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Skip to main content Google Tag Manager * Important Safety Information * Important Product Information * INVEGA SUSTENNA® * INVEGA TRINZA® * For Patients with Schizoaffective Disorder * For Healthcare Professionals * INVEGA SUSTENNA® * INVEGA TRINZA® Toggle navigation * Home * About schizophrenia * About schizophrenia * Treating schizophrenia in adults * Treatment Team * Caregivers * Janssen Portfolio of LAIs * Janssen Portfolio of LAIs * INVEGA SUSTENNA® * INVEGA TRINZA® * Support * Patient support * Cost support * Adults living with schizophrenia * Treatment Change Discussion Guide * FAQs * Glossary * INVEGA SUSTENNA® for Healthcare Professionals * INVEGA TRINZA® for Healthcare Professionals * For Patients with Schizoaffective Disorder × 1 2 3 4 5 WE WANT YOUR FEEDBACK! Would you take a brief survey so we can improve your experience on our website? I confirm that I am 18 years of age or older. I am 18 years or older * Close Please note: Responses here will not be monitored for immediate assistance. For help with our products or any other questions, please contact 1-800-JANSSEN (1-800-526-7736). SURVEY DISCLAIMER MESSAGE LINK Talk to your doctor if you have questions. Click here for Important Safety Information and Product Information for Invega Sustenna® or Invega Trinza®. Leave this field blank Click Here to Take Our Survey! Close THE JANSSEN PORTFOLIO OF LONG-ACTING INJECTIONS Featuring INVEGA SUSTENNA® and INVEGA TRINZA®. Same active ingredient, different long-acting treatment options for adult patients with schizophrenia. Jump to... * Top of page * What long-acting treatments can offer * Working on your recovery plan * Real advice from real patients WHAT LONG-ACTING TREATMENTS CAN OFFER You didn’t choose to live with schizophrenia, but you have a choice in how you manage it. It’s important to talk with your healthcare professional and learn about all the treatment options available to you, like a long-term approach to treatment with either INVEGA SUSTENNA® (paliperidone palmitate) and INVEGA TRINZA® (paliperidone palmitate) from the Janssen portfolio of long-acting injections (LAIs). Treatment with LAIs can help you feel confident that the medication you need is in your system for a month* or 3 months** with a single dose. LAIs can also help control schizophrenia symptoms in adults and help delay another episode. In a pivotal long-term study, 90% of adult patients taking INVEGA SUSTENNA® did not experience a significant return of schizophrenia symptoms vs 66% of those not treated. In a separate pivotal long-term study, 93% of adult patients taking INVEGA TRINZA® did not experience a significant return of schizophrenia symptoms vs 77% of those not treated. WHAT LONG-ACTING TREATMENTS CAN OFFER You didn’t choose to live with schizophrenia, but you have a choice in how you manage it. It’s important to talk with your healthcare professional and learn about all the treatment options available to you, like a long-term approach to treatment with either INVEGA SUSTENNA® (paliperidone palmitate) and INVEGA TRINZA® (paliperidone palmitate) from the Janssen portfolio of long-acting injections (LAIs). Treatment with LAIs can help you feel confident that the medication you need is in your system for a month* or 3 months** with a single dose. LAIs can also help control schizophrenia symptoms in adults and help delay another episode. In a pivotal long-term study, 90% of adult patients taking INVEGA SUSTENNA® did not experience a significant return of schizophrenia symptoms vs 66% of those not treated. In a separate pivotal long-term study, 93% of adult patients taking INVEGA TRINZA® did not experience a significant return of schizophrenia symptoms vs 77% of those not treated. The Janssen portfolio of LAIs has 2 treatment options with the same active ingredient, both designed to be gradually released to help control schizophrenia symptoms and delay time to another relapse in adults. INVEGA SUSTENNA® is given every month after 2 starting doses, and INVEGA TRINZA® is given once every 3 months to patients after they have been adequately treated with INVEGA SUSTENNA® for at least 4 months. *After receiving 2 starting doses when treating with INVEGA SUSTENNA®. **When treating with INVEGA TRINZA® after being adequately treated with INVEGA SUSTENNA® for approximately 4 months. The Janssen portfolio of LAIs has 2 treatment options with the same active ingredient, both designed to be gradually released to help control schizophrenia symptoms and delay time to another relapse in adults. INVEGA SUSTENNA® is given every month after 2 starting doses, and INVEGA TRINZA® is given once every 3 months to patients after they have been adequately treated with INVEGA SUSTENNA® for at least 4 months. *After receiving 2 starting doses when treating with INVEGA SUSTENNA®. **When treating with INVEGA TRINZA® after being adequately treated with INVEGA SUSTENNA® for approximately 4 months. WORKING ON YOUR RECOVERY PLAN When you’re not focused on controlling schizophrenia symptoms and another episode, you can focus more on moving forward with your personal treatment goals. The schizophrenia recovery journey isn’t an end point—it’s a process. That process is unique to you, so it will look different from what other people may be experiencing. Your treatment path on your way to your recovery plan can start with: Learning about schizophrenia Making an informed decision about which medication is right for you Working with your Treatment Team to help you make and achieve your goals Working with your loved one to help them make and achieve their goals Video Player is loading. Play Video Play Mute Current Time 0:00 / Duration 0:10 Loaded: 100.00% 0:00 Stream Type LIVE Seek to live, currently behind liveLIVE Remaining Time -0:10 1x Playback Rate Chapters * Chapters Descriptions * descriptions off, selected Captions * captions settings, opens captions settings dialog * captions off, selected Audio Track * default, selected Picture-in-PictureFullscreen This is a modal window. Beginning of dialog window. Escape will cancel and close the window. TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaque Font Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall Caps Reset restore all settings to the default valuesDone Close Modal Dialog End of dialog window. Close Modal Dialog This is a modal window. This modal can be closed by pressing the Escape key or activating the close button. * Elizabeth is a volunteer with the SHARE Network, a volunteer program dedicated to helping adults living with schizophrenia share their personal health stories. REAL ADVICE FROM REAL PATIENTS* Learn about LAIs POTENTIAL SIDE EFFECTS As with any medicine, INVEGA SUSTENNA® or INVEGA TRINZA® may cause side effects in some people, so the risks are important to consider as you and your healthcare professional make decisions about your treatment. The most common side effects for INVEGA SUSTENNA® include: injection site reactions, sleepiness or drowsiness, dizziness, feeling of inner restlessness or needing to be constantly moving, and abnormal muscle movements, including tremor (shaking), shuffling, uncontrolled involuntary movements, and abnormal movements of your eyes. The most common side effects of INVEGA TRINZA® include: injection site reactions, weight gain, headache, upper respiratory tract infections, feeling restlessness or difficulty sitting still, slow movements, tremors, stiffness and shuffling walk. Tell your Treatment Team if you have any side effect that bothers you or does not go away. INDICATIONS INDICATIONS INVEGA TRINZA® (3-month paliperidone palmitate) is a prescription medicine given by injection every 3 months by a healthcare professional and used to treat schizophrenia. INVEGA TRINZA® is used in people who have been treated with INVEGA SUSTENNA® (1-month paliperidone palmitate) for at least 4 months. INVEGA SUSTENNA® (In-VEY-guh Suss-TEN-uh) (paliperidone palmitate) is a prescription medicine given by injection by a healthcare professional. INVEGA SUSTENNA® is used to treat schizophrenia in adults. IMPORTANT SAFETY INFORMATION What is the most important information I should know about INVEGA TRINZA® and INVEGA SUSTENNA®? INVEGA TRINZA® and INVEGA SUSTENNA® can cause serious side effects, including an increased risk of death in elderly people who are confused, have memory loss, and have lost touch with reality (dementia-related psychosis). INVEGA TRINZA® and INVEGA SUSTENNA® are not for treating dementia-related psychosis. Do not receive INVEGA TRINZA® or INVEGA SUSTENNA® if you are allergic to paliperidone, paliperidone palmitate, risperidone, or any of the ingredients in INVEGA TRINZA® or INVEGA SUSTENNA®. See the end of the Patient Information leaflet in the full Prescribing Information for a complete list of INVEGA TRINZA® and INVEGA SUSTENNA® ingredients. Before you receive INVEGA TRINZA® or INVEGA SUSTENNA®, tell your healthcare professional about all your medical conditions, including if you: * have had Neuroleptic Malignant Syndrome (NMS) * have or have had heart problems, including a heart attack, heart failure, abnormal heart rhythm, or long QT syndrome * have or have had low levels of potassium or magnesium in your blood * have or have had uncontrolled movements of your tongue, face, mouth, or jaw (tardive dyskinesia) * have or have had kidney or liver problems * have diabetes or have a family history of diabetes * have had a low white blood cell count * have had problems with dizziness or fainting or are being treated for high blood pressure * have or have had seizures or epilepsy * have any other medical conditions * are pregnant or plan to become pregnant. It is not known if INVEGA TRINZA® or INVEGA SUSTENNA® will harm your unborn baby * If you become pregnant while taking INVEGA TRINZA® or INVEGA SUSTENNA®, talk to your healthcare professional about registering with the National Pregnancy Registry for Atypical Antipsychotics. You can register by calling 1-866-961-2388 or visit http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry. * Infants born to women who are treated with INVEGA TRINZA® or INVEGA SUSTENNA® may experience symptoms such as tremors, irritability, excessive sleepiness, eye twitching, muscle spasms, decreased appetite, difficulty breathing, or abnormal movement of arms and legs. Let your healthcare professional know if these symptoms occur. * are breastfeeding or plan to breastfeed. INVEGA TRINZA® or INVEGA SUSTENNA® can pass into your breast milk. Talk to your healthcare professional about the best way to feed your baby if you receive INVEGA TRINZA® or INVEGA SUSTENNA®. Tell your healthcare professional about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show to your healthcare professional or pharmacist when you get a new medicine. Patients (particularly the elderly) taking antipsychotics with certain health conditions or those on long-term therapy should be evaluated by their healthcare professional for the potential risk of falls. What should I avoid while receiving INVEGA TRINZA® or INVEGA SUSTENNA®? * INVEGA TRINZA® and INVEGA SUSTENNA® may affect your ability to make decisions, think clearly, or react quickly. Do not drive, operate heavy machinery, or do other dangerous activities until you know how INVEGA TRINZA® or INVEGA SUSTENNA® affects you. * Avoid getting overheated or dehydrated. INVEGA TRINZA® and INVEGA SUSTENNA® may cause serious side effects, including: * See “What is the most important information I should know about INVEGA TRINZA® and INVEGA SUSTENNA®?” * stroke in elderly people (cerebrovascular problems) that can lead to death * Neuroleptic Malignant Syndrome (NMS). NMS is a rare but very serious problem that can happen in people who receive INVEGA TRINZA® or INVEGA SUSTENNA®. NMS can cause death and must be treated in a hospital. Call your healthcare professional right away if you become severely ill and have any of these symptoms: high fever; severe muscle stiffness; confusion; loss of consciousness; changes in your breathing, heartbeat, and blood pressure. * problems with your heartbeat. These heart problems can cause death. Call your healthcare professional right away if you have any of these symptoms: passing out or feeling like you will pass out, dizziness, or feeling as if your heart is pounding or missing beats. * uncontrolled movements of your tongue, face, mouth, or jaw (tardive dyskinesia) * metabolic changes. Metabolic changes may include high blood sugar (hyperglycemia), diabetes mellitus and changes in the fat levels in your blood (dyslipidemia), and weight gain. * low blood pressure and fainting * changes in your blood cell counts * high level of prolactin in your blood (hyperprolactinemia). INVEGA TRINZA® or INVEGA SUSTENNA® may cause a rise in the blood levels of a hormone called prolactin (hyperprolactinemia) that may cause side effects including missed menstrual periods, leakage of milk from the breasts, development of breasts in men, or problems with erection. * problems thinking clearly and moving your body * seizures * difficulty swallowing that can cause food or liquid to get into your lungs * prolonged or painful erection lasting more than 4 hours. Call your healthcare professional or go to your nearest emergency room right away if you have an erection that lasts more than 4 hours. * problems with control of your body temperature, especially when you exercise a lot or spend time doing things that make you warm. It is important for you to drink water to avoid dehydration. The most common side effects of INVEGA TRINZA® include: injection site reactions, weight gain, headache, upper respiratory tract infections, feeling restlessness or difficulty sitting still, slow movements, tremors, stiffness and shuffling walk. The most common side effects of INVEGA SUSTENNA® include: injection site reactions; sleepiness or drowsiness; dizziness; feeling of inner restlessness or needing to be constantly moving; abnormal muscle movements, including tremor (shaking), shuffling, uncontrolled involuntary movements, and abnormal movements of your eyes. Tell your healthcare professional if you have any side effect that bothers you or does not go away. These are not all the possible side effects of INVEGA TRINZA® or INVEGA SUSTENNA®. For more information, ask your healthcare professional or pharmacist. Call your healthcare professional for medical advice about side effects. You may report side effects of prescription drugs to the FDA at 1‑800‑FDA‑1088. General information about the safe and effective use of INVEGA TRINZA® or INVEGA SUSTENNA® Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use INVEGA TRINZA® or INVEGA SUSTENNA® for a condition for which it was not prescribed. Do not give INVEGA TRINZA® or INVEGA SUSTENNA® to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare professional for information about INVEGA TRINZA® or INVEGA SUSTENNA® that is written for healthcare professionals. This Patient Information leaflet summarizes the most important information about INVEGA TRINZA® and INVEGA SUSTENNA®. If you would like more information, talk with your healthcare professional. You can ask your healthcare professional or pharmacist for more information that is written for healthcare professionals. For more information, go to www.invegatrinza.com or www.invegasustenna.com or call 1‑800‑526‑7736. Please click to read the full Prescribing Information, including Boxed WARNING, for INVEGA TRINZA® and INVEGA SUSTENNA® and discuss any questions you have with your healthcare professional. cp-64207v2 × The information contained in this section of the site is intended for US healthcare professionals only. Click the appropriate link below: I am a healthcare professional Close × The information contained in this section of the site is intended for US healthcare professionals only. Click the appropriate link below: I am a healthcare professional Close * Legal notice * Privacy policy * Contact us * Site map © Janssen Pharmaceuticals, Inc. 2021. This site is published by Janssen Pharmaceuticals, Inc., which is solely responsible for its contents. The material on this site is intended only as informational or as an educational aid and it is not intended to be taken as medical advice. The ultimate responsibility for patient care resides with a healthcare professional. This information is intended for the use of patients and caregivers in the United States and Puerto Rico only. Laws, regulatory requirements, and medical practices for pharmaceutical products vary from country to country. The Prescribing Information included here may not be appropriate for use outside the United States and Puerto Rico. Third party trademarks used herein are trademarks of their respective owners. Legal Notice | Privacy Policy | Contact UsSite Map Do not sell my personal information Last updated March 2021 © Janssen Pharmaceuticals, Inc. 2021 cp-166005v1 Last Updated March 2021 Thank you for visiting www.janssenschizophreniainjections.com. By clicking “continue” below, you will be taken to [extlink:external-url], a Web site that may contain links or references to other Web sites to which our Privacy Policy may not apply. We encourage you to read the Privacy Policy of every Web site you visit. Our Privacy Policy is located at privacy-policy. You are solely responsible for your interactions with such Web sites. Cancel Continue INDICATIONS INDICATIONS INVEGA TRINZA® (3-month paliperidone palmitate) is a prescription medicine given by injection every 3 months by a healthcare professional and used to treat schizophrenia. INVEGA TRINZA® is used in people who have been treated with INVEGA SUSTENNA® (1-month paliperidone palmitate) for at least 4 months. INVEGA SUSTENNA® (In-VEY-guh Suss-TEN-uh) (paliperidone palmitate) is a prescription medicine given by injection by a healthcare professional. INVEGA SUSTENNA® is used to treat schizophrenia in adults. IMPORTANT SAFETY INFORMATION What is the most important information I should know about INVEGA TRINZA® and INVEGA SUSTENNA®? INVEGA TRINZA® and INVEGA SUSTENNA® can cause serious side effects, including an increased risk of death in elderly people who are confused, have memory loss, and have lost touch with reality (dementia-related psychosis). INVEGA TRINZA® and INVEGA SUSTENNA® are not for treating dementia-related psychosis. Do not receive INVEGA TRINZA® or INVEGA SUSTENNA® if you are allergic to paliperidone, paliperidone palmitate, risperidone, or any of the ingredients in INVEGA TRINZA® or INVEGA SUSTENNA®. See the end of the Patient Information leaflet in the full Prescribing Information for a complete list of INVEGA TRINZA® and INVEGA SUSTENNA® ingredients. Before you receive INVEGA TRINZA® or INVEGA SUSTENNA®, tell your healthcare professional about all your medical conditions, including if you: * have had Neuroleptic Malignant Syndrome (NMS) * have or have had heart problems, including a heart attack, heart failure, abnormal heart rhythm, or long QT syndrome * have or have had low levels of potassium or magnesium in your blood * have or have had uncontrolled movements of your tongue, face, mouth, or jaw (tardive dyskinesia) * have or have had kidney or liver problems * have diabetes or have a family history of diabetes * have had a low white blood cell count * have had problems with dizziness or fainting or are being treated for high blood pressure * have or have had seizures or epilepsy * have any other medical conditions * are pregnant or plan to become pregnant. It is not known if INVEGA TRINZA® or INVEGA SUSTENNA® will harm your unborn baby * If you become pregnant while taking INVEGA TRINZA® or INVEGA SUSTENNA®, talk to your healthcare professional about registering with the National Pregnancy Registry for Atypical Antipsychotics. You can register by calling 1-866-961-2388 or visit http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry. * Infants born to women who are treated with INVEGA TRINZA® or INVEGA SUSTENNA® may experience symptoms such as tremors, irritability, excessive sleepiness, eye twitching, muscle spasms, decreased appetite, difficulty breathing, or abnormal movement of arms and legs. Let your healthcare professional know if these symptoms occur. * are breastfeeding or plan to breastfeed. INVEGA TRINZA® or INVEGA SUSTENNA® can pass into your breast milk. Talk to your healthcare professional about the best way to feed your baby if you receive INVEGA TRINZA® or INVEGA SUSTENNA®. Tell your healthcare professional about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show to your healthcare professional or pharmacist when you get a new medicine. Patients (particularly the elderly) taking antipsychotics with certain health conditions or those on long-term therapy should be evaluated by their healthcare professional for the potential risk of falls. What should I avoid while receiving INVEGA TRINZA® or INVEGA SUSTENNA®? * INVEGA TRINZA® and INVEGA SUSTENNA® may affect your ability to make decisions, think clearly, or react quickly. Do not drive, operate heavy machinery, or do other dangerous activities until you know how INVEGA TRINZA® or INVEGA SUSTENNA® affects you. * Avoid getting overheated or dehydrated. INVEGA TRINZA® and INVEGA SUSTENNA® may cause serious side effects, including: * See “What is the most important information I should know about INVEGA TRINZA® and INVEGA SUSTENNA®?” * stroke in elderly people (cerebrovascular problems) that can lead to death * Neuroleptic Malignant Syndrome (NMS). NMS is a rare but very serious problem that can happen in people who receive INVEGA TRINZA® or INVEGA SUSTENNA®. NMS can cause death and must be treated in a hospital. Call your healthcare professional right away if you become severely ill and have any of these symptoms: high fever; severe muscle stiffness; confusion; loss of consciousness; changes in your breathing, heartbeat, and blood pressure. * problems with your heartbeat. These heart problems can cause death. Call your healthcare professional right away if you have any of these symptoms: passing out or feeling like you will pass out, dizziness, or feeling as if your heart is pounding or missing beats. * uncontrolled movements of your tongue, face, mouth, or jaw (tardive dyskinesia) * metabolic changes. Metabolic changes may include high blood sugar (hyperglycemia), diabetes mellitus and changes in the fat levels in your blood (dyslipidemia), and weight gain. * low blood pressure and fainting * changes in your blood cell counts * high level of prolactin in your blood (hyperprolactinemia). INVEGA TRINZA® or INVEGA SUSTENNA® may cause a rise in the blood levels of a hormone called prolactin (hyperprolactinemia) that may cause side effects including missed menstrual periods, leakage of milk from the breasts, development of breasts in men, or problems with erection. * problems thinking clearly and moving your body * seizures * difficulty swallowing that can cause food or liquid to get into your lungs * prolonged or painful erection lasting more than 4 hours. Call your healthcare professional or go to your nearest emergency room right away if you have an erection that lasts more than 4 hours. * problems with control of your body temperature, especially when you exercise a lot or spend time doing things that make you warm. It is important for you to drink water to avoid dehydration. The most common side effects of INVEGA TRINZA® include: injection site reactions, weight gain, headache, upper respiratory tract infections, feeling restlessness or difficulty sitting still, slow movements, tremors, stiffness and shuffling walk. The most common side effects of INVEGA SUSTENNA® include: injection site reactions; sleepiness or drowsiness; dizziness; feeling of inner restlessness or needing to be constantly moving; abnormal muscle movements, including tremor (shaking), shuffling, uncontrolled involuntary movements, and abnormal movements of your eyes. Tell your healthcare professional if you have any side effect that bothers you or does not go away. These are not all the possible side effects of INVEGA TRINZA® or INVEGA SUSTENNA®. For more information, ask your healthcare professional or pharmacist. Call your healthcare professional for medical advice about side effects. You may report side effects of prescription drugs to the FDA at 1‑800‑FDA‑1088. General information about the safe and effective use of INVEGA TRINZA® or INVEGA SUSTENNA® Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use INVEGA TRINZA® or INVEGA SUSTENNA® for a condition for which it was not prescribed. Do not give INVEGA TRINZA® or INVEGA SUSTENNA® to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare professional for information about INVEGA TRINZA® or INVEGA SUSTENNA® that is written for healthcare professionals. This Patient Information leaflet summarizes the most important information about INVEGA TRINZA® and INVEGA SUSTENNA®. If you would like more information, talk with your healthcare professional. You can ask your healthcare professional or pharmacist for more information that is written for healthcare professionals. For more information, go to www.invegatrinza.com or www.invegasustenna.com or call 1‑800‑526‑7736. Please click to read the full Prescribing Information, including Boxed WARNING, for INVEGA TRINZA® and INVEGA SUSTENNA® and discuss any questions you have with your healthcare professional. cp-64207v2