appropriate system can be a complex and time-consuming process, often requiring the evaluation of multiple medium and feed options. Platform systems, consisting of a medium and complementary feed developed for a specific cell line and application, have emerged as a valuable option for developers to help simplify selection and increase scale-up efficiency. To meet the need for high-performance platform mAb manufacturing solutions, Thermo Fisher Scientific has dev... Sponsored Content From Pipettes to Infusion Pumps: Volume Accuracy in Regulated Industries and Its Critical ImpactFrom Pipettes to Infusion Pumps: Volume Accuracy in Regulated Industries and Its Critical Impact Precision in volume delivery is critically important for both the biopharmaceutical and medical device industries. This special report discusses how accurate volume measurement affects patient safety, product quality, and regulatory compliance. Sartorius emphasizes the roles that infusion pumps, laboratory pipettes, and quality control (QC) measures play in ensuring reliable and reproducible results. Register or Login and hit Download Now to get the full Special Report. See all Ask the Expert Webcasts Sponsored Content Process Intensification Through Perfused N-1 BioreactorProcess Intensification Through Perfused N-1 Bioreactor This webcast features: Marissa Dickson, Scientist II, & Brian Hadley, Principal Scientist, Lonza Biologics. One strategy for lowering cost of goods (CoGs) of biotherapeutics manufacturing is by dramatically increasing the productivity of the bioreactor process. Lonza R&D has developed an intensified process that couples a perfused N-1 inoculum bioreactor, enabled by alternating tangential flow filtration, to a fully-automated high inoculation density (HID) production stage reactor. This reactor demonstrates substantial increases in bioreactor productivity compared to a low inoculation density control fed-batch process. Significant titer increases between LID and HID processes have been demonstrated with a panel of six CHOK1SV GS-KO® cell lines expressing three different monoclonal antibodies. In addition, increases in product concentration while maintaining comparable product quality were observed in process intensification for two cell lines expressing unique novel molecular formats: a monospecific ... Sponsored Content From Concept to Cleanroom: Case Studies in Single-Use Fluid Management CollaborationFrom Concept to Cleanroom: Case Studies in Single-Use Fluid Management Collaboration This webcast features: Gregory Verni, Vice President, Fluid Management, Scott Bendon, Senior Director of Engineering, Flow Control Technologies, Fluid Management, & Derek Masser, Director of Business and Market Development, Fluid Management, Repligen. Navigating the complexities of single-use bioprocessing involves managing numerous components, addressing inefficiencies, mitigating supply chain risks, and budget constraints. Your single-use partner should drive the innovation needed to overcome these challenges and transform ideas from the back of the napkin to your cleanroom floor, so you can focus on delivering life-changing therapeutics quickly and efficiently. This webinar analyzed three case studies, each highlighting different approaches to single-use collaboration. These real-world examples illustrate key considerations when working with single-use suppliers, helping you streamline your processes and prioritize what matters most. Key Takeaways: Register or Login and hit Watch on Demand to vie... See all White Papers Harmonization Graphic Sponsored Content Harmonizing Regulatory Guidelines for Assay Validation: A Focus on Kinetics-Based Assays Harmonizing Regulatory Guidelines for Assay Validation: A Focus on Kinetics-Based Assays Mettler Toledo WP Sponsored Content Elevate Single-Use Bioreactor Performance with Digital Single-Use pH Sensors Elevate Single-Use Bioreactor Performance with Digital Single-Use pH Sensors Thermo Fisher Plan for Success WP Sponsored Content Increase Efficiency and Reduce Costs in Bioprocessing: A Strategic Guide Increase Efficiency and Reduce Costs in Bioprocessing: A Strategic Guide View More Posters Accelerating Cell Line Development with an Efficient, Combined Platform Approach Sponsored Content Accelerating Cell Line Development with an Efficient, Combined Platform Approach Accelerating Cell Line Development with an Efficient, Combined Platform Approach Evaluation Of a New Glucose Control Strategy Using CITSens Bio APC (Automated Process Control) for CHO Fed-Batch Application Sponsored Content Evaluation Of a New Glucose Control Strategy Using CITSens Bio APC (Automated Process Control) for CHO Fed-Batch Application Evaluation Of a New Glucose Control Strategy Using CITSens Bio APC (Automated Process Control) for CHO Fed-Batch Application High Productivity and Process Economy in GxP Applications with the Octet™ Platform Sponsored Content High Productivity and Process Economy in GxP Applications with the Octet™ Platform High Productivity and Process Economy in GxP Applications with the Octet™ Platform View More Videos Sponsored Content Accelerating Process Development Through Rapid Aggregate Screening Accelerating Process Development Through Rapid Aggregate Screening View More BPI CONTENT BPI ArchiveBioProcess Insider NewsSubscribe to BioProcess Insider Newsletter RESOURCES EventsWebinarsWhite PapersPostersVideosPodcasts ABOUT BPI Who We AreEditorial AdvisorsAuthor GuidelinesAdvertising/Media KitList Rental/ReprintsCareers JOIN US Subscribe Subscribe FOLLOW US Copyright © 2024 Informa Connect Limited. 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