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OPINION

WHEN TREATING TRANSGENDER YOUTH, HOW INFORMED IS INFORMED CONSENT?

By Megan McArdle
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March 8, 2024 at 7:45 a.m. EST

Prescription hormone therapy drugs. (Whitney Curtis for The Washington Post)

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In the debate over transgender medicine for youths, two radically opposing views
take up most of the airtime. People who support the currently dominant
gender-affirming model of care for children see kind practitioners trying to do
their best for vulnerable patients who often have severe mental health issues
due to living in a transphobic society.



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Those who oppose this model see overconfident practitioners experimenting on
these same vulnerable patients, many of whom might not be capable of giving
truly informed consent for treatments such as puberty blockers, cross-sex
hormones and surgeries, which can have lifelong consequences.

Both views will find vindication in a new report from the think tank
Environmental Progress, which contains a leaked cache of internal discussions
from within WPATH, the World Professional Association for Transgender Health, a
group that brings together clinicians from various specialties involved in
treating gender-dysphoric patients. These discussions reveal both caring people
trying hard to do things right and a medical culture that appears to be
operating without adequate guardrails against things going wrong.

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One exchange is at once the most reassuring and the most worrying for those who
are trying to sort out the competing narratives: In a workshop discussing
transition and the challenge of obtaining minors’ informed consent for
gender-affirming procedures, participants come across as deeply thoughtful folks
doing their best to grapple with complexities. But some also seem to acknowledge
that their patients cannot actually give fully informed consent. Many haven’t
completed puberty — or high school biology. And even the brightest 16-year-old
cannot yet understand the full implications of treatments that can mean, in some
cases, a lifetime of infertility and medical maintenance.

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This is not a novel problem in medicine. As therapist Dianne Berg points out in
that discussion, if children have diabetes, they are given insulin even if they
haven’t learned how the pancreas works. If they have depression, they might be
given drugs that could increase their risk of suicide or permanently alter their
developing brains to help them toward happier futures. And if a kid has a
pediatric cancer, doctors don’t wait for her to be old enough to give fully
informed consent to amputation or infertility — because without treatment, she
might never reach that age.

Youth gender medicine is increasingly treating puberty as though it were a
life-threatening condition like cancer or diabetes, and natal sex organs as
though they were potentially dangerous growths. This is, of course, entirely
appropriate if they are threatening, and letting nature take its course will end
in suicide or a lifetime of emotional agony. Of course, with that kind of
diagnosis you want to be very sure — and unlike doctors treating cancer or
diabetes, who can rely on blood tests and imaging, gender-medicine doctors
ultimately have only the patient’s feelings to go by.

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In the popular discourse, and apparently at some gender clinics, it’s often
taken for granted that that’s enough — that we know transgender medical
interventions are saving lives, because trans people are at higher risk for
suicide. And for adults, who are entitled to decide what to do with their
bodies, it is. Yet for children, it’s more complicated, because this risk, while
real, does not approach the magnitude of cancer or diabetes, and might persist
even after treatment. In a large-scale Dutch study, trans patients were found to
have almost four times the suicide risk of the general population. The
researchers saw 49 suicides among more than 8,000 patients, many of which
occurred during or after transition. A nationwide study of suicide rates among
trans people in Denmark similarly found 12 suicides in a population of 3,759.

It would be ideal if doctors could drive that rate to zero — perhaps by
identifying future trans adults, blocking their puberty and eventually treating
them with hormones and possibly surgery so that their adult appearance would
more closely resemble their gender identity. Unfortunately, though, we don’t yet
know to what extent these treatments actually improve mental health or prevent
suicide. The data on their long-term efficacy is more limited than it should be,
even for adults. The evidence regarding youth interventions is even less clear.

Several European health authorities have reviewed the available studies and
rated the evidence for using puberty blockers and cross-sex hormones in
dysphoric youth as “very low certainty,” “deficient” and “limited by
methodological weaknesses.” A recent systematic evidence review by German
researchers concludes that the current body of evidence is “based on very few
studies with small samples and problematic methodology and quality. Adequate and
meaningful long-term studies are equally lacking.”

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In other words, though WPATH says these interventions are “not experimental,”
youth gender medicine is still, well, effectively experimental. Now, this is
true, as well, of many pediatric oncology treatments, because when a child’s
life is in danger, doctors pull out all the stops. About 60 percent of juvenile
cancer patients are enrolled in a clinical trial, according to CureSearch, a
funder of children’s cancer research. But gender medicine does not yet approach
the same level of rigor as an FDA-supervised clinical trial.



This puts clinicians in a difficult position, and this is what we see in the
WPATH files: well-intentioned doctors and therapists groping through the
considerable gaps in current medical knowledge. Yet one can also see this work
being made more difficult because, as an editorial in the journal Acta
Paediatrica recently put it: “The discourse surrounding the use of puberty
blockers in gender dysphoria is often framed as a political human rights issue
rather than as a medical issue.”

In a discussion of detransitioning, one writer calls the whole idea
“problematic” because “it frames being cisgender as the default, and reinforces
transness as a pathology.” (As though it were inherently bigoted for someone to
prefer, where possible, the option that doesn’t require drugs or surgery.)
Others rather blithely suggest we should reframe detransition as “learning” or
part of a “gender journey” rather than a “mistake.”

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Many other conversations in the WPATH files, of course, portray sensitive,
intelligent caregivers doing their best — beset by many uncertainties, yet
ultimately in little doubt that they’re doing the right thing for most of their
patients. I’m glad such people are trying to help some of our vulnerable people
alleviate terrible distress. But I also came away wishing they seemed willing to
entertain a few more doubts.

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