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JOURNAL ARTICLE




SYSTEMIC LUPUS ERYTHEMATOSUS: A CLINICAL UPDATE

Kathryn Connelly, Eric F Morand
Internal Medicine Journal 2021, 51 (8): 1219-1228

34423550
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease known
for its complexity and heterogeneity. Striking diversity can be observed between
individual patients, in terms of clinical manifestations, serological
abnormalities, disease progression and response to therapy. Furthermore,
dysfunction of a broad range of immune pathways underlies disease development
and expression. An appreciation of this diversity is vital in order to diagnose
accurately and appropriately treat patients with SLE as there is no
one-size-fits-all diagnostic test or treatment. Optimal management involves
identifying affected organs, assessing severity, differentiating activity from
irreversible damage and tailoring immunosuppressive treatment accordingly.
Non-pharmacological interventions, attention to disease and treatment-related
comorbidities and addressing the significant impact on health-related quality of
life are also crucial to maximising patient outcomes.

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