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NMN Powder -100 Grams – RENUE BY SCIENCE Skip to content
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NAD Precursors
NMN POWDER -100 GRAMS
$89.05
100 grams Pure Crystalline NMN Powder is designed for sublingual (under the
tongue) use for superior bioavailability.
SERVINGS
200 Per Jar
500 MG
Per Serving
SUBLINGUAL
Under the Tongue
SERVINGS
200 Per Jar
500 MG
Per Serving
NMN Powder -100 Grams quantity
Add to cart
* Description
* Additional information
* Testing
* Sublingual Delivery
* FAQ
NAD+ products have very poor bioavailability unless a delivery method is used
that can protect the ingredient from digestion. When taken in regular capsules,
less than 10% of NMN or NR make it to the bloodstream intact.
To address this problem, in 2016 we pioneered Sublingual delivery of NMN, and
since then have advanced the industry further with Intranasal, Transdermal, and
Liposomal NMN products.
Here we compare each of these, highlighting their unique strengths to help you
decide which product is right for you. See all products here.
* These assessments are relative. For example, ALL our products provide much
greater bioavailability than standard capsules (which we do not offer), but we
highlight liposomal delivery as it is more bioavailable than sublingual. All
forms get a checkmark for "Improved energy" as they are nearly equal.
Convenience/Portability - This is ideal for those who want the ability to take
NMN with them throughout the day. Our sublingual tablets, LIPO capsules, and
nasal spray are ideal for those who are on the go and who like to take NMN at
different intervals throughout the day.
Fast Acting - If fast acting is important to you, then we recommend our
sublingual powder, tablets, or nasal spray as they bypass digestion. They can
provide rapid absorption and reach systemic circulation for a noticable effect
in minutes. So whether it's before a quick workout or you need to quickly focus
on mental tasks, these products can give you a quick boost when you need it
most.
Long Lasting - LIPO NMN lasts longer in the body than our other NMN products.
Liposomes protect the active ingredients from digestion and release slowly in
the bloodstream up to 24 hours.
Fastest Cognitive Effect- The sublingual powder has a very fast effect on
physical energy, but the intranasal spray has a much stronger impact on improved
cognition (the relief of "brain fog").
Improved Energy- Sublingual delivery is much faster acting and the energy boost
is more quickly noticed, but the most common report from users of all NAD+
boosters is increased energy.
Easiest to Take - Some people have trouble swallowing pills or applying powder
under the tongue. For those people, LSG NMN is easier because it comes in an
easy to apply liquid gel.
Best Bioavailability - Approximately 30% of NMN taken sublingually gets absorbed
directly into the bloodstream, while the rest passes through the GI tract and
gets broken down into less effective nicotinamide. However liposomal delivery
avoids degradation in the GI tract entirely, meaning far more NMN is delivered
to the tissues intact.
Best Cost per Milligram - The NMN product with the best price is our sublingual
powder as there is very little added cost for processing. Tablets are next.
Manufacturing of Liposomes takes the most time and expensive machinery, so cost
the most per Milligram.
Best Overall Value - The best overall value is the product which is best in
price combined with best bioavailability. Bioavailability is how much of the
product actually makes it to the cells intact. For example, our LIPO capsules
cost more per milligram to manufacture, but are 3 to 5 times more bioavailable
than sublingual products, so are much more cost effective.
See all products here.
These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
NAD Product Types
Sublingual
TESTING
SUBLINGUAL DELIVERY
Sublingual (under the tongue) delivery can provide rapid absorption via the
blood vessels under the tongue rather than via the digestive tract. (1,2,3)
The absorption of the different molecules delivered through the sublingual route
can be 3 to 10 times greater than oral route and is only surpassed by liposomal
delivery and direct IV injection (3).
Research on sublingual delivery of NMN specifically, is not yet published, so
the increased efficiency is not yet quantified.
RESEARCH SHOWS NMN & NR DIGESTED TO NAM
This research published in 2018 confirms that most oral supplements of NMN and
NR are digested to NAM in the GI tract or the liver.
"Unlike in cell culture where NR and NMN are readily incorporated into NAD, oral
administration fails to deliver NR or NMN to tissues." (R)
"Interestingly, we found that neither compound was able to enter the circulation
intact in substantial quantities when delivered orally." (R)
SUBLINGUAL CAN BE MORE BIOAVAILABLE THAN IP INJECTION
With intraperitoneal injection, the primary route of absorption is via the
mesenteric vessels, which drain into the portal vein and pass through the liver
before reaching the bloodstream.
This means, IP avoids the GI tract, but is still sent directly to the Liver,
where much of it is converted to NAD+. Elevated NAD+ in the liver is good, but
its far better to reach the bloodstream with intact NMN.
Sublingual delivery is not filtered by the Liver and can reach systemic
circulation intact, so can actually result in greater bioavailability that
direct injection. Some examples are:
* * A sublingual formulation of zolmitriptan exhibited a faster rate of
absorption and higher drug exposure as compared to subcutaneous injection
(4)
* sublingually administered epinephrine results in more rapid absorption and
a higher peak plasma concentration compared to injected
* epinephrine (4)
* 40mg of sublingually administered piroxicam was found to be as effective as
a 75 mg intramuscular injection of diclofenac (4)
NAD+ METABOLISM IN HUMANS
NAD+ can be synthesized in humans from several different molecules (precursors),
through the De Novo and Salvage Pathways.
The salvage pathway sustains 85% or more of our NAD+ (14), with approximately 3g
of NAM metabolized to NMN and then to NAD 2-4 times per day (14).
Nampt is the rate-limiting step in the salvage process. As you age, Nampt enzyme
activity is lower, resulting in less NAM recycling, less NAD+, more disease and
aging.
SUBLINGUAL NAD+ BYPASSES THE NAMPT BOTTLENECK
Restoring NAD+ in the Liver does not solve NAD+ deficiency throughout the body.
In the Liver, the CD38 enzyme metabolizes NAD+ to NAM, which is excreted to the
rest of the body (6).
Sublingual delivery of NMN or NAD+ directly to the bloodstream partially
bypasses the liver and the Nampt bottleneck.
FAQ
NMN FAQ
Where do you source your NMN from?
We purchase the raw ingredients from four different suppliers, that are all in
China.
EVERY brand of NMN purchases the raw ingredients from China. That’s the same
with most other vitamins and supplements.
Safety and purity are our top priority and we have implemented stringent and
rigorous testing procedures to ensure this. We test every batch upon receipt in
the US and process further. We then test every batch of finished product, and
post the results on our website with batch number so customers can verify that
the finished product they purchase was in fact tested, not just a sample of a
raw ingredient that may or may not have made it into the finished product.
We are the ONLY brand that tests finished products and posts results with the
BATCH NUMBER on our website.
Ours is processed, tested, and packaged in the USA. Almost all vitamins and
supplements you buy use raw ingredients that originate in China but are tested
and packaged in the USA to ensure safety.
How do you ensure the purity of your sourced NMN?
We test every batch of NMN in the US before processing it.
You can see the test results on the product page, underneath the "Testing" tab.
You can find the batch number of your item to verify that the finished product
was tested.
We are the only brand that tests finished product and posts results with the
batch number on our website.
All of our products are processed, tested, and packaged in the United States.
Is there any proof of NMN's benefits?
There are dozens of studies showing extremely promising results in mice, such as
greatly increased endurance, new blood vessel growth, glucose tolerance, and
much more.
In humans, there have been 12 NMN studies to date. Click here for summaries of
the studies and links to the full research papers.
There are also countless numbers of personal stories and testimonials. Join
our /Renue subreddit to connect with others, ask questions in the community and
learn about the experiences people are having with these supplements.
Do I need to take TMG with NMN?
In certain cases, taking NAD+ boosting supplements can deplete levels of methyl
groups in the body.
TMG is one of the most important ways to restore methyl groups because as the
name implies, it has three methyl groups to donate as NAD+ gets used, it is
broken down into Nicotinamide (NAM).
To get rid of excess NAM, a “methyl” is attached to NAM to form
methylnicotinamide (MeNAM) so it can be excreted.
Consequently the more NAD+ that is used, more MeNAM needs to be excreted which
can put a stress on the pool of methyl groups, leaving less for other essential
methylation functions.
There is no research that says normal dosages (less that 1,000mg) of NMN or NR
deplete methyls and require TMG.
However, several doctors have recommended it, and many people prefer to take it
alongside NMN or NR, just as an insurance policy.
In addition, TMG has a whole range of other potential benefits. We now offer TMG
as part of our product line.
What age should I start taking NMN?
NAD+ levels decline with age after around 25 years old. The goal of taking NAD+
precursors like NMN is to boost your levels back to what they were when you were
younger. But age isn't the only thing that causes NAD+ to decline - for example,
stress, inflammation, environmental toxins, lack of sleep. Therefore, NMN is
safe to take at any age. An NAD+ blood test is the only way to confirm if your
levels are suboptimal, but it cannot hurt to take NMN even if you're still
young.
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Sublingual Delivery FAQ
How do you take the sublingual NMN?
For pure powder NMN sublingually, scoop the NMN into your mouth and hold it
under your tongue.
If you're taking a tablet, hold it under the tongue.
If you're using a liposomal gel product, you can squeeze it into your mouth and
hold under your tongue as well.
Try to keep the products under your tongue for 30-45 seconds.
If you swallow it sooner, the liposomes will still offer protection through the
stomach and it will be absorbed through the intestine into your bloodstream.
How does sublingual delivery work?
Sublingual delivery (under the tongue) provides rapid absorption through the
blood vessels under the tongue rather than through the digestive tract.
The absorption of molecules delivered through the sublingual route is greater
than oral route and is only surpassed by liposomal delivery or by direct IV
injection.
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These products are not intended to diagnose, treat, cure or prevent any disease.
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These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
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