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REVOLUTIONIZING NEUROLOGY THROUGH AI POWERED PRECISION MEDICINE

We believe every person with a neurological condition deserves to live their
best life starting today.  We leverage the world’s largest body of clinical
evidence in neurology, to create and deliver precision medicine by accelerating
the research, approval, and adoption of treatments.





UPGRADING THE STANDARD OF CARE AND IMPROVING OUTCOMES FOR PEOPLE WITH
NEUROLOGICAL MOVEMENT DISORDERS.

The PKG® system provides a continuous, objective assessment of movement disorder
symptoms, such as tremor, dyskinesia and bradykinesia during activities of daily
living and in the patient’s home environment.  Our industry leading, clinically
validated FDA Class II cleared algorithms power precision medicine for patients,
clinicians and our life science partners.


EVIDENCE

Access to 70 + Clinical papers


100%


IMPROVEMENT IN MDS-UPDRS SCORE USING PKG VS. STANDARD OF CARE


75%


OF THE TIME PKG INFLUENCES A
CHANGE IN MEDICATIONS


59%


IMPROVEMENT IN PATIENT DIALOGUE AND ENGAGEMENT REPORTED BY CLINICIANS


89%


OF PATIENTS SAID PKG PROVIDED DATA TO PHYSICIAN THEY COULD NOT PROVIDE


93%


OF PD PATIENTS SAID PKG
WAS EASY TO USE


12+


STUDIES VALIDATING RELIABILITY & RESPONSIVENESS

Dr. Peter Lin, a Movement Disorder Specialist from Valley Parkinson Clinic in
Los Gatos, California, "The PKG system has been very useful in my clinic by
giving me a window into the level of control of patient's motor symptoms on an
individualized and remote basis. This has helped me to adjust medication doses
and DBS programming as well as to engage the patient with a deeper discussion
and understanding of their symptoms."
Dr. Peter Lin

"Not only is it better far these people living with Parkinson's, but it is also
more efficient for the NHS - freeing up space and time in hospitals for our hard
working staff. "The cutting edge device is the latest in a long line of
world-leading innovations that the NHS is bringing to the frontline as part of
our NHS Long Term Plan commitment to use the most advanced technology possible
for our patients."
Amanda PritchardNHS chief executive

"Making healthcare more accessible and personalised is at the centre of our
plans for reform.
For people living with degenerative diseases like Parkinson's, it's important to
be able to communicate any changes in symptoms to your doctor quickly and
easily. This is a fantastic example of how technology is driving cutting -edge
innovation in healthcare, allowing remote monitoring of patients that can
dramatically improve their quality of lite and independence as well as freeing
up valuable clinician time."
Sajid JavidHealth and Social Care Secretary

Dr. Peter Lin, a Movement Disorder Specialist from Valley Parkinson Clinic in
Los Gatos, California, "The PKG system has been very useful in my clinic by
giving me a window into the level of control of patient's motor symptoms on an
individualized and remote basis. This has helped me to adjust medication doses
and DBS programming as well as to engage the patient with a deeper discussion
and understanding of their symptoms."
Dr. Peter Lin

"Not only is it better far these people living with Parkinson's, but it is also
more efficient for the NHS - freeing up space and time in hospitals for our hard
working staff. "The cutting edge device is the latest in a long line of
world-leading innovations that the NHS is bringing to the frontline as part of
our NHS Long Term Plan commitment to use the most advanced technology possible
for our patients."
Amanda PritchardNHS chief executive


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PROCESS

After receiving the PKG Watch, patient data is collected continuously during
activities of daily living and sleeping in the home environment and can be
programmed to remind the patient to take their prescription medications and then
records their compliance.

The PKG Watch, with its 10 day battery life, is worn continuously throughout the
day and night recording activity and inactivity in millisecond clips.



The PKG® system consists of a wearable recording device, patented algorithms and
an HCP portal which provides summaries and advanced analytics to help better
understand patients progression and responsiveness to treatments.  Patient and
caregiver apps are also available.



Wearable

Patient & caregiver
apps

Advanced algorithms for neurological disorders

HCP portal with advanced analytics

9 News Coverage
Watch VIdeo
Fred's Story
Watch VIdeo
Optimizing Treatments by One of Our founders
Watch VIdeo
Dr. Blackie Part 1 - Value of Objective Measurement
Part 1 of interview with Dr. Jeff Blackie covering use cases of the PKG and the
value of objective measurement
Watch Video
Dr. Blackie Part 2 - PKG Use Cases
Part 2 of interview with Dr. Jeff Blackie covering dose responsiveness, helping
with OFF periods, delayed ONs and immobility
Watch Video
Dr. Blackie Part 3 - Adjusting Treatment using PKG
Part 3 of interview with Dr. Jeff Blackie covering using PKG to adjust the
treatment of a fluctuator
Watch Video
Dr. Blackie Part 4 - Patient Case Study
Part 4 of interview with Dr. Jeff Blackie covering case study of a patient with
severe dyskinesia.
Watch Video
Dr. Blackie Part 5 - Overcoming Patient Reluctance using PKG
Part 5 of interview with Dr. Jeff Blackie covering how to use PKG to inform
patient interactions, including longitudinally/continuous.
Watch Video
Dr. Blackie Part 6 - Continuous use and Recommendations
Part 6 of interview with Dr. Jeff Blackie covering how the PKG informs treatment
using continuous monitoring and advice for others
Watch Video
Paz's Story
Watch Video
9 News Coverage
Watch VIdeo
Fred's Story
Watch VIdeo
Optimizing Treatments by One of Our founders
Watch VIdeo
Dr. Blackie Part 1 - Value of Objective Measurement
Part 1 of interview with Dr. Jeff Blackie covering use cases of the PKG and the
value of objective measurement
Watch Video
Dr. Blackie Part 2 - PKG Use Cases
Part 2 of interview with Dr. Jeff Blackie covering dose responsiveness, helping
with OFF periods, delayed ONs and immobility
Watch Video
Dr. Blackie Part 3 - Adjusting Treatment using PKG
Part 3 of interview with Dr. Jeff Blackie covering using PKG to adjust the
treatment of a fluctuator
Watch Video
Dr. Blackie Part 4 - Patient Case Study
Part 4 of interview with Dr. Jeff Blackie covering case study of a patient with
severe dyskinesia.
Watch Video
Dr. Blackie Part 5 - Overcoming Patient Reluctance using PKG
Part 5 of interview with Dr. Jeff Blackie covering how to use PKG to inform
patient interactions, including longitudinally/continuous.
Watch Video
Dr. Blackie Part 6 - Continuous use and Recommendations
Part 6 of interview with Dr. Jeff Blackie covering how the PKG informs treatment
using continuous monitoring and advice for others
Watch Video
Paz's Story
Watch Video
9 News Coverage
Watch VIdeo
Fred's Story
Watch VIdeo
Optimizing Treatments by One of Our founders
Watch VIdeo
Dr. Blackie Part 1 - Value of Objective Measurement
Part 1 of interview with Dr. Jeff Blackie covering use cases of the PKG and the
value of objective measurement
Watch Video
Dr. Blackie Part 2 - PKG Use Cases
Part 2 of interview with Dr. Jeff Blackie covering dose responsiveness, helping
with OFF periods, delayed ONs and immobility
Watch Video
Dr. Blackie Part 3 - Adjusting Treatment using PKG
Part 3 of interview with Dr. Jeff Blackie covering using PKG to adjust the
treatment of a fluctuator
Watch Video
Dr. Blackie Part 4 - Patient Case Study
Part 4 of interview with Dr. Jeff Blackie covering case study of a patient with
severe dyskinesia.
Watch Video
Dr. Blackie Part 5 - Overcoming Patient Reluctance using PKG
Part 5 of interview with Dr. Jeff Blackie covering how to use PKG to inform
patient interactions, including longitudinally/continuous.
Watch Video
Dr. Blackie Part 6 - Continuous use and Recommendations
Part 6 of interview with Dr. Jeff Blackie covering how the PKG informs treatment
using continuous monitoring and advice for others
Watch Video
Paz's Story
Watch Video

Previous slide
Next slide



PKG ALGORITHMS

The PKG® system contains the most comprehensive clinically validated algorithms
available in the neurological movement disorder market.  PKG algorithms not only
capture and process objective measurement of persons with movement disorders;
PKG also provides prospective insights and guidance on treatment decisions and
adjustments.


BRADYKINESIA


DYSKINESIA


TREMOR


DAYTIME IMMOBILITY


FLUCTUATIONS


NIGHTTIME
SLEEP


DEVICE ASSISTED THERAPY (CTS)


GAIT &
WALKING


WEARING
OFF


SYMPTOM & SIDE EFFECT MGMT (IN R&D)


RX
TITRATION (IN R&D)


RX
COMPLIANCE


OFF WRIST DETECTION





OFFERINGS

Clinical Care


CLINICAL CARE

Supporting both in-clinic care and remote patient monitoring, PKG Health offers
an FDA cleared, CE marked and TGA approved system to measure and inform
treatment decisions for patients with neurological movement disorders combining:


WEARABLES

PKG Health collects patient data and provides alerts through both its own
proprietary wearable (with a 7 day battery life) and a BYOD option, depending on
requirements.


PATIENT AND CAREGIVER APPS

Available on iOS and Android offering customized, white labelled patient
education, side effect management, patient reported outcomes, titration guidance
and more.


ALGORITHMS

Proven and patented using Al/ML. These measurement and digital therapeutics
algorithms inform treatment decisions and provide patients and HCPs insight into
their condition, medications, etc..


HCP PORTAL

Provides one location for managing all patients. It contains longitudinal
analytics on the patient condition evolution, enables staff to setup medication
reminders and provides summary scores to guide care.



Clinical Trial Services (CTS)


CLINICAL TRIAL SERVICES (CTS)

For life sciences sponsors and their CROs, clinical trials are all about
capturing patient responses to novel treatments. PKG Health stands alone as the
industry leader in capturing objective patient motor symptoms and key patient
reported outcomes (PROs) using wearables and our white labelled apps. With over
4,300 motor and non-motor data points collected weekly on each patient,
delivered intelligently via clinically validated and patented algorithms,
clinical trials can be accelerated with objective endpoints to better quantify
results.  Our technology and services have been deployed in over 70 clinical
studies globally



Digital Therapeutics (DTx)


DIGITAL THERAPEUTICS (DTX)

For life sciences companies, data-driven brand decisions are of utmost
criticality. Yet for many patients, this is overwhelmingly not the case. The
most critical success factor is ensuring both you and your HCP customer
thoroughly understand the facts on your shared patient; their behavior, their
challenges, their response to therapy. PKG Health offers life science companies
white labelled digital companions with embedded DTx to help brands maximize
their market opportunity. Objective real-time patient intelligence via patented,
clinically validated algorithms, patient education and engagement and powerful
AI/ML analytics optimizes the patient journey.





HISTORY


2007


GLOBAL KINETICS CORPORATION ESTABLISHED


2014 - 2016


REGULATORY CLEARANCES & INITIAL PATENTS


2016


PKG ALGORITHMS FOR ROUTINE CLINICAL CARE EXPAND GLOBALLY


2017- 2018


CLINICAL RESEARCH ALGORITHMS EXPANDED


2019


CONTINUOUS USE USE CASE LAUNCHED


2020 - 2021


PIVOTAL DATA PUBLISHED


2022


R&D FOR NEW ALGORITHMS
US MARKET INITIATION WITH VA


2023


GEN 3.0 WEARABLE
PKG4 REPORTING
MIDDLE EAST EXPANSION
R&D ON DIGITAL BIOMARKERS




LEADERSHIP


ZACH
HENDERSON

Chief Executive
Officer





THOMAS
ULMER

Chief Financial & Operating Officer





YURI
MARICICH

Chief Medical &
Scientific Officer





NEIL
STEVENS

Vice President
Europe/Middle East





MUHAMMAD
UMER

Chief Technology
Officer





DAN
BENNETT

Vice President
Partnerships



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Intended Use
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Copyright © 2023, Global Kinetics Pty Ltd. All Rights Reserved. PKG® and
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