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Submitted URL: https://5dfu7dhbb.cc.rs6.net/tn.jsp?f=001mYtwGFFf1bH4LcVvofG7ycJTH-CUBeu1hfHc2ZAWm-fiyozFaZQafrTBNTOf88bxPiGhuoGAIaeoBRQ1BlOj...
Effective URL: https://finance.yahoo.com/news/maia-biotechnology-announces-positive-survival-100000548.html
Submission: On December 17 via api from BE — Scanned from PT
Effective URL: https://finance.yahoo.com/news/maia-biotechnology-announces-positive-survival-100000548.html
Submission: On December 17 via api from BE — Scanned from PT
Form analysis 2 forms found in the DOM
Name: ybar_mod_searchbox_s — GET https://finance.yahoo.com/lookup/
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<div class="finsrch-rslt finsrch-custom-rst finsrch-show-recomlst finsrch-show-ftr hidden modules-module_greenSrchRslt__Iemde modules-module_noDisplay__0NU79">
<div class="modules-module_resultsWrapper__YGfQD">
<div class="modules-module_resultsContainerRedesign__yG1rH" data-id="search-assist-input-sugglst"></div>
<footer data-id="search-assist-footer" class="modules-module_noDisplay__0NU79">
<p class="modules-module_tipMessage__ZQFev">Tip: Try a valid symbol or a specific company name for relevant results</p>
</footer>
</div>
<div data-id="search-assist-input-recomlst">
<div class="modules-module_sectionHeaderNoBrdr__j5DP2 ">
<h3 class="modules-module_sectionHeaderTitleLight__NrKIv">Trending Tickers</h3>
</div>
<ul role="listbox" class="modules-module_recPillList__VH0mw">
<li role="option" title="TSLA" tabindex="0" data-type="recommend" data-id="result-recommend-0" data-test="srch-trd-sym" data-index="0" data-pindex="0" class="modules-module_recLinkItem__eEOpb modules-module_selectedBackground__6dnU7">
<div class="modules-module_recPillContainer__jDQx1">
<div class="modules-module_recPillDefaultLogo__QoEuV"><img loading="lazy" src="https://s.yimg.com/lb/brands/150x150_tesla.png" alt="TSLA-logo" class="modules-module_recPillLogo__lI83F"></div><span
class="modules-module_recPillSymbol__mxoJP">TSLA</span>
<div class="modules-module_recPriceContainer__fM8pf"><fin-streamer data-symbol="TSLA" data-field="regularMarketPrice" data-trend="none" data-pricehint="2" value="463.02" active="">
<span>463.02</span>
</fin-streamer></div>
<div class="modules-module_recPercentContainer__0wUk2 modules-module_positive__gnzPV percentChangeWrapper">(<fin-streamer class="percentChange modules-module_arrows__x4-uX" data-symbol="TSLA" data-field="regularMarketChangePercent"
data-trend="txt" data-pricehint="2" value="6.1412506" data-tstyle="default" active="">
<span class="modules-module_arrows__x4-uX">+6.14%</span>
</fin-streamer>)</div>
</div>
</li>
<li role="option" title="QUBT" tabindex="0" data-type="recommend" data-id="result-recommend-1" data-test="srch-trd-sym" data-index="1" data-pindex="1" class="modules-module_recLinkItem__eEOpb">
<div class="modules-module_recPillContainer__jDQx1">
<div class="modules-module_recPillDefaultLogo__QoEuV">Q</div><span class="modules-module_recPillSymbol__mxoJP">QUBT</span>
<div class="modules-module_recPriceContainer__fM8pf"><fin-streamer data-symbol="QUBT" data-field="regularMarketPrice" data-trend="none" data-pricehint="2" value="11.08" active="">
<span>11.08</span>
</fin-streamer></div>
<div class="modules-module_recPercentContainer__0wUk2 modules-module_positive__gnzPV percentChangeWrapper">(<fin-streamer class="percentChange modules-module_arrows__x4-uX" data-symbol="QUBT" data-field="regularMarketChangePercent"
data-trend="txt" data-pricehint="2" value="65.24981" data-tstyle="default" active="">
<span class="modules-module_arrows__x4-uX">+65.25%</span>
</fin-streamer>)</div>
</div>
</li>
<li role="option" title="SIDU" tabindex="0" data-type="recommend" data-id="result-recommend-2" data-test="srch-trd-sym" data-index="2" data-pindex="2" class="modules-module_recLinkItem__eEOpb">
<div class="modules-module_recPillContainer__jDQx1">
<div class="modules-module_recPillDefaultLogo__QoEuV">S</div><span class="modules-module_recPillSymbol__mxoJP">SIDU</span>
<div class="modules-module_recPriceContainer__fM8pf"><fin-streamer data-symbol="SIDU" data-field="regularMarketPrice" data-trend="none" data-pricehint="4" value="4.58" active="">
<span>4.5800</span>
</fin-streamer></div>
<div class="modules-module_recPercentContainer__0wUk2 modules-module_positive__gnzPV percentChangeWrapper">(<fin-streamer class="percentChange modules-module_arrows__x4-uX" data-symbol="SIDU" data-field="regularMarketChangePercent"
data-trend="txt" data-pricehint="4" value="220.27974" data-tstyle="default" active="">
<span class="modules-module_arrows__x4-uX">+220.28%</span>
</fin-streamer>)</div>
</div>
</li>
<li role="option" title="NVDA" tabindex="0" data-type="recommend" data-id="result-recommend-3" data-test="srch-trd-sym" data-index="3" data-pindex="3" class="modules-module_recLinkItem__eEOpb">
<div class="modules-module_recPillContainer__jDQx1">
<div class="modules-module_recPillDefaultLogo__QoEuV"><img loading="lazy" src="https://s.yimg.com/lb/brands/150x150_nvidia.png" alt="NVDA-logo" class="modules-module_recPillLogo__lI83F"></div><span
class="modules-module_recPillSymbol__mxoJP">NVDA</span>
<div class="modules-module_recPriceContainer__fM8pf"><fin-streamer data-symbol="NVDA" data-field="regularMarketPrice" data-trend="none" data-pricehint="2" value="132" active="">
<span>132.00</span>
</fin-streamer></div>
<div class="modules-module_recPercentContainer__0wUk2 modules-module_negative__zlMEC percentChangeWrapper">(<fin-streamer class="percentChange modules-module_arrows__x4-uX" data-symbol="NVDA" data-field="regularMarketChangePercent"
data-trend="txt" data-pricehint="2" value="-1.6759777" data-tstyle="default" active="">
<span class="modules-module_arrows__x4-uX">-1.68%</span>
</fin-streamer>)</div>
</div>
</li>
<li role="option" title="GME" tabindex="0" data-type="recommend" data-id="result-recommend-4" data-test="srch-trd-sym" data-index="4" data-pindex="4" class="modules-module_recLinkItem__eEOpb">
<div class="modules-module_recPillContainer__jDQx1">
<div class="modules-module_recPillDefaultLogo__QoEuV"><img loading="lazy" src="https://s.yimg.com/lb/brands/150x150_gamestop.png" alt="GME-logo" class="modules-module_recPillLogo__lI83F"></div><span
class="modules-module_recPillSymbol__mxoJP">GME</span>
<div class="modules-module_recPriceContainer__fM8pf"><fin-streamer data-symbol="GME" data-field="regularMarketPrice" data-trend="none" data-pricehint="2" value="29.44" active="">
<span>29.44</span>
</fin-streamer></div>
<div class="modules-module_recPercentContainer__0wUk2 modules-module_positive__gnzPV percentChangeWrapper">(<fin-streamer class="percentChange modules-module_arrows__x4-uX" data-symbol="GME" data-field="regularMarketChangePercent"
data-trend="txt" data-pricehint="2" value="5.18042" data-tstyle="default" active="">
<span class="modules-module_arrows__x4-uX">+5.18%</span>
</fin-streamer>)</div>
</div>
</li>
</ul>
</div>
</div>
</form><form data-finsrch="quote" role="search" class="dock-srch yf-cs8l6v" fininit="">
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<path
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<div class="finsrch-rslt finsrch-custom-rst finsrch-show-recomlst yf-cs8l6v finsrch-show-ftr modules-module_noDisplay__0NU79">
<div class="modules-module_resultsWrapper__YGfQD">
<div class="modules-module_resultsContainerRedesign__yG1rH" data-id="search-assist-input-sugglst"></div>
<footer data-id="search-assist-footer" class="modules-module_noDisplay__0NU79">
<p class="modules-module_tipMessage__ZQFev">Tip: Try a valid symbol or a specific company name for relevant results</p>
</footer>
</div>
<div data-id="search-assist-input-recomlst">
<div class="modules-module_sectionHeaderNoBrdr__j5DP2 ">
<h3 class="modules-module_sectionHeaderTitleLight__NrKIv">Trending Tickers</h3>
</div>
<ul role="listbox" class="modules-module_list__hi5kT">
<li role="option" title="Tesla, Inc." tabindex="0" data-type="recommend" data-id="result-recommend-0" data-test="srch-trd-sym" data-index="0" data-pindex="0"
class="modules-module_linkItemLgNeoGreenLg__X88Wg modules-module_quoteItem__W8hI- modules-module_selectedBackground__6dnU7">
<div class="modules-module_quoteLeftCol__yV9LA modules-module_Ell__N1WPm modules-module_IbBox__NPYId">
<div class="modules-module_quoteCompanyInfo__ULJ7V modules-module_Ell__N1WPm">
<div class="modules-module_quoteSymbol__BGsyF">TSLA</div>
<div class="modules-module_quoteCompanyName__JVZCM modules-module_Ell__N1WPm">Tesla, Inc.</div>
</div>
</div>
<div class="modules-module_quoteRightCol__iH6f-">
<div class="undefined"><span>Equity</span><span class="modules-module_quoteTypeExchange__omxiA">NMS</span></div>
</div>
</li>
<li role="option" title="Quantum Computing Inc." tabindex="0" data-type="recommend" data-id="result-recommend-1" data-test="srch-trd-sym" data-index="1" data-pindex="1"
class="modules-module_linkItemLgNeoGreenLg__X88Wg modules-module_quoteItem__W8hI- ">
<div class="modules-module_quoteLeftCol__yV9LA modules-module_Ell__N1WPm modules-module_IbBox__NPYId">
<div class="modules-module_quoteCompanyInfo__ULJ7V modules-module_Ell__N1WPm">
<div class="modules-module_quoteSymbol__BGsyF">QUBT</div>
<div class="modules-module_quoteCompanyName__JVZCM modules-module_Ell__N1WPm">Quantum Computing Inc.</div>
</div>
</div>
<div class="modules-module_quoteRightCol__iH6f-">
<div class="undefined"><span>Equity</span><span class="modules-module_quoteTypeExchange__omxiA">NCM</span></div>
</div>
</li>
<li role="option" title="Sidus Space, Inc." tabindex="0" data-type="recommend" data-id="result-recommend-2" data-test="srch-trd-sym" data-index="2" data-pindex="2"
class="modules-module_linkItemLgNeoGreenLg__X88Wg modules-module_quoteItem__W8hI- ">
<div class="modules-module_quoteLeftCol__yV9LA modules-module_Ell__N1WPm modules-module_IbBox__NPYId">
<div class="modules-module_quoteCompanyInfo__ULJ7V modules-module_Ell__N1WPm">
<div class="modules-module_quoteSymbol__BGsyF">SIDU</div>
<div class="modules-module_quoteCompanyName__JVZCM modules-module_Ell__N1WPm">Sidus Space, Inc.</div>
</div>
</div>
<div class="modules-module_quoteRightCol__iH6f-">
<div class="undefined"><span>Equity</span><span class="modules-module_quoteTypeExchange__omxiA">NCM</span></div>
</div>
</li>
<li role="option" title="NVIDIA Corporation" tabindex="0" data-type="recommend" data-id="result-recommend-3" data-test="srch-trd-sym" data-index="3" data-pindex="3"
class="modules-module_linkItemLgNeoGreenLg__X88Wg modules-module_quoteItem__W8hI- ">
<div class="modules-module_quoteLeftCol__yV9LA modules-module_Ell__N1WPm modules-module_IbBox__NPYId">
<div class="modules-module_quoteCompanyInfo__ULJ7V modules-module_Ell__N1WPm">
<div class="modules-module_quoteSymbol__BGsyF">NVDA</div>
<div class="modules-module_quoteCompanyName__JVZCM modules-module_Ell__N1WPm">NVIDIA Corporation</div>
</div>
</div>
<div class="modules-module_quoteRightCol__iH6f-">
<div class="undefined"><span>Equity</span><span class="modules-module_quoteTypeExchange__omxiA">NMS</span></div>
</div>
</li>
<li role="option" title="GameStop Corp." tabindex="0" data-type="recommend" data-id="result-recommend-4" data-test="srch-trd-sym" data-index="4" data-pindex="4"
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MAIA Biotechnology Announces Positive Survival Updates in Phase 2 Study of THIO
in Non-Small Cell Lung Cancer
Business Wire
September 10, 2024 6 min read
IN THIS ARTICLE:
MAIA
+10.00%
* 16 patients surpassed 12-month survival follow-up
* THIO's substantial survival benefit in third line surpasses comparable
standard-of-care overall survival of 5.8 months
* Median survival follow-up in third line was 10.6 months
* Treatment with THIO followed by Libtayo® has been generally well-tolerated to
date
CHICAGO, September 10, 2024--(BUSINESS WIRE)--MAIA Biotechnology, Inc., (NYSE
American: MAIA) ("MAIA", the "Company"), a clinical-stage biopharmaceutical
company developing targeted immunotherapies for cancer, today announces
favorable interim survival benefit from its lead clinical candidate THIO, a
telomere-targeting treatment for patients with advanced non-small cell lung
cancer (NSCLC). A Phase 2 clinical trial, THIO-101, is evaluating THIO sequenced
with Regeneron’s immune checkpoint inhibitor (CPI) cemiplimab (Libtayo®) in
patients with advanced NSCLC who failed two or more standard-of-care therapy
regimens.
Published available results suggest that overall survival (OS) in third-line
patients is 5.8 months.1
As of August 01, 2024, 16 patients had survival follow-up surpassing 12 months,
including 9 in third line treatment (3L). Interim median survival follow-up in
3L was 10.6 months.
"THIO is showing a survival benefit for patients with advanced NSCLC. As our
follow-up continues, we have noted that three of the earliest patients enrolled
are approaching 17-month survival. We’re on track to achieve our survival goals
in third-line therapy," said Vlad Vitoc, M.D., Chairman and Chief Executive
Officer of MAIA. "THIO’s outperformance to date supports our thesis that our
telomere targeting agent could become a treatment option for people suffering
from advanced NSCLC."
The 12-month survival data corresponds to the Company’s most recent data from
THIO-101 demonstrating favorable disease control and overall response rates. As
announced in April 2024, THIO 180mg + CPI in third-line treatment showed, in
part, overall response rate (ORR) of 38%, disease control rate (DCR) of 88% and
median progression-free survival (PFS) of 5.5 months.
MAIA expects to release full efficacy results of THIO-101 this year.
About THIO
THIO (6-thio-dG or 6-thio-2’-deoxyguanosine) is a first-in-class investigational
telomere-targeting agent currently in clinical development to evaluate its
activity in Non-Small Cell Lung Cancer (NSCLC). Telomeres, along with the enzyme
telomerase, play a fundamental role in the survival of cancer cells and their
resistance to current therapies. The modified nucleotide
6-thio-2’-deoxyguanosine (THIO) induces telomerase-dependent telomeric DNA
modification, DNA damage responses, and selective cancer cell death.
THIO-damaged telomeric fragments accumulate in cytosolic micronuclei and
activates both innate (cGAS/STING) and adaptive (T-cell) immune responses. The
sequential treatment with THIO followed by PD-(L)1 inhibitors resulted in
profound and persistent tumor regression in advanced, in vivo cancer models by
induction of cancer type–specific immune memory. THIO is presently developed as
a second or later line of treatment for NSCLC for patients that have progressed
beyond the standard-of-care regimen of existing checkpoint inhibitors.
Story Continues
About THIO-101, a Phase 2 Clinical Trial
THIO-101 is a multicenter, open-label, dose finding Phase 2 clinical trial. It
is the first trial designed to evaluate THIO’s anti-tumor activity when followed
by PD-(L)1 inhibition. The trial is testing the hypothesis that low doses of
THIO administered prior to cemiplimab (Libtayo®) will enhance and prolong immune
response in patients with advanced NSCLC who previously did not respond or
developed resistance and progressed after first-line treatment regimen
containing another checkpoint inhibitor. The trial design has two primary
objectives: (1) to evaluate the safety and tolerability of THIO administered as
an anticancer compound and a priming immune activator (2) to assess the clinical
efficacy of THIO using Overall Response Rate (ORR) as the primary clinical
endpoint. Treatment with THIO followed by Regeneron’s cemiplimab (Libtayo®) has
been generally well-tolerated to date in a heavily pre-treated population. For
more information on this Phase II trial, please visit ClinicalTrials.gov using
the identifier NCT05208944.
About MAIA Biotechnology, Inc.
MAIA is a targeted therapy, immuno-oncology company focused on the development
and commercialization of potential first-in-class drugs with novel mechanisms of
action that are intended to meaningfully improve and extend the lives of people
with cancer. Our lead program is THIO, a potential first-in-class cancer
telomere targeting agent in clinical development for the treatment of NSCLC
patients with telomerase-positive cancer cells. For more information, please
visit www.maiabiotech.com.
Forward Looking Statements
MAIA cautions that all statements, other than statements of historical facts
contained in this press release, are forward-looking statements. Forward-looking
statements are subject to known and unknown risks, uncertainties, and other
factors that may cause our or our industry’s actual results, levels or activity,
performance or achievements to be materially different from those anticipated by
such statements. The use of words such as "may," "might," "will," "should,"
"could," "expect," "plan," "anticipate," "believe," "estimate," "project,"
"intend," "future," "potential," or "continue," and other similar expressions
are intended to identify forward looking statements. However, the absence of
these words does not mean that statements are not forward-looking. For example,
all statements we make regarding (i) the initiation, timing, cost, progress and
results of our preclinical and clinical studies and our research and development
programs, (ii) our ability to advance product candidates into, and successfully
complete, clinical studies, (iii) the timing or likelihood of regulatory filings
and approvals, (iv) our ability to develop, manufacture and commercialize our
product candidates and to improve the manufacturing process, (v) the rate and
degree of market acceptance of our product candidates, (vi) the size and growth
potential of the markets for our product candidates and our ability to serve
those markets, and (vii) our expectations regarding our ability to obtain and
maintain intellectual property protection for our product candidates, are
forward looking. All forward-looking statements are based on current estimates,
assumptions and expectations by our management that, although we believe to be
reasonable, are inherently uncertain. Any forward-looking statement expressing
an expectation or belief as to future events is expressed in good faith and
believed to be reasonable at the time such forward-looking statement is made.
However, these statements are not guarantees of future events and are subject to
risks and uncertainties and other factors beyond our control that may cause
actual results to differ materially from those expressed in any forward-looking
statement. Any forward-looking statement speaks only as of the date on which it
was made. We undertake no obligation to publicly update or revise any
forward-looking statement, whether as a result of new information, future events
or otherwise, except as required by law. In this release, unless the context
requires otherwise, "MAIA," "Company," "we," "our," and "us" refers to MAIA
Biotechnology, Inc. and its subsidiaries.
1 Girard N, et al. J Thorac Onc 2009;12:1544-1549.
View source version on businesswire.com:
https://www.businesswire.com/news/home/20240910368128/en/
Contacts
Investor Relations Contact
+1 (872) 270-3518
ir@maiabiotech.com
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