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 * Important Safety Information
 * Important Product Information
   
   * INVEGA SUSTENNA®
   * INVEGA TRINZA®
 * For Patients with Schizoaffective Disorder
 * For Healthcare Professionals
   
   * INVEGA SUSTENNA®
   * INVEGA TRINZA®


Toggle navigation
 * Home
 * About schizophrenia
   
   * About schizophrenia
   * Treating schizophrenia
      in adults
   * Treatment Team
   * Caregivers
 * Janssen Portfolio of LAIs
   
   * Janssen Portfolio of LAIs
   * INVEGA SUSTENNA®
   * INVEGA TRINZA®
 * Support
   
   * Patient support
   * Cost support
   * Adults living with schizophrenia
   * Treatment Change Discussion Guide
   * FAQs
   * Glossary

 * INVEGA SUSTENNA® for
   Healthcare Professionals
 * INVEGA TRINZA® for
   Healthcare Professionals
 * For Patients with
   Schizoaffective Disorder




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Sustenna® or Invega Trinza®.

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THE JANSSEN PORTFOLIO OF LONG-ACTING INJECTIONS


Featuring INVEGA SUSTENNA® and 
INVEGA TRINZA®. Same active ingredient, different
 long-acting treatment options for adult patients with schizophrenia.

Jump to...
 * Top of page
 * What long-acting treatments can offer
 * Working on your recovery plan
 * Real advice from real patients


WHAT LONG-ACTING TREATMENTS CAN OFFER


You didn’t choose to live with schizophrenia, but you have a choice in how you
manage it. It’s important to talk with your healthcare professional and learn
about all the treatment options available to you, like a long-term approach to
treatment with either INVEGA SUSTENNA® (paliperidone palmitate) and INVEGA
TRINZA® (paliperidone palmitate) from the Janssen portfolio of long-acting
injections (LAIs).

Treatment with LAIs can help you feel confident that the medication you need is
in your system for a month* or 3 months** with a single dose. LAIs can also help
control schizophrenia symptoms in adults and help delay another episode.

In a pivotal long-term study, 90% of adult patients taking INVEGA SUSTENNA® did
not experience a significant return of schizophrenia symptoms vs 66% of those
not treated. In a separate pivotal long-term study, 93% of adult patients taking
INVEGA TRINZA® did not experience a significant return of schizophrenia symptoms
vs 77% of those not treated.


WHAT LONG-ACTING TREATMENTS CAN OFFER


You didn’t choose to live with schizophrenia, but you have a choice in how you
manage it. It’s important to talk with your healthcare professional and learn
about all the treatment options available to you, like a long-term approach to
treatment with either INVEGA SUSTENNA® (paliperidone palmitate) and INVEGA
TRINZA® (paliperidone palmitate) from the Janssen portfolio of long-acting
injections (LAIs).

Treatment with LAIs can help you feel confident that the medication you need is
in your system for a month* or 3 months** with a single dose. LAIs can also help
control schizophrenia symptoms in adults and help delay another episode.

In a pivotal long-term study, 90% of adult patients taking INVEGA SUSTENNA® did
not experience a significant return of schizophrenia symptoms vs 66% of those
not treated. In a separate pivotal long-term study, 93% of adult patients taking
INVEGA TRINZA® did not experience a significant return of schizophrenia symptoms
vs 77% of those not treated.

The Janssen portfolio of LAIs has 2 treatment options with the same active
ingredient, both designed to be gradually released to help control schizophrenia
symptoms and delay time to another relapse in adults. INVEGA SUSTENNA® is given
every month after 2 starting doses, and INVEGA TRINZA® is given once every 3
months to patients after they have been adequately treated with INVEGA SUSTENNA®
for at least 4 months.

*After receiving 2 starting doses when treating with INVEGA SUSTENNA®.

**When treating with INVEGA TRINZA® after being adequately treated with INVEGA
SUSTENNA® for approximately 4 months.

The Janssen portfolio of LAIs has 2 treatment options with the same active
ingredient, both designed to be gradually released to help control schizophrenia
symptoms and delay time to another relapse in adults. INVEGA SUSTENNA® is given
every month after 2 starting doses, and INVEGA TRINZA® is given once every 3
months to patients after they have been adequately treated with INVEGA SUSTENNA®
for at least 4 months.

*After receiving 2 starting doses when treating with INVEGA SUSTENNA®.

**When treating with INVEGA TRINZA® after being adequately treated with INVEGA
SUSTENNA® for approximately 4 months.


WORKING ON YOUR RECOVERY PLAN


When you’re not focused on controlling schizophrenia symptoms and another
episode, you can focus more on moving forward with your personal treatment
goals. The schizophrenia recovery journey isn’t an end point—it’s a process.
That process is unique to you, so it will look different from what other people
may be experiencing. Your treatment path on your way to your recovery plan can
start with:

Learning about schizophrenia
Making an informed decision about which medication is right for you
Working with your Treatment Team to help you make and achieve your goals
Working with your loved one to help them make and achieve their goals
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* Elizabeth is a volunteer with the SHARE Network, a volunteer program dedicated
to helping adults living with schizophrenia share their personal health stories.


REAL ADVICE FROM 
REAL PATIENTS*


Learn about LAIs


POTENTIAL SIDE 
EFFECTS


As with any medicine, INVEGA SUSTENNA® or INVEGA TRINZA® may cause side effects
in some people, so the risks are important to consider as you and your
healthcare professional make decisions about your treatment.

The most common side effects for INVEGA SUSTENNA® include: injection site
reactions, sleepiness or drowsiness, dizziness, feeling of inner restlessness or
needing to be constantly moving, and abnormal muscle movements, including tremor
(shaking), shuffling, uncontrolled involuntary movements, and abnormal movements
of your eyes.

The most common side effects of INVEGA TRINZA® include: injection site
reactions, weight gain, headache, upper respiratory tract infections, feeling
restlessness or difficulty sitting still, slow movements, tremors, stiffness and
shuffling walk.

Tell your Treatment Team if you have any side effect that bothers you or does
not go away.


INDICATIONS

INDICATIONS

INVEGA TRINZA® (3-month paliperidone palmitate) is a prescription medicine given
by injection every 3 months by a healthcare professional and used to treat
schizophrenia. INVEGA TRINZA® is used in people who have been treated with
INVEGA SUSTENNA® (1-month paliperidone palmitate) for at least 4 months.

INVEGA SUSTENNA® (In-VEY-guh Suss-TEN-uh) (paliperidone palmitate) is a
prescription medicine given by injection by a healthcare professional. INVEGA
SUSTENNA® is used to treat schizophrenia in adults.




IMPORTANT SAFETY INFORMATION

What is the most important information I should know about INVEGA TRINZA® and
INVEGA SUSTENNA®?

INVEGA TRINZA® and INVEGA SUSTENNA® can cause serious side effects, including an
increased risk of death in elderly people who are confused, have memory loss,
and have lost touch with reality (dementia-related psychosis). INVEGA TRINZA®
and INVEGA SUSTENNA® are not for treating dementia-related psychosis.

Do not receive INVEGA TRINZA® or INVEGA SUSTENNA® if you are allergic to
paliperidone, paliperidone palmitate, risperidone, or any of the ingredients in
INVEGA TRINZA® or INVEGA SUSTENNA®. See the end of the Patient Information
leaflet in the full Prescribing Information for a complete list of INVEGA
TRINZA® and INVEGA SUSTENNA® ingredients.

Before you receive INVEGA TRINZA® or INVEGA SUSTENNA®, tell your healthcare
professional about all your medical conditions, including if you:

 * have had Neuroleptic Malignant Syndrome (NMS)
 * have or have had heart problems, including a heart attack, heart failure,
   abnormal heart rhythm, or long QT syndrome
 * have or have had low levels of potassium or magnesium in your blood
 * have or have had uncontrolled movements of your tongue, face, mouth, or jaw
   (tardive dyskinesia)
 * have or have had kidney or liver problems
 * have diabetes or have a family history of diabetes
 * have had a low white blood cell count
 * have had problems with dizziness or fainting or are being treated for high
   blood pressure
 * have or have had seizures or epilepsy
 * have any other medical conditions
 * are pregnant or plan to become pregnant. It is not known if INVEGA TRINZA® or
   INVEGA SUSTENNA® will harm your unborn baby
   * If you become pregnant while taking INVEGA TRINZA® or INVEGA SUSTENNA®,
     talk to your healthcare professional about registering with the National
     Pregnancy Registry for Atypical Antipsychotics. You can register by calling
     1-866-961-2388 or
     visit http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry.
   * Infants born to women who are treated with INVEGA TRINZA® or INVEGA
     SUSTENNA® may experience symptoms such as tremors, irritability, excessive
     sleepiness, eye twitching, muscle spasms, decreased appetite, difficulty
     breathing, or abnormal movement of arms and legs. Let your healthcare
     professional know if these symptoms occur.
 * are breastfeeding or plan to breastfeed. INVEGA TRINZA® or INVEGA SUSTENNA®
   can pass into your breast milk. Talk to your healthcare professional about
   the best way to feed your baby if you receive INVEGA TRINZA® or INVEGA
   SUSTENNA®.

Tell your healthcare professional about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.
Know the medicines you take. Keep a list of them to show to your healthcare
professional or pharmacist when you get a new medicine.

Patients (particularly the elderly) taking antipsychotics with certain health
conditions or those on long-term therapy should be evaluated by their healthcare
professional for the potential risk of falls.

What should I avoid while receiving INVEGA TRINZA® or INVEGA SUSTENNA®?

 * INVEGA TRINZA® and INVEGA SUSTENNA® may affect your ability to make
   decisions, think clearly, or react quickly. Do not drive, operate heavy
   machinery, or do other dangerous activities until you know how INVEGA
   TRINZA® or INVEGA SUSTENNA® affects you.
 * Avoid getting overheated or dehydrated.

INVEGA TRINZA® and INVEGA SUSTENNA® may cause serious side effects, including:

 * See “What is the most important information I should know about INVEGA
   TRINZA® and INVEGA SUSTENNA®?”
 * stroke in elderly people (cerebrovascular problems) that can lead to death
 * Neuroleptic Malignant Syndrome (NMS). NMS is a rare but very serious problem
   that can happen in people who receive INVEGA TRINZA® or INVEGA SUSTENNA®. NMS
   can cause death and must be treated in a hospital. Call your healthcare
   professional right away if you become severely ill and have any of these
   symptoms: high fever; severe muscle stiffness; confusion; loss of
   consciousness; changes in your breathing, heartbeat, and blood pressure.
 * problems with your heartbeat. These heart problems can cause death. Call your
   healthcare professional right away if you have any of these symptoms: passing
   out or feeling like you will pass out, dizziness, or feeling as if your heart
   is pounding or missing beats.
 * uncontrolled movements of your tongue, face, mouth, or jaw (tardive
   dyskinesia)
 * metabolic changes. Metabolic changes may include high blood sugar
   (hyperglycemia), diabetes mellitus and changes in the fat levels in your
   blood (dyslipidemia), and weight gain.
 * low blood pressure and fainting
 * changes in your blood cell counts
 * high level of prolactin in your blood (hyperprolactinemia). INVEGA
   TRINZA® or INVEGA SUSTENNA® may cause a rise in the blood levels of a hormone
   called prolactin (hyperprolactinemia) that may cause side effects including
   missed menstrual periods, leakage of milk from the breasts, development of
   breasts in men, or problems with erection.
 * problems thinking clearly and moving your body
 * seizures
 * difficulty swallowing that can cause food or liquid to get into your lungs
 * prolonged or painful erection lasting more than 4 hours. Call your healthcare
   professional or go to your nearest emergency room right away if you have an
   erection that lasts more than 4 hours.
 * problems with control of your body temperature, especially when you exercise
   a lot or spend time doing things that make you warm. It is important for you
   to drink water to avoid dehydration.

The most common side effects of INVEGA TRINZA®  include: injection site
reactions, weight gain, headache, upper respiratory tract infections, feeling
restlessness or difficulty sitting still, slow movements, tremors, stiffness and
shuffling walk.

The most common side effects of INVEGA SUSTENNA® include: injection site
reactions; sleepiness or drowsiness; dizziness; feeling of inner restlessness or
needing to be constantly moving; abnormal muscle movements, including tremor
(shaking), shuffling, uncontrolled involuntary movements, and abnormal movements
of your eyes.

Tell your healthcare professional if you have any side effect that bothers you
or does not go away. These are not all the possible side effects of INVEGA
TRINZA® or INVEGA SUSTENNA®. For more information, ask your healthcare
professional or pharmacist.

Call your healthcare professional for medical advice about side effects. You may
report side effects of prescription drugs to the FDA at 1‑800‑FDA‑1088.

General information about the safe and effective use of INVEGA TRINZA® or INVEGA
SUSTENNA®

Medicines are sometimes prescribed for purposes other than those listed in a
Patient Information leaflet. Do not use INVEGA TRINZA® or INVEGA SUSTENNA® for a
condition for which it was not prescribed. Do not give INVEGA TRINZA® or INVEGA
SUSTENNA® to other people, even if they have the same symptoms that you have. It
may harm them. You can ask your pharmacist or healthcare professional for
information about INVEGA TRINZA® or INVEGA SUSTENNA® that is written for
healthcare professionals.

This Patient Information leaflet summarizes the most important information about
INVEGA TRINZA® and INVEGA SUSTENNA®. If you would like more information, talk
with your healthcare professional.

You can ask your healthcare professional or pharmacist for more information that
is written for healthcare professionals. For more information, go to
www.invegatrinza.com or www.invegasustenna.com or call 1‑800‑526‑7736.

Please click to read the full Prescribing Information, including Boxed WARNING,
for INVEGA TRINZA® and INVEGA SUSTENNA® and discuss any questions you have with
your healthcare professional.

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INDICATIONS

INDICATIONS

INVEGA TRINZA® (3-month paliperidone palmitate) is a prescription medicine given
by injection every 3 months by a healthcare professional and used to treat
schizophrenia. INVEGA TRINZA® is used in people who have been treated with
INVEGA SUSTENNA® (1-month paliperidone palmitate) for at least 4 months.

INVEGA SUSTENNA® (In-VEY-guh Suss-TEN-uh) (paliperidone palmitate) is a
prescription medicine given by injection by a healthcare professional. INVEGA
SUSTENNA® is used to treat schizophrenia in adults.




IMPORTANT SAFETY INFORMATION

What is the most important information I should know about INVEGA TRINZA® and
INVEGA SUSTENNA®?

INVEGA TRINZA® and INVEGA SUSTENNA® can cause serious side effects, including an
increased risk of death in elderly people who are confused, have memory loss,
and have lost touch with reality (dementia-related psychosis). INVEGA TRINZA®
and INVEGA SUSTENNA® are not for treating dementia-related psychosis.

Do not receive INVEGA TRINZA® or INVEGA SUSTENNA® if you are allergic to
paliperidone, paliperidone palmitate, risperidone, or any of the ingredients in
INVEGA TRINZA® or INVEGA SUSTENNA®. See the end of the Patient Information
leaflet in the full Prescribing Information for a complete list of INVEGA
TRINZA® and INVEGA SUSTENNA® ingredients.

Before you receive INVEGA TRINZA® or INVEGA SUSTENNA®, tell your healthcare
professional about all your medical conditions, including if you:

 * have had Neuroleptic Malignant Syndrome (NMS)
 * have or have had heart problems, including a heart attack, heart failure,
   abnormal heart rhythm, or long QT syndrome
 * have or have had low levels of potassium or magnesium in your blood
 * have or have had uncontrolled movements of your tongue, face, mouth, or jaw
   (tardive dyskinesia)
 * have or have had kidney or liver problems
 * have diabetes or have a family history of diabetes
 * have had a low white blood cell count
 * have had problems with dizziness or fainting or are being treated for high
   blood pressure
 * have or have had seizures or epilepsy
 * have any other medical conditions
 * are pregnant or plan to become pregnant. It is not known if INVEGA TRINZA® or
   INVEGA SUSTENNA® will harm your unborn baby
   * If you become pregnant while taking INVEGA TRINZA® or INVEGA SUSTENNA®,
     talk to your healthcare professional about registering with the National
     Pregnancy Registry for Atypical Antipsychotics. You can register by calling
     1-866-961-2388 or
     visit http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry.
   * Infants born to women who are treated with INVEGA TRINZA® or INVEGA
     SUSTENNA® may experience symptoms such as tremors, irritability, excessive
     sleepiness, eye twitching, muscle spasms, decreased appetite, difficulty
     breathing, or abnormal movement of arms and legs. Let your healthcare
     professional know if these symptoms occur.
 * are breastfeeding or plan to breastfeed. INVEGA TRINZA® or INVEGA SUSTENNA®
   can pass into your breast milk. Talk to your healthcare professional about
   the best way to feed your baby if you receive INVEGA TRINZA® or INVEGA
   SUSTENNA®.

Tell your healthcare professional about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.
Know the medicines you take. Keep a list of them to show to your healthcare
professional or pharmacist when you get a new medicine.

Patients (particularly the elderly) taking antipsychotics with certain health
conditions or those on long-term therapy should be evaluated by their healthcare
professional for the potential risk of falls.

What should I avoid while receiving INVEGA TRINZA® or INVEGA SUSTENNA®?

 * INVEGA TRINZA® and INVEGA SUSTENNA® may affect your ability to make
   decisions, think clearly, or react quickly. Do not drive, operate heavy
   machinery, or do other dangerous activities until you know how INVEGA
   TRINZA® or INVEGA SUSTENNA® affects you.
 * Avoid getting overheated or dehydrated.

INVEGA TRINZA® and INVEGA SUSTENNA® may cause serious side effects, including:

 * See “What is the most important information I should know about INVEGA
   TRINZA® and INVEGA SUSTENNA®?”
 * stroke in elderly people (cerebrovascular problems) that can lead to death
 * Neuroleptic Malignant Syndrome (NMS). NMS is a rare but very serious problem
   that can happen in people who receive INVEGA TRINZA® or INVEGA SUSTENNA®. NMS
   can cause death and must be treated in a hospital. Call your healthcare
   professional right away if you become severely ill and have any of these
   symptoms: high fever; severe muscle stiffness; confusion; loss of
   consciousness; changes in your breathing, heartbeat, and blood pressure.
 * problems with your heartbeat. These heart problems can cause death. Call your
   healthcare professional right away if you have any of these symptoms: passing
   out or feeling like you will pass out, dizziness, or feeling as if your heart
   is pounding or missing beats.
 * uncontrolled movements of your tongue, face, mouth, or jaw (tardive
   dyskinesia)
 * metabolic changes. Metabolic changes may include high blood sugar
   (hyperglycemia), diabetes mellitus and changes in the fat levels in your
   blood (dyslipidemia), and weight gain.
 * low blood pressure and fainting
 * changes in your blood cell counts
 * high level of prolactin in your blood (hyperprolactinemia). INVEGA
   TRINZA® or INVEGA SUSTENNA® may cause a rise in the blood levels of a hormone
   called prolactin (hyperprolactinemia) that may cause side effects including
   missed menstrual periods, leakage of milk from the breasts, development of
   breasts in men, or problems with erection.
 * problems thinking clearly and moving your body
 * seizures
 * difficulty swallowing that can cause food or liquid to get into your lungs
 * prolonged or painful erection lasting more than 4 hours. Call your healthcare
   professional or go to your nearest emergency room right away if you have an
   erection that lasts more than 4 hours.
 * problems with control of your body temperature, especially when you exercise
   a lot or spend time doing things that make you warm. It is important for you
   to drink water to avoid dehydration.

The most common side effects of INVEGA TRINZA®  include: injection site
reactions, weight gain, headache, upper respiratory tract infections, feeling
restlessness or difficulty sitting still, slow movements, tremors, stiffness and
shuffling walk.

The most common side effects of INVEGA SUSTENNA® include: injection site
reactions; sleepiness or drowsiness; dizziness; feeling of inner restlessness or
needing to be constantly moving; abnormal muscle movements, including tremor
(shaking), shuffling, uncontrolled involuntary movements, and abnormal movements
of your eyes.

Tell your healthcare professional if you have any side effect that bothers you
or does not go away. These are not all the possible side effects of INVEGA
TRINZA® or INVEGA SUSTENNA®. For more information, ask your healthcare
professional or pharmacist.

Call your healthcare professional for medical advice about side effects. You may
report side effects of prescription drugs to the FDA at 1‑800‑FDA‑1088.

General information about the safe and effective use of INVEGA TRINZA® or INVEGA
SUSTENNA®

Medicines are sometimes prescribed for purposes other than those listed in a
Patient Information leaflet. Do not use INVEGA TRINZA® or INVEGA SUSTENNA® for a
condition for which it was not prescribed. Do not give INVEGA TRINZA® or INVEGA
SUSTENNA® to other people, even if they have the same symptoms that you have. It
may harm them. You can ask your pharmacist or healthcare professional for
information about INVEGA TRINZA® or INVEGA SUSTENNA® that is written for
healthcare professionals.

This Patient Information leaflet summarizes the most important information about
INVEGA TRINZA® and INVEGA SUSTENNA®. If you would like more information, talk
with your healthcare professional.

You can ask your healthcare professional or pharmacist for more information that
is written for healthcare professionals. For more information, go to
www.invegatrinza.com or www.invegasustenna.com or call 1‑800‑526‑7736.

Please click to read the full Prescribing Information, including Boxed WARNING,
for INVEGA TRINZA® and INVEGA SUSTENNA® and discuss any questions you have with
your healthcare professional.

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