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 * What we do
   * Purpose
   * Hallmarks of aging
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WE MAKE THERAPIES HAPPEN - TO HELP PEOPLE AGE BETTER, AND LIVE LONGER



We are a team of experienced drug discovery and development experts driven by
curiosity into humanity’s oldest problem: aging

Who we are



WORK WITH US


Partner with us to make your therapies happen



OPEN POSITIONS


Join our team
and make your future


Rejuveron is building a pipeline with breakthrough therapeutics along the
hallmarks of aging

What we do

GENOMIC INSTABILITY

primary hallmark

As cells age, their chromosomes become less stable and their DNA accumulates
damage and mutation. DNA repair mechanisms also start to fail which leads to
more mutations and promotes aging and disease.

SENESCENCE

antagonistic hallmark

Senescent cells are cells that should have died and been destroyed, as part of
normal turnover, but instead stay alive and start making many proteins that
negatively affect other cells in their surrounding (so called “zombie cells”),
causing multiple associated diseases. As we age, we accumulate senescent cells,
something we wish to prevent.

TELOMERE ATTRITION

primary hallmark

Telomere is the name given to the ends of each of our chromosomes, which are
made of our DNA. As cells divide, telomeres get shorter until they become too
short, causing our cells to age and stop functioning properly.

DEREGULATED NUTRIENT SENSING

antagonistic hallmark

High metabolic activity can put stress on our cells and cause them to age.
However, when cells have limited nutrients available, they enter a regenerative
mode, a state which has been shown to increase lifespan in mice. Mimicking this
process with small molecules has the potential to increase health- and lifespan
in humans too.

MITOCHONDRIAL DYSFUNCTION

antagonistic hallmark

Mitochondria are the powerhouse of cells, as they use nutrients to make energy
for us to live. However, with age, they build-up oxidative stress, mutations,
and lose their integrity, which lead to cellular dysfunction and aging.

STEM CELL EXHAUSTION

integrative hallmark

With age, stem cells lose the ability to differentiate and replace cells
throughout the body. This is particularly important in the bone marrow where
stem cells give rise to blood and immune cells and where exhaustion of stem
cells leads to a weak immune system, making the aged population particularly
vulnerable to infection.

EPIGENETIC ALTERATIONS

primary hallmark

As cells are exposed to environmental factors, their DNA is subtly modified
through epigenetic mechanisms. These changes accumulate over time, promoting
alteration of gene expression which underlies several aging-related diseases.

LOSS OF PROTEOSTASIS

primary hallmark

Our cells are constantly renewing proteins by degrading old proteins and making
new ones. When these autophagic processes starts to fail, damaged and misfolded
proteins accumulate in cells, leading to cellular death and aging.

ALTERED INTERCELLULAR COMMUNICATION

integrative hallmark

As cells age, they show an increase in self-preserving signals as opposed to
adequate chemical communication with their neighbors. For example, aged cells
that become senescent will trigger chronic low-grade inflammation (so
called-inflammaging) which contributes greatly to the aging process.

Endogena
Therapeutics

Discovering and developing endogenous regenerative medicines that repair tissues
and organs




Rejuveron Senescence
Therapeutics

Identifying novel ways of targeting senescent cells to produce therapies that
will improve health in old age




Rejuveron Vascular
Therapeutics

Restoring the aging vasculature of the brain to improve its function and prevent
devastating conditions




Rejuveron Telomere
Therapeutics

Developing ways of promoting healthy aging by improving telomere function




Rejuvenate
Biomed

Translating the science of keeping cells vital and resilient into human
therapeutics to increase the healthy years of life




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