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Nature Rev. Cancer 18, 433–441 (2018). Article PubMed Google Scholar 4. Hanahan, D. & Weinberg, R. A. Cell 144, 646–674 (2011). Article PubMed Google Scholar 5. López-Otin, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Cell 186, 243–278 (2023). Article PubMed Google Scholar 6. Visvader, J. E. Nature 469, 314–322 (2011). Article PubMed Google Scholar 7. Rodriguez, R., Schreiber, S. L. & Conrad, M. Mol. Cell 82, 728–740 (2022). Article PubMed Google Scholar 8. Mani, S. A. et al. Cell 133, 704–715 (2008). Article PubMed Google Scholar 9. Müller et al. Nature Chem. 12, 929–938 (2020). Article PubMed Google Scholar 10. Mai, T. T. et al. Nature Chem. 9, 1025–1033 (2017). Article PubMed Google Scholar Download references Reprints and permissions COMPETING INTERESTS The authors declare no competing interests. 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