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Brian Beliveau
@oligopain.bsky.social
1.8K followers1.5K following
47 posts
PI @ UW Genome Sciences | chromosome biology | 3D genome | chromatin | single
cell & spatial biology We develop technologies to study genomes and the things
that are made from them. Avid FISHer. beliveau.io



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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
2d
Upping my commute -> office experience, should have done this years ago
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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
19d
Happy holidays, from our mise to yours 🥘
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Reposted by
Brian Beliveau
‪wnoble.bsky.social‬ ‪@wnoble.bsky.social‬
·
23d
HiCFoundation is a Swiss army knife for Hi-C data. Any task that takes Hi-C as
input will benefit from our pre-trained model. You can do resolution
enhancement, reproducibility analysis, loop calling, prediction of epigenomic
profiles, or single-cell Hi-C analysis. tinyurl.com/v3nmp6np
A generalizable Hi-C foundation model for chromatin architecture, single-cell
and multi-omics analysis across species
Nuclear DNA is organized into a compact three-dimensional (3D) structure that
impacts critical cellular processes. High-throughput chromosome conformation
capture (Hi-C) is the most widely used method...
tinyurl.com
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Reposted by
Brian Beliveau
‪Pierre Peterlongo‬ ‪@pierrepeterlongo.bsky.social‬
·
2mo
🧬🔍There are 50 petabases of freely-available DNA sequencing data. We
introducing Logan Search which allows you to search for any DNA sequence in
minutes, bringing Earth’s largest genomic resource to your fingertips. 🏔️
logan-search.org 🏔️
#Genomics
#Bioinformatics
#OpenScience

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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
1mo
Allez cuisine to all y'alls cooking today 🦃 🥘

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Reposted by
Brian Beliveau
‪Abby Dernburg‬ ‪@adernburg.bsky.social‬
·
1mo
Ru-upping this thread from last year since the paper is now out!
@chenshuliu.bsky.social
identified a Piezo-dependent mechanism that enables C. elegans to sniff out “bad
eggs” and target them for destruction. www.science.org/doi/10.1126/...
Chemically induced proximity reveals a Piezo-dependent meiotic checkpoint at the
oocyte nuclear envelope
Sexual reproduction relies on robust quality control during meiosis. Assembly of
the synaptonemal complex between homologous chromosomes (synapsis) regulates
meiotic recombination and is crucial for a...
www.science.org
‪Abby Dernburg‬ ‪@adernburg.bsky.social‬
·
10/29/2023
I'm excited to introduce a new story from my lab in which we developed a new
tool for inducible proximity and used it to determine the molecular basis of the
"synapsis checkpoint," which @needhibhalla.bsky.social and I first described in
2005...
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Reposted by
Brian Beliveau
‪Dr. Caleb Stoltzfus‬ ‪@cstoltzfus.com‬
·
1mo
Whoa! Visualization of RNA gene expression in intact rodent brains using TRISCO
clearing and light-sheet
#microscopy
. www.science.org/doi/10.1126/...
Whole-brain spatial transcriptional analysis at cellular resolution
Recent advances in RNA analysis have deepened our understanding of cellular
states in biological tissues. However, a substantial gap remains in integrating
RNA expression data with spatial context acr...
www.science.org
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Reposted by
Brian Beliveau
‪Loïc A. Royer 💻🔬🧪‬ ‪@loicaroyer.bsky.social‬
·
1mo
My BlueSky 'inaugural' post is our classic rotating embryo video from our
recently published Zebrahub paper www.cell.com/cell/fulltex... “Zebrahub | Supp.
Video 3: Light-sheet time-lapse of Tg(h2afva:h2afva-mcherry ; mezzo:eGFP) embryo
starting at 50% epiboly.” on
#Vimeo
vimeo.com/803719225
Zebrahub | Supp. Video 3: Light-sheet time-lapse of Tg(h2afva:h2afva-mcherry ;
mezzo:eGFP) embryo starting at 50% epiboly.
This is "Zebrahub | Supp. Video 3: Light-sheet time-lapse of
Tg(h2afva:h2afva-mcherry ; mezzo:eGFP) embryo starting at 50% epiboly." by Loic
A. Royer on…
vimeo.com
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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
1mo
This has captured all of my feels. All of them. youtu.be/qSQKvnWnCtY?...
ZEDS DEAD - CHANNEL FLIPPING
YouTube video by Zeds Dead
youtu.be

Reposted by
Brian Beliveau
‪Dave Shechner‬ ‪@shechnerlab.bsky.social‬
·
1mo
It's my great pleasure to present the next big preprint from SheqLab! An
exciting application of our O-MAP platform that I hope will transform the study
of nuclear architecture. If you've ever wanted to dissect the subnuclear
"neighborhood" around an individual locus, read on! (1/30)

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Reposted by
Brian Beliveau
‪FPbase‬ ‪@fpbase.org‬
·
1mo
Finally got around to creating a basic Python wrapper for the FPbase API. Hope
it helps for those wanting to programmatically retrieve data from FPbase using
Python. pip install fpbase github.com/tlambert03/f...
GitHub - tlambert03/fpbasepy: Python wrapper for FPBase.org GraphQL API.
Python wrapper for FPBase.org GraphQL API. Contribute to tlambert03/fpbasepy
development by creating an account on GitHub.
github.com
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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
1mo
There are many great things about working at @UWGenome. This may be the
greatest. Been going for >2 years now! 🐱🗓️
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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
1mo
The most stressful channel on the workspace 🟨⬛🟩⬛⬛
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Reposted by
Brian Beliveau
‪Diana Libuda‬ ‪@dianalibuda.bsky.social‬
·
1mo
For
#MicroscopyMonday
, here is a pachytene stage chromosome from a
#zebrafish
spermatocyte, imaged with superresolution microscopy by postdoc
@cahooncori.bsky.social
who's starting her own lab at CSU Fort Collins in January 2025.
#meiosis4eva

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Reposted by
Brian Beliveau
‪Alison Feder‬ ‪@alisonfeder.bsky.social‬
·
1mo
Sharing again for new followers - check out this fully-funded postdoc to work
with any Fred Hutch comp bio faculty members! Pre-apps due Dec 20 to start next
year! www.fredhutch.org/en/research/...
Mahan Fellowship
Fred Hutch is dedicated to the development and advancement of biomedical
research to eliminate cancer and other potentially fatal diseases. As part of
that goal, we offer the Mahan postdoctoral fellow...
www.fredhutch.org
‪Alison Feder‬ ‪@alisonfeder.bsky.social‬
·
2mo
Are you a comp bio graduate student close to finishing your PhD? The Mahan
Fellowship is a fully-funded ~2 year postdoc to work with any Fred Hutch comp
bio faculty members! Pre-proposals are due Dec 20! Check out full details here:
apply.interfolio.com/157470 #ScienceJobs 🧪 #AcademicSky
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
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Reposted by
Brian Beliveau
‪Karolin Luger‬ ‪@nucleosomepolice.bsky.social‬
·
1mo
Our paper on the strange ATP-dependent chromatin remodeler Smarcad1 paper is out
and freely accessible. Differential regulation of its many activities by
phosphorylation. Congrats to Briana and
@nhoitsma.bsky.social
🧪https://www.sciencedirect.com/science/article/pii/S0021925824023950?via%3Dihub
Phosphorylation regulates the chromatin remodeler SMARCAD1 in nucleosome
binding, ATP hydrolysis, and histone exchange
Maintaining the dynamic structure of chromatin is critical for regulating the
cellular processes that require access to the DNA template, such as DNA …
www.sciencedirect.com
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Reposted by
Brian Beliveau
‪Barbara Mellone‬ ‪@centromellone.bsky.social‬
·
1mo
Our paper on a centromere-enriched retroelement is out!
link.springer.com/article/10.1... Congratulations to all the authors! Comments
and reposts welcome and appreciated 🧬🔬
Transcription of a centromere-enriched retroelement and local retention of its
RNA are significant features of the CENP-A chromatin landscape - Genome Biology
Background Centromeres depend on chromatin containing the conserved histone H3
variant CENP-A for function and inheritance, while the role of centromeric DNA
repeats remains unclear. Retroelements are...
link.springer.com
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Reposted by
Brian Beliveau
‪Teif lab‬ ‪@teiflab.bsky.social‬
·
1mo
Interesting new method to map nucleosomes in 3D, "Proximity Copy Paste (PCP)".
www.biorxiv.org/content/10.1... ▶️ mapped connectivity of nucleosomes in S.
cerevisiae ▶️ chromatin is predominantly organized into regularly spaced
nucleosome arrays ▶️ metaphase chromosomes packed by arrayed cohesin hubs
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Reposted by
Brian Beliveau
‪Ulrike Boehm‬ ‪@ulrikeboehm.bsky.social‬
·
1mo
🔬 Are you eager to dive into the world of light microscopy & learn from
top-notch microscopists about its essential techniques for life science
applications? If that sounds exciting, don’t miss out on this free, in-depth
iBiology series! 👉 www.ibiology.org/online-biolo...

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Reposted by
Brian Beliveau
‪Denis Wirtz‬ ‪@deniswirtz.bsky.social‬
·
1mo
Download our database of 313 different postdoctoral fellowships. For each entry,
we provide link to funder, description, amount, deadline, and eligibility
criteria (e.g. citizenship). Download our database here:
research.jhu.edu/rdt/funding-...

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Reposted by
Brian Beliveau
‪Mark Peifer (He. him)‬ ‪@peiferlabunc.bsky.social‬
·
1mo
In September the world lost one of the great biologists of our time: Joe Gall.
He bridged the transition from the histology era of cell biology to our
molecular present, contributing a remarkable set of insights in his 9 decades
1/n 🧪 rupress.org/jcb/article-...
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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
1mo
I can think of worse ways to spend a Friday night 🍕
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Reposted by
Brian Beliveau
‪Sheila Teves‬ ‪@sheilateves.bsky.social‬
·
1mo
Reintroducing myself to all the new folks here
‪Sheila Teves‬ ‪@sheilateves.bsky.social‬
·
10/10/2023
My first BlueSky post! Hello (blue) world. I'm an Assistant Professor of
Biochemistry in the University of Biritsh Columbia. My lab studies
transcriptional regulation. I tend to post mostly science, but expect to have a
peppering of mountain pics here and there. Excited to try this out!
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Reposted by
Brian Beliveau
‪Maitreyi Das‬ ‪@daslabpombe.com‬
·
1mo
For
#FluorescentFriday
enjoy this gorgeous video of fission yeast cells expressing Sla2-GFP and
Bqt4-mCherry. Video taken by Dr. Dhanya Kalathil from the Das lab.

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Reposted by
Brian Beliveau
‪Eric Vitriol‬ ‪@chillinwithpfn1.bsky.social‬
·
1mo
Hi everyone! Kicking off my first
#FluorescenceFriday
here with a 3D SIM image of actin, and of course had to go with my favorite blue
LUT (JDM Duo Intense Cyan) for Bluesky.

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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
1mo
The pSABER paper is now online! pSABER is a new method for amplifying in situ
hybridization signals This work was driven by Sahar Attar and co-led by Ram
Akliesh ([at] podocytes on the other app) with help from
@shechnerlab.bsky.social
@dschweppe.bsky.social
doi.org/10.1038/s415... 🧵 1/12
Efficient and highly amplified imaging of nucleic acid targets in cellular and
histopathological samples with pSABER - Nature Methods
pSABER combines the power of signal amplification by exchange reaction (SABER)
with the deposition of fluorescent or colorimetric substrates by horseradish
peroxidase to enable enhanced signals for in...
doi.org
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View full thread
‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
1mo
I was lucky enough to image another exchange-pSABER experiment carried out by
Sahar targeting three RNA species on our SoRa confocal. This might be my
favorite image ever taken. As a microscopist, it is hard to put into words just
how incredible i is to see this on the scope itself. 7/12

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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
1mo
Finally, a big benefit of pSABER being super bright is that you can readily
image it on low NA, air immersion objectives. SABER is essentially undetectable
on these systems. We are really excited about pSABER for applications like
optical screening 8/12
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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
1mo
Happy
#FluorescenceFriday
! Here are some HCT116 nuclei with some ... "friends" ... imaged on our SoRa
confocal Gave us quite the shock when we first saw it 😅

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Reposted by
Brian Beliveau
‪Merlin Lange‬ ‪@merlinlange.bsky.social‬
·
1mo
My first
#FluorescenceFriday
on the new sky! The emergence of the neural progenitor cells (magenta) in the
#zebrafish
embryos
#brain
🔬

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Reposted by
Brian Beliveau
‪Alissa Armstrong‬ ‪@armstrongflylab.bsky.social‬
·
1mo
A gorgeous
#Drosophila
ovariole for
#FluorescenceFriday
taken by Bluesky newcomer
@isaiahwill.bsky.social
- a graduate student in the lab. (path-Gal4 > UAS-2XEGFP)
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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
1mo
🎶 I'm not always there when you call... ...but I'm always on time 🎶
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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
1mo
Really brings joy to see the mass movement onto here! Looking forward to some
hope scrolling with y'all 🔬🐟 ❤️❤️
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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
1mo
Logging back on...

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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
11/2/2023
UW Genome Sciences has an opening for a computational biologist at the assistant
professor level. Deets 👇 Come and join an incredibly vibrant and collaborative
scientific community in beautiful Seattle! Please share / repost
apply.interfolio.com/135108

‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
10/5/2023
Glad to see the lab is making the most of freezer defrost day ☃️
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Reposted by
Brian Beliveau
‪Anders Sejr Hansen‬ ‪@andersshansen.bsky.social‬
·
9/23/2023
New preprint with Cerda-Smith, Hutchinson, Eyler, Wood et. al combining high-res
Region Capture Micro-C (RCMC) with CRISPRa screens to identify functional
enhancers of tumor supressor, PTEN, revealing separation between structural and
functional elements: www.biorxiv.org/content/10.1...

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Reposted by
Brian Beliveau
‪Karolin Luger‬ ‪@nucleosomepolice.bsky.social‬
·
9/23/2023
So, here I am. The nucleosome police now flies under their official tag. Please
follow me if you are interested in #chromatin, #nucleosome, #cryoEM,
#scienceeducation, #hiking, #quilting, and #nature. Help me figure out this
platform!
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Reposted by
Brian Beliveau
‪Maitreya Dunham‬ ‪@maitreya.bsky.social‬
·
9/23/2023
It's a two preprint day! Part of the continuing series with Bonny Brewer and
Raghu about our model for a special class of DNA amplifications. A unifying
model that explains the origins of human inverted copy number variants
www.biorxiv.org/content/10.1...
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‪Brian Beliveau‬ ‪@oligopain.bsky.social‬
·
9/23/2023
Is this where people are now? 👀
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PROFILE

Brian Beliveau

oligopain.bsky.social

did:plc:cpucktoyzfayyc3b7zxopceo

PI @ UW Genome Sciences | chromosome biology | 3D genome | chromatin | single
cell & spatial biology We develop technologies to study genomes and the things
that are made from them. Avid FISHer. beliveau.io