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Register Now - Automating FLImP: Macromolecular Structure Fingerprints for
Improved Cancer Therapy

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MICROSCOPY MASTERS

 


AUTOMATING FLIMP: MACROMOLECULAR STRUCTURE FINGERPRINTS FOR IMPROVED CANCER
THERAPY
WITH DR DANIEL ROLFE, STFC


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JOIN US ON SEPTEMBER 5, 2023


07:30 AM PDT | 10:30 AM EDT | 3:30 PM BST




ABOUT 

Understanding patient-specific macromolecular structure can lead to improved
drug therapies for diseases such as non-small cell lung cancer. This can often
be complicated as existing methods can lack the necessary resolution to
determine spatial organization of molecules. 

 

In the upcoming Microscopy Masters Webinar, Dr Dan Rolfe, Senior Link Scientist
at the Octopus Imaging Facility from STFC (Science and Technology Facilities
Council, UKRI), will discuss the work that they have been doing using TIRF
single-molecule localization microscopy and FLImP (Fluorophore Localization
Imaging with Photobleaching) to position fluorophores with 10 nm resolution. The
team have designed a workflow using ONI’s Nanoimager and automated data analysis
to map EGFR mutations in cancer that result in new oligomer assembly mechanisms
linked to tumor growth.

 

The session will also include a live Q&A where participants can submit any
queries to Dr Rolfe. Join us! 


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