www.chemexpress.cn Open in urlscan Pro
2606:4700:3030::681f:5216  Public Scan

Form analysis
2 forms found in the DOM

Name: searchInfo — GET mce_searchproduct.shtml

<form name="searchInfo" id="searchInfo" class="search-form" method="get" action="mce_searchproduct.shtml">
  <input type="search" class="search-field" name="productParam" id="productParam" placeholder="eg. Name, CAS">
  <input type="button" class="search-submit" onclick="search1();">
</form>

Name: InquiryForm — POST /mce_productDetail.shtml;jsessionid=29266DE4165CC9AEC2C0469B99F55E5C

<form id="commentform" name="InquiryForm" action="/mce_productDetail.shtml;jsessionid=29266DE4165CC9AEC2C0469B99F55E5C" method="post" class="comment-form">
  <input type="hidden" name="catalogNo" size="30" value="HY-107319">
  <input type="hidden" name="iqDetail.productId" size="30" value="ff6c5046-f07e-4b70-9a1a-44c90307ab81">
  <input type="hidden" name="iqDetail.productName" id="iqDetail_productName" size="30" value="Almitrine mesylate">
  <input type="hidden" name="iqDetail.casNo" id="iqDetail.casNo" size="30" value="29608-49-9">
  <div class="row">
    <div class="col-lg-6">
      <label class="col-sm-2 control-label Important">Salutation: </label>
      <div class="col-sm-10">
        <select name="cmInqriry.salutation" id="cmInqriry.salutation" class="form-control input-lg Required">
          <option value="9003001">Dr.</option>
          <option value="9003003">Prof.</option>
          <option value="9003005">Mr.</option>
          <option value="9003007">Ms.</option>
          <option value="9003009">Mrs.</option>
          <option value="9003011">Miss.</option>
        </select>
      </div>
    </div>
    <div class="col-lg-6">
      <label class="col-sm-3 control-label Importants" style="font-weight: normal;font-size: 14px;padding: 0">Country: </label>
      <div class="col-sm-9">
        <select name="cmInqriry.countryId" id="cmInqriry.countryId" class="form-control input-lg Required">
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          <option value=""></option>
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 * 29608-49-9


ALMITRINE MESYLATE


CAS No. : 29608-49-9

(Synonyms: Almitrine bismesylate; Almitrine bismethanesulfonate; Almitrine
dimesylate)

Price and Availability of CAS No. : 29608-49-9

Size Price Stock 10mg $60 In-stock 50mg $120 In-stock 100mg $190 In-stock 200 mg
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Cat. No. : HY-107319 M.Wt: 669.76 Formula: C28H37F2N7O6S2 Purity: >98 % Storage:
at 20℃ 2 years Solubility: DMSO : 125 mg/mL (186.63 mM; Need ultrasonic)

Introduction of 29608-49-9 :

Almitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the
Ca2+-dependent K+ channel. IC50 & Target: K+ channel[1] In Vitro: Almitrine
inhibits the activity of a high-conductance (152±13 pS), Ca2+-dependent K+
channel by decreasing its open probability. The IC50 value of the effect is 0.22
μM. The inhibitory effect of Almitrine on Ca2+-dependent K+ channels also is
observed in GH3 cells. Almitrine at concentrations up to 10 μM does not affect
whole-cell voltage-dependent K+, Ca2+, or Na+ currents in rat or rabbit cells.
However, this concentration of Almitrine significantly inhibits the
Ca2+-dependent component of K+ currents in rat chemoreceptor cells[1]. In Vivo:
Almitrine acts via the peripheral arterial chemoreceptors raising carotid sinus
nerve output and minute ventilation. Almitrine also has a pulmonary vascular
action causing a dose-dependent constriction and dilatation. At low doses
Almitrine enhances hypoxic pulmonary vasoconstriction and may improve the
overall ventilation/perfusion ratio[2].


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