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November 01, 2022; 99 (18) In Focus
SPOTLIGHT ON THE NOVEMBER 1 ISSUE
José G. Merino
First published October 31, 2022, DOI:
https://doi.org/10.1212/WNL.0000000000201281
José G. Merino
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* Info & Disclosures
NOTABLE IN NEUROLOGY THIS WEEK
This issue features an article that investigates opiate-prescribing trends for
women with idiopathic intracranial hypertension; another determines gender
differences in headache care among US veterans in the Veterans Health
Administration. A featured Research Article examines the structure and
challenges of pediatric neurologic care delivery in North American academic
programs.
RESEARCH ARTICLES
PERCEPTION OF FRAGMENTED LETTERS BY PATIENTS WITH PATHOLOGICALLY CONFIRMED
DEMENTIA WITH LEWY BODIES OR ALZHEIMER DISEASE
In this study, the ability to identify visually degraded letters distinguished
patients with mild dementia due to autopsy-confirmed Lewy body disease (LBD) and
those with Alzheimer disease (AD) with 73% sensitivity and 87% specificity. It
was also negatively correlated with neocortical LBD pathology density. This
visuoperceptual task may aid in differential diagnosis of AD and dementia with
Lewy bodies.
Page 790
BEHAVIORAL AND COGNITIVE PHENOTYPES OF PATIENTS WITH AMYOTROPHIC LATERAL
SCLEROSIS CARRYING SOD1 VARIANTS
This study found neuropsychological changes in about 60% of patients with
amyotrophic lateral sclerosis (ALS). Patients harboring SOD1 variants, mainly in
exon 5, were more likely to have behavioral rather than cognitive impairment.
Behavioral involvement, which is independent from patients' age and disease
stage, can affect clinical trial outcomes and disease management.
Page 792
ASSOCIATION OF BLOOD BIOMARKERS OF INFLAMMATION WITH PENUMBRA CONSUMPTION AFTER
MECHANICAL THROMBECTOMY IN PATIENTS WITH ACUTE ISCHEMIC STROKE
This paper addresses the role of inflammation in the ischemic penumbra. Using
sequential assessment of blood biomarkers and MRI, the authors found that high
levels of soluble form suppression of tumorigenicity 2 were associated with a
high lesion growth within the penumbra. These findings could contribute to the
development of immunomodulatory therapies to salvage the penumbra.
Page 793
EARLY READMISSIONS AFTER HOSPITALIZATION FOR POSTERIOR REVERSIBLE ENCEPHALOPATHY
SYNDROME
In this large, retrospective cohort study, nearly one-third of patients
hospitalized because of posterior reversible encephalopathy syndrome (PRES) were
readmitted within 90 days of discharge and about one-third of these readmissions
were due to PRES-related or neurologic etiologies. A significant proportion of
patients with PRES may be at risk of symptom recurrence or other neurologic
sequelae after hospital discharge.
Page 794
* NB: “Frequency of New or Enlarging Lesions on MRI Outside of Clinical Attacks
in Patients With MOG-Antibody–Associated Disease,” p. 795. To check out other
Clinical/Scientific Notes, point your browser to Neurology.org. At the end of
the issue, check out a Resident & Fellow Section Clinical Reasoning article
discussing a woman with transient visual disturbances, and another on a
12-month-old boy with Baylisascaris procyonis. This week also includes a
Resident & Fellow Section Pearls & Oy-sters article titled “Genetic Epilepsy:
An Important Cause of Neonatal Seizures in Infants With Complex Congenital
Heart Disease.”
* © 2022 American Academy of Neurology
LETTERS: RAPID ONLINE CORRESPONDENCE
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Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X
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Spotlight on the November 1 Issue
José G. Merino
Neurology Nov 2022, 99 (18) 775-776; DOI: 10.1212/WNL.0000000000201281
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