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OCTOBER 5-9, 2025, SAINT-MALO, FRANCE


DYRK1A, RELATED KINASES AND HUMAN DISEASES CONFERENCE

Blue Tunicate (Rhophalaea sp.) & Strawberry Tunicate (Didemnum cf. moseleyi).
Bali, Indonesia. Copyright: Gary Bell/Oceanwideimages.com


GENERAL PRESENTATION

 * Dyrk1A related kinases and human diseases conference will focus on DYRK1A and
   related kinases, including structural, regulatory and functional aspects,
   substrates and interactors, functions at cell and organism levels as well as
   development and potential therapeutic use of selective pharmacological
   inhibitors in various indications.


ABOUT THE EVENT

 * DYRKs (‘dual specificity, tyrosine phosphorylation regulated kinases’)
   (DYRK1A, 1B, 2, 3, 4) play key roles in mRNA splicing, chromatin
   transcription, DNA damage repair, aging, cell survival, cell cycle,
   differentiation, endocytosis, neuronal development and functions, synaptic
   plasticity, mytochondrial functions. Inhibition of DYRKs may find
   applications in Down syndrome, Alzheimer’s disease and tauopathies,
   Parkinson’s disease, diabetes, myocardial infarction, otitis, osteoarthritis,
   viral infections, various cancers, etc. The closely related CLKs (‘cdc2-like
   kinases’) (CLK1, 2, 3, 4) also play essential functions in Alzheimer’s
   disease and tauopathies, alternative splicing, various viral infections,
   cancers, etc. DYRK and CLK orthologs are found in plants, fungi, yeast and
   unicellular parasites.

 * Contact us




ABSTRACT SUBMISSION


DEADLINE: JULY 31, 2025

 


DOWNLOAD THE TEMPLATE, DON’T TRY TO FILL IT ONLINE :

DYRK1A CONFERENCE ABSTRACT – SURNAME

You can download the PDF form by selecting “…” on the top right.


FILL IT, SAVE A COPY AND SEND :

When ready, send your PDF abstract with your surname in the title to : 
dyrk-conference@perha-pharma.com

LAYOUT INSTRUCTIONS : 

Title and authors:

 * 1 page maximum written in English
 * Arial 11
 * Title in Bold
 * Underline presenting author
 * Add your contact information: e-mail, address

Abstract:

 * Line Spacing 1
 * maximum 2500 to 3000 characters (with spaces)
 * References: maximum 800 characters (with spaces): 1 to 3 compact references
 * Funding: maximum 350 characters (with spaces)

When ready send your abstract to our e-mail address:
dyrk-conference@perha-pharma.com


INVITED SPEAKERS

Contact: dyrk-conference@perha-pharma.com

WALTER BECKER, AACHEN, GERMANY

DYRK1B, a cancer drug target

MARCO CALZADO CANALE, CORDOBA, SPAIN

DYRK2 as a novel modulator of cancer pathways

JOHN CRISPINO, MEMPHIS, USA

Amplification of DYRK1A drives transformation to acute leukemia

MARA DIERSSEN, BARCELONA, SPAIN

Role of DYRK1A in glucose homeostasis and food intake

CRISTINA FILLAT, BARCELONA, SPAIN

Role of DYRK1A in pancreatic cancer tumor microenvironment

MARIA GAITANOU, ATHENS, GREECE

DYRK1B in motor neuron development in health and disease

YANN HERAULT, STRASBOURG, FRANCE

Lessons learnt from studying DYRK1A in mammalian models for MRD7 and Down
syndrome

CHRISTOPHER HULME, TUCSON, USA

The development of an ultra-selective DYRK1A PROTAC, DYR684

MATTIAS LAUTH, MARBURG, GERMANY

DYRK1B in pancreatic cancer

MATTIAS LINDBERG, ROSCOFF, FRANCE

Affinity chromatography purification of DYRK1A and associated proteins

LARISA LITOVCHICK, RICHMOND, USA

Understanding the multifunctional DYRK1A kinase through characterization of its
interacting proteins

ARYA MANI, YALE NEW HAVEN, USA

DYRK1B regulates beta cell function and structure by orchestrating microtubule
assembly and ciliary structure

LAURENT MEIJER, ROSCOFF, FRANCE

Phase 1 clinical evaluation of the DYRK1A inhibitor Leucettinib-21

JAMILEH MOVASSAT, PARIS, FRANCE

DYRK1A inhibitors for beta cell proliferation to treat diabetes

DEAN NIZETIC, LONDON, U.K

Dose imbalance of DYRK1A is a causative factor for the developmental progeria in
Down syndrome

AMÉLIE PITON, ILLKIRCH, FRANCE

Characterization of DYRK1A syndrome, a frequent form of neurodevelopmental
disorder

VICTOR TYBULEWICZ, LONDON, U.K.

Increased dosage of DYRK1A is required for congenital heart defects and many
other pathological phenotypes in Down syndrome

NORA VÖGTLE, UNIVERSITY OF HEIDELBERG, GERMANY

News from the DYRK1A – mitochondria axis

MATTHEW WOLF, CHARLOTTESVILLE, USA

The inhibition of DYRK1A improves cardiac function after myocardial infarction


INSTRUCTIONS FOR SPEAKERS

There will be no poster sessions. We will try to have as many people as
possible, especially students and post-docs, presenting their results. Besides
invited speakers, submitted abstracts will be selected for long (15 min) or
short (5 min) oral presentations (+ 5 min discussion).


REGISTRATION

Saint-Malo, walled city


KEY DATES

Abstracts deadline : July, 31st, 2025

Early bird registration deadline : April 30th, 2025

Latest registration deadline : August 31st, 2025

Onsite registration : October 5th, 2025 at 3:00 pm

Plenary Session : October 5th, 2025 at 6:30 pm

Start of the conference : October 6th, 2025 at 9:00 pm

End of the conference : October 9th, 2025 at 12:00 pm

Excursion to the Mont-Saint-Michel : October 9th, 2025 from 1:30 pm to 7:00 pm
(upon registration)

Fort National, Saint-Malo


REGISTRATION COSTS & PAYMENT INFORMATION

PLEASE DOWNLOAD THE REGISTRATION FORM :

Registration form Dyrks conference 2025

Don’t try to fill it online. You can download the PDF form by selecting “…” on
the top right.

FILL IT AND SEND IT BACK BY MAIL. THERE IS NO ONLINE PAYMENT.

DYRK-CONFERENCE@PERHA-PHARMA.COM

Registration includes access to all conferences, program, welcome cocktail,
coffee/tea breaks and lunches. 

Early bird registration costs

PhD Students* : 450 €
Academic and Start-up : 750 €
Industry : 900 €

Late registration costs

PhD Students* : 550 €
Academic and Start-up : 850 €
Industry : 1200 € 

* Photocopy of student card required

Optional excursion :   60 € /pers. 
Excursion is subject to prior registration and payment (during your on-line
registration). More information will be available soon.


PROGRAM AND BOOK OF ABSTRACTS

 

The final program will be available in September 2025.

October 5th, 2025 at 3:00 pm :  Opening of registrations and welcome cocktail at
Le Palais du Grand Large, Saint-Malo

A book of abstracts will be offered to the participants at registration

October 6th, 7th and 8th, 9:00 am to 7:00 pm : schedule of the sessions to be
determined

October 9th, 9:00 am to 12:00 pm : schedule of the sessions to be determined

October 9th, 1:30 pm to 7:00 pm : Excursion to the Mont-Saint-Michel and its
Abbey




EXCURSION TO THE MONT-SAINT-MICHEL AND ITS ABBEY

In the afternoon of October 9th we organize an excursion to the
Mont-Saint-Michel and its Abbey. Excursion is subject to prior registration and
payment (during your on-line registration).

Cost is 60 € per person.

If you are interested in participating, tick the box in the abstract template or
simply send us an e-mail before June 6th, 2025. 

Visit schedule :
1:30 pm :  Departure in bus from Saint-Malo
2:30 pm : Guided visit of the Mount and Abbey
5:45 pm : Return to the bus
6:00 pm : Bus departure 
7:00 pm : Arrival in Saint-Malo


PREVIOUS DYRK1A CONFERENCES



VISIT OUR COMPANY WEBSITE : PERHA PHARMACEUTICALS CONFERENCES

TO READ THE BOOKS OF ABSTRACTS OF 2017 AND 2022

DYRK1A RELATED KINASES AND HUMAN DISEASES CONFERENCES

HAVE A LOOK AT THE


EVENT SCHEDULE


VENUE


CONFERENCE CENTRE

Palais du Grand Large
Centre des congrès, Saint-Malo
1 Quai Duguay-Trouin
35 400 Saint-Malo
https://www.pgl-congres.com/

 * TGV in 2h15 from Paris
 * The TGV train station is 5min away by bus 20min on foot
 * Rennes airport at 50 min
 * 1160 parking places around the Palais
 * 1 hour from Rennes by car, 2 hours from Nantes and 4 hours from Paris


ACCOMODATION

Le Palais du Grand Large in Saint Malo proposes a list of Hotels. 


SAINT-MALO & BRITTANY

Tourism office : www.saint-malo-tourisme.com
St Malo city hall : www.ville-saint-malo.fr




THANK YOU FOR YOUR PARTICIPATION TO THE DYRK1A CONFERENCE IN 2022




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