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BREAKTHROUGHS AND BREAKING NEWS


CARDIAC ARREST: HISPANICS, LATINOS WITH KIDNEY DISEASE AT HIGH RISK

Hispanics and Latinos with chronic kidney disease are at significant risk for
suffering from sudden cardiac arrest, according to a new study from the Smidt
Heart Institute at Cedars-Sinai. During sudden cardiac arrest, the heart
unexpectedly stops beating. “Because people who experience sudden cardiac arrest
have a survival rate of less than 10%, prevention is extremely important,” said
Kyndaron Reinier, PhD, associate director of Epidemiology in the Center for
Cardiac Arrest Prevention at the Smidt Heart Institute and lead author of the
study published in the Journal of the American Heart Association. “This study
highlights the importance for Hispanic and Latino individuals with chronic
kidney disease to understand their risk of sudden cardiac arrest, and to closely
monitor and manage their renal disease with their medical care team.” The study
also reports that Hispanics and Latinos with cardiovascular disease have an
increased risk of sudden cardiac arrest. The research was conducted as part of
an ongoing study called the Prediction of Sudden Death in Multi-Ethnic
Communities (PRESTO) that is led by Sumeet Chugh, MD, director of the Center for
Cardiac Arrest Prevention in the Smidt Heart Institute. Investigators involved
are gathering data on people in Ventura County, California, who experience
sudden cardiac arrest. The goal is to learn about possible causes for this
often-fatal event. In this study, investigators reviewed information from 1,468
adults in Ventura County who had sudden cardiac arrest between 2015 and 2021.
From this cohort, they extracted data from 295 people who were Hispanic or
Latino. To create a comparison group, investigators looked at data from 3,033
Hispanic and Latino adults who participated in the San Diego site of a study
called the Hispanic Community Health Survey/Study of Latinos. Participants in
the Hispanic Community Health Survey study completed one medical examination
between 2008 and 2011 and another between 2014 and 2017. Investigators selected
590 people from this cohort to compare with the group that had experienced
sudden cardiac arrest. The investigators took into account age, sex, and other
variables when comparing people who suffered sudden cardiac arrest with those
who did not. They found that people who suffered sudden cardiac arrest were more
likely than people who did not suffer sudden cardiac arrest to have had chronic
kidney disease, a stroke, atrial fibrillation, coronary artery disease, heart
failure, diabetes or to have been heavy drinkers. Of the people who had sudden
cardiac arrest, 51% had a prior diagnosis of chronic kidney disease, and 20%
were on dialysis at the time of the event. “This study is the first we know of
to analyze risk factors for sudden cardiac arrest among U.S. Hispanic and Latino
individuals,” said Chugh, the Pauline and Harold Price Chair in Cardiac
Electrophysiology Research and senior author of the study. Reinier said she
hopes the findings spur research into the connection between chronic kidney
disease and sudden cardiac arrest. Cedars-Sinai investigators Harpriya Chugh;
Arayik Sargsyan, MD; Kotoka Nakamura, PhD; Faye Norby, PhD; and Audrey
Uy-Evanado, MD, also worked on the study. Funding: The PRESTO study was funded,
in part, by the National Heart, Lung, and Blood Institute. The Hispanic
Community Health Survey/Study of Latinos study was supported by the National
Heart, Lung, and Blood Institute; National Institute on Minority Health and
Health Disparities; National Institute on Deafness and Other Communication
Disorders; National Institute of Dental and Craniofacial Research; National
Institute of Diabetes and Digestive and Kidney Disease; National Institute of
Neurological Disorders and Stroke; and the Office of Dietary Supplements. Read
more on the Cedars-Sinai Blog: New Research on Sudden Cardiac Arrest Shows
Racial Gap



CEDARS-SINAI EXPANDS VIRTUAL HEALTHCARE FOR CALIFORNIA PATIENTS

Cedars-Sinai is expanding virtual healthcare for patients in California through
a new mobile app that allows individuals to quickly and easily access
Cedars-Sinai experts for sick, chronic, and preventive care. Through the new
virtual healthcare option Cedars-Sinai Connect, healthcare professionals are
available 24/7 for urgent issues, and same-day appointments are accessible for
primary care—reducing wait times for those seeking medical attention.
“Cedars-Sinai Connect is a natural extension of the high-quality care
Cedars-Sinai already provides to patients in person,” said Jill Martin,
executive vice president of Cedars-Sinai Medical Network. “What could be more
convenient than getting the care you need when you need it—in the palm of your
hand—in your home or office?” The new mobile app harnesses AI technology
developed by K Health that empowers physicians by reducing the burdens of
clinical intake and data entry, allowing doctors to focus more on patient care.
K Health helps patients manage their acute, chronic and preventive care needs
through a platform that harnesses medical knowledge and real patient
experiences. K Health and Cedars-Sinai developed Cedars-Sinai Connect through a
new joint venture. The partnership gives new and existing patients expanded
treatment options for a broad range of medical conditions from a dedicated team
of virtual care providers. The app’s chat feature gathers health details and
symptoms from patients to help assess their medical concerns and  presents that
information to a clinician for review. This streamlines the intake process so
providers can focus more on patient care. After the guided intake, patients can
choose to connect with a clinician for an appointment via video call.
Cedars-Sinai Connect will accept all forms of insurance that Cedars-Sinai takes,
including employer-provided plans. “Patient care plans and visit information are
integrated into the Cedars-Sinai health record, making it easy for patients to
move between online and in-person care in a coordinated way, and for patients to
access our broader network of specialists when needed,” said Caroline Goldzweig,
MD, chief medical officer of Cedars-Sinai Medical Network. “This new platform
will help us expand and enhance care for patients across California.” K Health’s
founders said the partnership with Cedars-Sinai will give patients greater
access to world-class medical expertise, empowering people to take charge of
their health by choosing when and where they get care. “We’re excited to work
with Cedars-Sinai, an esteemed institution that shares our vision to provide
people with unfettered access to exceptional medical care around the clock,”
said Ran Shaul, the company’s co-founder and chief product officer. “By fusing K
Health’s technology with Cedars-Sinai’s renowned care, we are advancing primary
care delivery by extending essential services to a wider spectrum of people in
need while alleviating physician burnout.” Read more on the Cedars-Sinai Blog:
Virtual Second Opinion | Here’s What to Know



BREAST CANCER AT 30?

Amanda Butler and Isabella Bugatti, both just entering their 30s, were
blindsided by a diagnosis that is on the rise among women their age: breast
cancer. They are not the only ones. A recent study in the peer-reviewed journal
JAMA Network Open found that although most cancer in the U.S. occurs in people
age 65 and older, cancer—especially breast, endocrine and gastrointestinal
cancer—is on the rise in younger patients. The study also found that between
2010 and 2019, breast cancer rates significantly increased in women under age
40. “We’ve had a surge of young patients, Amanda and Isabella among them,” said
Yuan Yuan, MD, PhD, director of Breast Medical Oncology at Cedars-Sinai Cancer,
who is treating both women. “Fortunately, even in the aggressive forms these
young women have, breast cancer is a treatable, and often curable, disease.”
Butler, a fitness trainer from West Hollywood, was 32 when she felt a lump in
her right breast about a year ago. She was diagnosed with triple-positive breast
cancer, a form fueled by the hormones estrogen and progesterone, and a protein
called HER2. She also tested positive for a BRCA2 genetic mutation. “No one in
my family had had breast cancer,” Butler said. “The diagnosis was a shock to me
because I was the healthiest person I knew. I care so much about my health. I
work in fitness and wellness.” Bugatti, born at Cedars-Sinai and raised in Los
Angeles, has worked in politics—all over the country, and most recently, in
Washington, D.C. In May, the 30-year-old was in her Washington apartment
chatting with a friend when she sat back, crossed her arms, and felt a lump in
her left breast. Her doctor referred her for a mammogram and an ultrasound. She
was diagnosed with bilateral triple-negative breast cancer, and she moved back
to L.A. for treatment. This diagnosis has taught Bugatti the importance of
advocating for your own health. Although this fast-spreading, aggressive cancer
type is more common in young women, it still only accounts for 10%-20% of all
breast cancers. And because it lacks receptors for estrogen, progesterone, and
the HER2 protein, it can be tricky to treat. Despite some family history,
Bugatti was unaware that she had a BRCA1 gene mutation. “Breast cancer was not
even on my radar,” Bugatti said. “My maternal grandmother had breast cancer, but
my mom did genetic testing a couple of years ago and was negative for BRCA
mutations, so we thought I couldn’t possibly be positive. It was a complete,
complete shock. I never thought I could inherit this gene from my father’s
side.” Inheriting a BRCA1 or BRCA2 mutation comes with a 45% to 85% lifetime
risk of developing breast cancer, and the mutation also increases risk of
developing ovarian and several other types of cancer. Yuan urged women to seek
out genetic testing if they have a first-degree relative—a mother, father,
brother, sister or child—with a breast cancer diagnosis or a BRCA1 or BRCA2
mutation. “Beyond that, young women are their own best road to early diagnosis,”
Yuan said. “Mammograms work well for women ages 40 and up, but younger women’s
dense breast tissue can hide small tumors. Young women who feel a lump in their
breasts should seek medical attention and a diagnostic mammogram immediately,
with a follow-up ultrasound if the mammogram is inconclusive.” After
chemotherapy to help shrink her tumor, Butler had a double mastectomy and
radiation therapy in May. She will continue on low-dose chemotherapy to target
any residual cancer cells until March. She is also enrolled in a clinical trial
of a combination therapy to help prevent cancer recurrence. Butler also founded
a cancer support group and published an e-book about what to expect when
undergoing chemotherapy. She is slowly resuming her work in fitness, and credits
cancer with helping her face some deep-seated fears. “Because of my diagnosis,
I’ve faced the worst and I’ve seen the worst, and all of the things that I was
worried about, I’ve dealt with,” she said. Bugatti is finishing a course of
immunotherapy plus chemotherapy—a major recent advance in treating
triple-negative breast cancer—and then will have a brief break before her double
mastectomy. While still on leave from work, she said she has been feeling well
enough to do some hiking and try a few new hobbies. “I’m in a much better space
mentally now than when I was first diagnosed. Meeting with my amazing oncology
team at Cedars and putting together a treatment plan helped me see that a life
after cancer was possible,” Bugatti said. “My tumors are now undetectable on an
ultrasound, and I’m truly just focused on making sure that I stay healthy, and
on doing the things that make me happy.” Learn more on the Cedars-Sinai Blog:
Cancer Prognosticator



EARLY DIAGNOSIS OF AUTISM AND ADHD

Autism and ADHD rates are skyrocketing as awareness grows, but many children
still slip through the cracks. Early diagnosis is vital to their development.



SEEING PINK: AWARENESS RIBBONS A TROUBLING REMINDER TO SOME

For some breast cancer patients, survivors and loved ones, pink ribbons may act
as an emotional trigger.




BENCH TO BEDSIDE EXCELLENCE


RESEARCH

Our leaders in translational and basic science research advance the world's
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