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LEARN ABOUT TREATMENT WITH ALUNBRIG® (BRIGATINIB) FOR ALK+ METASTATIC NON-SMALL
CELL LUNG CANCER (MNSCLC)

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ERIC & MEGHAN'S STORY

Learn about how Eric and Meghan have navigated Eric’s ALK+ mNSCLC diagnosis,
their experience with ALUNBRIG, and how together they are living with lung
cancer.

Eric is a real ALUNBRIG patient


ViewHide Transcript

[Meghan]
Eric and I have been married for about 10 years, we have a pretty vibrant life. 
A lung cancer diagnosis made no sense to us. 
Often people say it's like having the rug pulled out from underneath you, when
you get a diagnosis like that. I correct them. And I say it's like the whole
floor, coming out from underneath you.
When we got that phone call or news from the physician of his cancer diagnosis,
I knew it would be a major inflection point in our life.

[Eric]
Prior to diagnosis, my health started to change in such a way that I was having
difficulty breathing. And I was coughing quite a bit.
The symptoms that I had, definitely felt like someone standing on my chest. I
was also having difficulty sleeping on my back, which led me to a lot more
sleepless nights.
It came up in a conversation with my wife and after she said, “Hey, I'm
concerned that your coughing is becoming uncontrollable. I think it's time for
you to visit your primary care physician.”
It was a very short period of time, I was able to go from an x-ray to a CT in
the same day. And then within two days, I was doing a biopsy.
The first time that I heard the word cancer, from my physician. I will never
forget those words.
At age 41. I was diagnosed with stage four ALK positive non-small cell lung
cancer. Receiving a diagnosis of this sort, made no sense to me.

[Meghan]
We've obviously subsequently learned that anyone with lungs can get lung cancer.

[Eric]
It took me a while to understand the impact of having brain metastases. And at
that point, I was honestly so defeated and downtrodden.
As my treatment options were explained to me, I had the choice of a few
different TKIs. I consulted with my family, my oncologists and other primary
care specialists to pick the best option for me based on the side effects and
the dosing. And for me, that choice was ALUNBRIG.
ALUNBRIG is a prescription medicine used to treat adults with non-small cell
lung cancer, NSCLC, that has a certain type of abnormal anaplastic lymphoma
kinase, ALK, gene and that has spread to other parts of your body. It is not
known if ALUNBRIG is safe and effective in children.
The most important factor when selecting ALUNBRIG was how it would impact my
life. And I looked at the side effects and the dosage. And those two combined,
made it feel that it would be the least impactful to my everyday life.
I've experienced bradycardia nausea and stomach pain while taking ALUNBRIG. But
these are not all of the possible side effects. And everyone is different.
Speak to your healthcare provider about all the potential side effects with
ALUNBRIG.

[Meghan]
The treatment was very easy to incorporate into our lives. Being able to take
one pill a day was of a significant benefit to him as well.

[Eric]
I started ALUNBRIG on the seven-day starter dosage of 90 milligrams, after which
I increased to 180 milligrams, which I currently take.

[Meghan]
From my perspective, Eric has responded really well to ALUNBRIG.
Fortunately, it had a rapid reduction in his tumor volume. He was able to
tolerate the medicine.

[Eric]
After reading my scan reports, one of the terms frequently used is
“unremarkable”.  That effectively means that while my tumors are still present,
they're not growing or spreading. So, I will happily claim to be an
“unremarkable cancer patient”.

[Meghan]
When Eric was first diagnosed with lung cancer, he was given a prognosis of nine
to 12 months. That timing then aligned with our 10-year wedding anniversary. So,
our goal became to make it to the anniversary.
And as we did, we elected to have a vow renewal ceremony with a number of family
and friends.
We're able to take less of the focus on his treatment and the worry and put it
more so into creating memories together.

[Eric]
The best piece of advice that I've received from my care is that you don't have
to hit a homerun your first at bat. You have to get on base. You have to stay
healthy enough to take advantage of technology and its advances.
And that's what gives me hope.


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IMPORTANT SAFETY INFORMATION, INDICATION, AND USAGE

Expand+


ALUNBRIG CAN CAUSE SERIOUS SIDE EFFECTS, INCLUDING:

 * Lung problems. ALUNBRIG may cause severe or life-threatening swelling
   (inflammation) of the lungs any time during treatment and can lead to death.
   These lung problems happen especially within the first week of treatment with
   ALUNBRIG. Symptoms may be similar to those symptoms from lung cancer. Tell
   your healthcare provider right away if you have any new or worsening
   symptoms. including: 
   * trouble breathing or shortness of breath
   * chest pain
   * cough with or without mucus
   * fever
      
 * High blood pressure (hypertension). ALUNBRIG may cause high blood pressure.
   Your healthcare provider will check your blood pressure before starting and
   during treatment with ALUNBRIG. Tell your healthcare provider right away if
   you get headaches, dizziness, blurred vision, chest pain or shortness of
   breath.
    
 * Slow heart rate (bradycardia). ALUNBRIG may cause very slow heartbeats that
   can be severe. Your healthcare provider will check your heart rate during
   treatment with ALUNBRIG. Tell your healthcare provider right away if you feel
   dizzy, lightheaded, or faint during treatment with ALUNBRIG. Tell your
   healthcare provider if you take any heart or blood pressure medicines.
    
 * Vision problems. ALUNBRIG may cause vision problems. Your healthcare provider
   may stop ALUNBRIG and refer you to an eye specialist if you develop severe
   vision problems during treatment with ALUNBRIG. Tell your healthcare provider
   right away if you have any loss of vision or any change in vision, including:
   * double vision
   * seeing flashes of light
   * blurry vision
   * light hurting your eyes
   * new or increased floaters
      
 * Muscle pain, tenderness, and weakness (myalgia). ALUNBRIG may increase the
   level of an enzyme in your blood called creatine phosphokinase (CPK), which
   may be a sign of muscle damage. Your healthcare provider will do blood tests
   to check your blood levels of CPK during treatment with ALUNBRIG. Tell your
   healthcare provider right away if you get new or worsening signs and symptoms
   of muscle problems, including unexplained muscle pain or muscle pain that
   does not go away, tenderness, or weakness.
    
 * Inflammation of the pancreas (pancreatitis). ALUNBRIG may increase enzymes in
   your blood called amylase and lipase, which may be a sign of pancreatitis.
   Your healthcare provider will do blood tests to check your pancreatic enzyme
   blood levels during treatment with ALUNBRIG. Tell your healthcare provider
   right away if you get new or worsening signs and symptoms of pancreatitis,
   including upper abdominal pain that may spread to the back and get worse with
   eating, weight loss, or nausea.
    
 * Liver problems (hepatotoxicity). ALUNBRIG may increase the levels of
   bilirubin in your blood and enzymes called aspartate aminotransferase (AST)
   and alanine aminotransferase (ALT) in your blood, which may be a sign of
   liver problems. Your healthcare provider will do blood tests to check your
   liver during treatment with ALUNBRIG. Tell your healthcare provider right
   away if you get new or worsening signs or symptoms, including:
   * yellowing of your skin or the white part of your eyes
   * dark or brown (tea color) urine
   * nausea or vomiting
   * pain on the right side of your stomach area
   * bleed or bruise more easily than normal
   * itchy skin
   * decreased appetite
   * feeling tired
      
 * High blood sugar (hyperglycemia). ALUNBRIG may increase your blood sugar
   levels. Your healthcare provider will do blood tests to check your blood
   sugar levels before starting and during treatment with ALUNBRIG. Your
   healthcare provider may need to start or change your blood sugar medicine to
   control your blood sugar levels. Tell your healthcare provider right away if
   you get new or worsening signs and symptoms of hyperglycemia, including:
   * feeling very thirsty
   * needing to urinate more than usual
   * feeling very hungry
   * feeling sick to your stomach
   * feeling weak or tired
   * feeling confused

The most common side effects of ALUNBRIG include diarrhea, fatigue, nausea,
rash, cough, muscle pain, headache, high blood pressure, vomiting and difficulty
breathing.

ALUNBRIG may cause fertility problems in males. This may affect your ability to
father a child. Talk to your healthcare provider if you have concerns about
fertility.

These are not all the possible side effects of ALUNBRIG. Call your doctor for
medical advice about side effects. You may report side effects to the FDA at
1-800-FDA-1088.


WHAT SHOULD I AVOID WHILE TAKING ALUNBRIG?

 * Limit your time in the sun during treatment with ALUNBRIG and for at least 5
   days after your final dose. ALUNBRIG may make your skin sensitive to
   sunlight. You may burn more easily and get severe sunburns. When you are in
   the sun, wear a hat and protective clothing, and use a broad-spectrum
   sunscreen and lip balm with a Sun Protection Factor (SPF) of 30 or greater to
   protect against sunburn.
 * Avoid eating grapefruit or drinking grapefruit juice during treatment with
   ALUNBRIG. Grapefruit may increase the amount of ALUNBRIG in your blood.

Before you take ALUNBRIG, tell your healthcare provider about all of your
medical conditions, including if you have lung or breathing problems, high blood
pressure, a slow heartbeat, or any vision problems, have or have had
pancreatitis, have liver problems, have diabetes mellitus or glucose
intolerance, have kidney problems or are on dialysis, are pregnant or plan to
become pregnant, or are breastfeeding or plan to breastfeed.

 * ALUNBRIG can harm your unborn baby. Your healthcare provider will determine
   whether or not you are pregnant before you start treatment with ALUNBRIG.
   Tell your healthcare provider right away if you become pregnant during
   treatment with ALUNBRIG or think you may be pregnant.
   * Females who are able to become pregnant should use effective birth control
     during treatment with ALUNBRIG and for at least 4 months after the final
     dose of ALUNBRIG. Talk to your healthcare provider about birth control
     choices that are right for you during treatment with ALUNBRIG.
   * Males who have female partners who are able to become pregnant should use
     effective birth control during treatment with ALUNBRIG and for at least 3
     months after the final dose of ALUNBRIG.
 * It is not known if ALUNBRIG passes into your breast milk. Do not breastfeed
   during treatment with ALUNBRIG and for 1 week after the final dose of
   ALUNBRIG.

Tell your healthcare provider about all the medicines you take, including
prescription medicines, over-the-counter medicines, vitamins, or herbal
supplements.

Please read the Patient Information in the full Prescribing Information and
discuss with your healthcare provider.


WHAT IS ALUNBRIG?



ALUNBRIG is a prescription medicine used to treat adults with non-small cell
lung cancer (NSCLC):

 * that has a certain type of abnormal anaplastic lymphoma kinase (ALK) gene,
   and
 * that has spread to other parts of your body

It is not known if ALUNBRIG is safe and effective in children.




IMPORTANT SAFETY INFORMATION


ALUNBRIG CAN CAUSE SERIOUS SIDE EFFECTS, INCLUDING:

 * Lung problems. ALUNBRIG may cause severe or life-threatening swelling
   (inflammation) of the lungs any time during treatment and can lead to death.
   These lung problems happen especially within the first week of treatment with
   ALUNBRIG. Symptoms may be similar to those symptoms from lung cancer. Tell
   your healthcare provider right away if you have any new or worsening
   symptoms. including: 
   * trouble breathing or shortness of breath
   * chest pain
   * cough with or without mucus
   * fever
      
 * High blood pressure (hypertension). ALUNBRIG may cause high blood pressure.
   Your healthcare provider will check your blood pressure before starting and
   during treatment with ALUNBRIG. Tell your healthcare provider right away if
   you get headaches, dizziness, blurred vision, chest pain or shortness of
   breath.
    
 * Slow heart rate (bradycardia). ALUNBRIG may cause very slow heartbeats that
   can be severe. Your healthcare provider will check your heart rate during
   treatment with ALUNBRIG. Tell your healthcare provider right away if you feel
   dizzy, lightheaded, or faint during treatment with ALUNBRIG. Tell your
   healthcare provider if you take any heart or blood pressure medicines.
    
 * Vision problems. ALUNBRIG may cause vision problems. Your healthcare provider
   may stop ALUNBRIG and refer you to an eye specialist if you develop severe
   vision problems during treatment with ALUNBRIG. Tell your healthcare provider
   right away if you have any loss of vision or any change in vision, including:
   * double vision
   * seeing flashes of light
   * blurry vision
   * light hurting your eyes
   * new or increased floaters
      
 * Muscle pain, tenderness, and weakness (myalgia). ALUNBRIG may increase the
   level of an enzyme in your blood called creatine phosphokinase (CPK), which
   may be a sign of muscle damage. Your healthcare provider will do blood tests
   to check your blood levels of CPK during treatment with ALUNBRIG. Tell your
   healthcare provider right away if you get new or worsening signs and symptoms
   of muscle problems, including unexplained muscle pain or muscle pain that
   does not go away, tenderness, or weakness.
    
 * Inflammation of the pancreas (pancreatitis). ALUNBRIG may increase enzymes in
   your blood called amylase and lipase, which may be a sign of pancreatitis.
   Your healthcare provider will do blood tests to check your pancreatic enzyme
   blood levels during treatment with ALUNBRIG. Tell your healthcare provider
   right away if you get new or worsening signs and symptoms of pancreatitis,
   including upper abdominal pain that may spread to the back and get worse with
   eating, weight loss, or nausea.
    
 * Liver problems (hepatotoxicity). ALUNBRIG may increase the levels of
   bilirubin in your blood and enzymes called aspartate aminotransferase (AST)
   and alanine aminotransferase (ALT) in your blood, which may be a sign of
   liver problems. Your healthcare provider will do blood tests to check your
   liver during treatment with ALUNBRIG. Tell your healthcare provider right
   away if you get new or worsening signs or symptoms, including:
   * yellowing of your skin or the white part of your eyes
   * dark or brown (tea color) urine
   * nausea or vomiting
   * pain on the right side of your stomach area
   * bleed or bruise more easily than normal
   * itchy skin
   * decreased appetite
   * feeling tired
      
 * High blood sugar (hyperglycemia). ALUNBRIG may increase your blood sugar
   levels. Your healthcare provider will do blood tests to check your blood
   sugar levels before starting and during treatment with ALUNBRIG. Your
   healthcare provider may need to start or change your blood sugar medicine to
   control your blood sugar levels. Tell your healthcare provider right away if
   you get new or worsening signs and symptoms of hyperglycemia, including:
   * feeling very thirsty
   * needing to urinate more than usual
   * feeling very hungry
   * feeling sick to your stomach
   * feeling weak or tired
   * feeling confused

The most common side effects of ALUNBRIG include diarrhea, fatigue, nausea,
rash, cough, muscle pain, headache, high blood pressure, vomiting and difficulty
breathing.

ALUNBRIG may cause fertility problems in males. This may affect your ability to
father a child. Talk to your healthcare provider if you have concerns about
fertility.

These are not all the possible side effects of ALUNBRIG. Call your doctor for
medical advice about side effects. You may report side effects to the FDA at
1-800-FDA-1088.


WHAT SHOULD I AVOID WHILE TAKING ALUNBRIG?

 * Limit your time in the sun during treatment with ALUNBRIG and for at least 5
   days after your final dose. ALUNBRIG may make your skin sensitive to
   sunlight. You may burn more easily and get severe sunburns. When you are in
   the sun, wear a hat and protective clothing, and use a broad-spectrum
   sunscreen and lip balm with a Sun Protection Factor (SPF) of 30 or greater to
   protect against sunburn.
 * Avoid eating grapefruit or drinking grapefruit juice during treatment with
   ALUNBRIG. Grapefruit may increase the amount of ALUNBRIG in your blood.

Before you take ALUNBRIG, tell your healthcare provider about all of your
medical conditions, including if you have lung or breathing problems, high blood
pressure, a slow heartbeat, or any vision problems, have or have had
pancreatitis, have liver problems, have diabetes mellitus or glucose
intolerance, have kidney problems or are on dialysis, are pregnant or plan to
become pregnant, or are breastfeeding or plan to breastfeed.

 * ALUNBRIG can harm your unborn baby. Your healthcare provider will determine
   whether or not you are pregnant before you start treatment with ALUNBRIG.
   Tell your healthcare provider right away if you become pregnant during
   treatment with ALUNBRIG or think you may be pregnant.
   * Females who are able to become pregnant should use effective birth control
     during treatment with ALUNBRIG and for at least 4 months after the final
     dose of ALUNBRIG. Talk to your healthcare provider about birth control
     choices that are right for you during treatment with ALUNBRIG.
   * Males who have female partners who are able to become pregnant should use
     effective birth control during treatment with ALUNBRIG and for at least 3
     months after the final dose of ALUNBRIG.
 * It is not known if ALUNBRIG passes into your breast milk. Do not breastfeed
   during treatment with ALUNBRIG and for 1 week after the final dose of
   ALUNBRIG.

Tell your healthcare provider about all the medicines you take, including
prescription medicines, over-the-counter medicines, vitamins, or herbal
supplements.

Please read the Patient Information in the full Prescribing Information and
discuss with your healthcare provider.


WHAT IS ALUNBRIG?

ALUNBRIG is a prescription medicine used to treat adults with non-small cell
lung cancer (NSCLC):

 * that has a certain type of abnormal anaplastic lymphoma kinase (ALK) gene,
   and
 * that has spread to other parts of your body

It is not known if ALUNBRIG is safe and effective in children.


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registered trademarks of Millennium Pharmaceuticals, Inc.
©2023 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 

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